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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prnp
prion protein
MGI:97769
117 phenotypes from 41 alleles in 24 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Not Specified 		normal behavior/neurological phenotype J:89232
normal immune system phenotype J:89232
male infertility J:89232
normal nervous system phenotype J:89232
teratozoospermia J:89232
Prnp/Prndtm1Dwm/Prnp/Prndtm1Dwm
129P2/OlaHsd-Prnp/Prndtm1Dwm 		impaired acrosome reaction J:91094
impaired fertilization J:91094
male infertility J:91094
Prnpa/Prnpa
NZW 		increased susceptibility to prion infection J:8918
Prnpb/Prnpb
I/LnJ 		decreased susceptibility to prion infection J:8918
Prnpc/Prnpc
MAI/Pas 		decreased susceptibility to prion infection J:90099
Prnptm1Canc/Prnptm1Canc
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:105909
Prnptm1Cwe/Prnptm1Cwe
involves: 129S7/SvEvBrd * C57BL/6 		abnormal CNS synaptic transmission J:19448
abnormal inhibitory postsynaptic currents J:19448
abnormal inhibitory postsynaptic potential J:19448
normal behavior/neurological phenotype J:472, J:67593
decreased brain copper level J:126728
reduced long-term potentiation J:19448
Prnptm1Cwe/Prnptm1Cwe
Tg(Lck-Prnp)33Cwe/0
involves: 129S7/SvEvBrd * C57BL/6 		increased CD8-positive, alpha-beta T cell number J:129512
increased gamma-delta T cell number J:129512
thymus hypoplasia J:129512
Prnptm1Cwe/Prnptm1Cwe
Tg(Nefh-cre)22Jcol/Tg(Nefh-cre)22Jcol
Tg(Prnp)46Jcol/Tg(Prnp)46Jcol
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB 		normal nervous system phenotype J:74652
Prnptm1Cwe/Prnptm1Cwe
Tg(Nefh-cre)22Jcol/?
Tg(Prnp)37Jcol/?
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal behavior J:126424
abnormal excitatory postsynaptic potential J:126424
abnormal response to novel object J:126424
decreased locomotor activity J:126424
decreased susceptibility to prion infection J:126424
spongiform encephalopathy J:126424
Prnptm1Cwe/Prnptm1Cwe
Tg(Nefh-cre)22Jcol/?
Tg(Prnp)46Jcol/?
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal afterhyperpolarization J:74652
normal behavior/neurological phenotype J:74652
decreased susceptibility to prion infection J:74652
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)37Jcol/?
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal behavior J:126424
abnormal excitatory postsynaptic potential J:126424
abnormal object recognition memory J:126424
abnormal response to novel object J:126424
decreased grooming behavior J:126424
hyperactivity J:126424
increased susceptibility to induced morbidity/mortality J:74652
increased susceptibility to prion infection J:74652, J:126424
normal nervous system phenotype J:74652
spongiform encephalopathy J:126424
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)46Jcol/?
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB 		normal immune system phenotype J:74652
normal nervous system phenotype J:74652
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)4053Sbp/0
involves: 129S7/SvEvBrd * FVB/N 		increased susceptibility to prion infection J:136434
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a19Cwe/0
Not Specified 		increased susceptibility to prion infection J:32214
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a20Cwe/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal B cell morphology J:129512
abnormal copper level J:129512
abnormal magnesium ion homeostasis J:126728
abnormal T cell differentiation J:129512
decreased CD4-positive, alpha-beta T cell number J:129512
decreased CD8-positive, alpha-beta T cell number J:129512
decreased DN2 thymocyte number J:129512
decreased DN4 thymocyte number J:129512
decreased double-positive T cell number J:129512
decreased thymocyte number J:129512
increased brain copper level J:126728
increased DN3 thymocyte number J:129512
increased double-negative T cell number J:129512
increased gamma-delta T cell number J:129512
thymus atrophy J:129512
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a20Cwe/0
Not Specified 		increased susceptibility to prion infection J:32214
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)C4Cwe/0
involves: 129S7/SvEvBrd * C57BL/6 		decreased brain copper level J:126728
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)c35Cwe/0
Not Specified 		hindlimb paralysis J:32214
increased susceptibility to prion infection J:32214
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*)#Rgab/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		abnormal tail morphology J:183170
