Prnp^tm2Cwe
Targeted Allele Detail

Summary

• Symbol: Prnp^tm2Cwe
• Name: prion protein; targeted mutation 2, Charles Weissmann
• MGI ID: MGI:2682347
• Synonyms: Prnp lox2
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^tm2Cwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67593
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was flanked by single loxP sites in intron 2 and following exon 3. (J:67593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 150 strains or lines available

References

• Original: J:67593 Rossi D, et al., Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J. 2001 Feb 15;20(4):694-702
• All: 1 reference(s)