astrocytosis J:183170
hindlimb paralysis J:183170
kyphosis J:183170
limb grasping J:183170
muscular atrophy J:183170
myoclonus J:183170
neuron degeneration J:183170
paraparesis J:183170
premature death J:183170
tremors J:183170
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*A116V*M128V)1309Jama/0
involves: 129S7/SvEvBrd 		abnormal gait J:151934
amyloid beta deposits J:151934
ataxia J:151934
brain vacuoles J:151934
impaired righting response J:151934
premature death J:151934
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*D177N*M128V)A21Rchi/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		ataxia J:142098
impaired balance J:142098
kyphosis J:142098
limb grasping J:142098
premature death J:142098
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		ataxia J:142098
impaired balance J:142098
kyphosis J:142098
limb grasping J:142098
premature death J:142098
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*P101L)2866Sbp/0
involves: 129S7/SvEvBrd * FVB/N 		abnormal brain morphology J:136434
abnormal nervous system physiology J:136434
astrocytosis J:136434
premature death J:136434
spongiform encephalopathy J:136434
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*P101L)2866Sbp/Tg(Prnp*P101L)2866Sbp
involves: 129S7/SvEvBrd * FVB/N 		abnormal nervous system physiology J:136434
spongiform encephalopathy J:136434
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal brain morphology J:143528
abnormal cingulum morphology J:143528
abnormal corpus callosum morphology J:143528
abnormal hippocampus stratum lacunosum morphology J:143528
abnormal muscle fiber morphology J:143528
abnormal sciatic nerve morphology J:143528
astrocytosis J:143528
ataxia J:143528
circling J:143528
decreased susceptibility to prion infection J:143528
increased pruritus J:143528
kyphosis J:143528
lethargy J:143528
microgliosis J:143528
muscle degeneration J:143528
paresis J:143528
spongiform encephalopathy J:143528
weight loss J:143528
Prnptm1Cwe/Prnptm2.1Cwe
involves: 129P2/OlaHsd 		abnormal cerebellum morphology J:67593
decreased Purkinje cell number J:67593
tremors J:67593
Prnptm1Edin/Prnptm1Edin
129P2/OlaHsd-Prnptm1Edin/EdinH 		abnormal susceptibility to prion infection J:58820
Prnptm1Ito/Prnptm1Ito
involves: C57BL/6J 		ataxia J:92537
tremors J:92537
Prnptm1Lnq/Prnptm1Lnq
involves: 129P2/OlaHsd * C57BL/6N 		decreased susceptibility to prion infection J:154937
normal nervous system phenotype J:154937
Prnptm1Miy/Prnptm1Miy
involves: 129S4/SvJae * C57BL/6 		ataxia J:32440
decreased susceptibility to prion infection J:69186
impaired coordination J:32440
Purkinje cell degeneration J:32440
Prnptm1Rcm/Prnptm1Rcm
129P2/OlaHsd-Prnptm1Rcm 		abnormal susceptibility to prion infection J:45908
Prnptm1Tuzi/Prnp+
involves: 129P2/OlaHsd 		decreased susceptibility to prion infection J:92302
Prnptm1Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ 		normal immune system phenotype J:92302
Prnptm1Tuzi/Prnptm2Edin
involves: 129P2/OlaHsd 		decreased susceptibility to prion infection J:92302
Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ 		decreased susceptibility to prion infection J:92302
Prnptm1Wsj/Prnptm1Wsj
involves: 129P2/OlaHsd * C57BL/6N 		normal behavior/neurological phenotype J:215179
Prnptm2.1Cwe/Prnptm2.1Cwe
involves: 129P2/OlaHsd 		abnormal cerebellum morphology J:67593
abnormal muscle physiology J:67593
ataxia J:67593
decreased Purkinje cell number J:67593
thin cerebellar molecular layer J:67593
tremors J:67593
Prnptm2.1Cwe/Prnptm2.1Cwe
Not Specified 		gliosis J:89232
Prnptm2Canc/Prnptm2Canc
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:105909
Prnptm2Cwe/Prnptm2Cwe
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:67593
Prnptm2Edin/Prnptm2Edin
B6.129P2-Prnptm2Edin 		abnormal neuron differentiation J:107170
abnormal neuronal precursor proliferation J:107170
Prnptm2Edin/Prnptm2Edin
Tg(Prnp)a20Cwe/0
B6.Cg-Prnptm2Edin Tg(Prnp)a20Cwe 		abnormal neuronal precursor proliferation J:107170
premature neuronal precursor differentiation J:107170
Prnptm2Lnq/Prnptm2Lnq
involves: 129P2/OlaHsd * C57BL/6N 		abnormal behavior J:154937
abnormal body temperature homeostasis J:154937
abnormal brain white matter morphology J:154937
abnormal cerebral cortex morphology J:154937
abnormal nervous system morphology J:154937
abnormal neuron proliferation J:200974
abnormal sleep duration J:200974
abnormal sleep pattern J:154937
abnormal thalamus morphology J:154937, J:200974
brain vacuoles J:154937
cerebellum atrophy J:154937
decreased locomotor activity J:154937
decreased neuron number J:154937
decreased vertical activity J:154937
enlarged brain ventricles J:154937, J:200974
gliosis J:154937
normal immune system phenotype J:154937
impaired coordination J:200974
increased neuron apoptosis J:200974
neurodegeneration J:154937
neuron degeneration J:154937, J:200974
Prnptm2Rcm/Prnptm2Rcm
Not Specified 		ataxia J:42407
Prnptm2Tuzi/Prnp+
involves: 129P2/OlaHsd 		normal immune system phenotype J:92302
Prnptm2Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ 		decreased susceptibility to prion infection J:92302
Prnptm2Tuzi/Prnptm2Edin
involves: 129P2/OlaHsd 		decreased susceptibility to prion infection J:92302
Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ 		decreased susceptibility to prion infection J:92302
Prnptm3Canc/Prnptm3Canc
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:105909
Prnptm3Lnq/Prnptm3Lnq
involves: 129P2/OlaHsd * C57BL/6N 		abnormal cerebellar molecular layer J:200974
abnormal hippocampus CA1 region morphology J:200974
abnormal hippocampus morphology J:200974
abnormal neuron proliferation J:200974
abnormal olfactory bulb morphology J:200974
abnormal retina morphology J:200974
abnormal voluntary movement J:200974
astrocytosis J:200974
decreased locomotor activity J:200974
impaired coordination J:200974
increased neuron apoptosis J:200974
neuron degeneration J:200974
premature death J:200974
spongiform encephalopathy J:200974
Tg(Prnp)1D4Lnq/0
Not Specified 		abnormal cerebellum morphology J:80582
ataxia J:80582
disheveled coat J:80582
excessive scratching J:80582
gliosis J:80582
neuron degeneration J:80582
weight loss J:80582
Tg(Prnp)1D4Lnq/Tg(Prnp)1D4Lnq
Not Specified 		ataxia J:80582
cerebellum atrophy J:80582
gliosis J:80582
neuron degeneration J:80582
Tg(Prnp)2D1Lnq/0
Not Specified 		abnormal gait J:80582
abnormal nervous system morphology J:80582
abnormal tail movements J:80582
ataxia J:80582
cerebellum atrophy J:80582
gliosis J:80582
neuron degeneration J:80582
postnatal growth retardation J:80582
premature death J:80582
Tg(Prnp)4053Sbp/0
involves: FVB/N 		abnormal nervous system physiology J:136434
increased susceptibility to prion infection J:136434
Tg(Prnp)a20Cwe/0
Not Specified 		axon degeneration J:130657
increased susceptibility to prion infection J:130657, J:143528
Tg(Prnp*)#Rgab/0
involves: C57BL/6 * FVB/N 		abnormal tail morphology J:183170
astrocytosis J:183170
hindlimb paralysis J:183170
kyphosis J:183170
limb grasping J:183170
muscular atrophy J:183170
myoclonus J:183170
neuron degeneration J:183170
paraparesis J:183170
premature death J:183170
tremors J:183170
Tg(Prnp*D177N*M128V)A21Rchi/0
involves: C57BL/6 * CBA 		abnormal brain morphology J:142098
abnormal brain wave pattern J:142098
abnormal cerebellar granule cell morphology J:142098
abnormal sleep pattern J:142098
abnormal spatial working memory J:142098
astrocytosis J:142098
ataxia J:142098
impaired balance J:142098
impaired coordination J:142098
kyphosis J:142098
limb grasping J:142098
premature death J:142098
Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi
involves: C57BL/6 * CBA 		abnormal brain morphology J:142098
astrocytosis J:142098
ataxia J:142098
impaired balance J:142098
kyphosis J:142098
limb grasping J:142098
premature death J:142098
Tg(Prnp*P101L)174Sbp/0
involves: C57BL/6 * SJL 		abnormal nervous system morphology J:127373
astrocytosis J:127373
ataxia J:127373
gliosis J:127373
lethargy J:127373
premature death J:127373
spongiform encephalopathy J:127373
Tg(Prnp*P101L)2247Sbp/0
involves: FVB/N 		abnormal brain morphology J:136434
abnormal nervous system physiology J:136434
astrocytosis J:136434
ataxia J:136434
lethargy J:136434
neurodegeneration J:136434
spongiform encephalopathy J:136434
Tg(Prnp*P101L)2862Sbp/0
involves: FVB/N 		abnormal brain morphology J:136434
abnormal nervous system physiology J:136434
astrocytosis J:136434
ataxia J:136434
lethargy J:136434
spongiform encephalopathy J:136434
Tg(Prnp*P101L)2866Sbp/0
involves: FVB/N 		abnormal brain morphology J:136434
abnormal muscle fiber morphology J:136434
abnormal nervous system physiology J:136434
abnormal sciatic nerve morphology J:136434
abnormal skeletal muscle fiber type ratio J:136434
abnormal skeletal muscle morphology J:136434
abnormal Wallerian degeneration J:136434
astrocytosis J:136434
axon degeneration J:136434
myopathy J:136434
neurodegeneration J:136434
premature death J:136434
skeletal muscle fiber degeneration J:136434
spongiform encephalopathy J:136434
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory