Rapgef2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
MGI:2659071

43 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous involves: 129P2/OlaHsd * 129S1/Sv	normal hematopoietic system phenotype	J:165879
	normal immune system phenotype	J:165879
Rapgef2^em1(IMPC)H/Rapgef2⁺ C57BL/6N-Rapgef2^em1(IMPC)H/H	abnormal retina morphology	J:211773
	decreased exploration in new environment	J:211773
	increased circulating bilirubin level	J:211773
Rapgef2^em1(IMPC)H/Rapgef2^em1(IMPC)H C57BL/6N-Rapgef2^em1(IMPC)H/H	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous involves: 129S1/Sv	lethality throughout fetal growth and development, incomplete penetrance	J:165879
Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous Tg(CAG-cre/Esr1)5Amc/0 involves: 129S1/Sv C57BL/6 * CBA	abnormal definitive hematopoiesis	J:165879
	abnormal vascular development	J:165879
	decreased birth body size	J:165879
	decreased erythroid progenitor cell number	J:165879
	lethality throughout fetal growth and development, incomplete penetrance	J:165879
	pale liver	J:165879
	pallor	J:165879
Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * C57BL/6 * CBA	normal hematopoietic system phenotype	J:165879
	normal immune system phenotype	J:165879
Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous Tg(Cdh5-cre)7Mlia/0 involves: 129S1/Sv * FVB/N	normal hematopoietic system phenotype	J:165879
	normal immune system phenotype	J:165879
Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * C57BL/6 * CBA	normal hematopoietic system phenotype	J:165879
	normal immune system phenotype	J:165879
Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous Tg(VAV1-cre)1Graf/0 involves: 129S1/Sv	normal hematopoietic system phenotype	J:165879
	normal immune system phenotype	J:165879
Rapgef2^tm1.1Tkat/Rapgef2^tm1.1Tkat involves: 129P2/OlaHsd * C57BL/6	abnormal vascular development	J:125199
	abnormal vasculogenesis	J:125199
	abnormal visceral yolk sac blood island morphology	J:125199
	absent vitelline blood vessels	J:125199
	anencephaly	J:125199
	decreased embryo size	J:125199
	decreased erythrocyte cell number	J:125199
	delayed embryo turning	J:125199
	embryonic growth arrest	J:125199
	embryonic lethality during organogenesis, complete penetrance	J:125199
	enlarged allantois	J:125199
	incomplete embryo turning	J:125199
	pale yolk sac	J:125199
	small placenta	J:125199
	spina bifida	J:125199
	wavy neural tube	J:125199
Rapgef2^tm1.2Hous/Rapgef2^tm1.2Hous involves: 129S1/Sv	abnormal brain development	J:165879
	abnormal cell adhesion	J:165879
	abnormal cell migration	J:165879
	abnormal digestive system development	J:165879
	abnormal embryonic hematopoiesis	J:165879
	abnormal erythropoiesis	J:165879
	abnormal heart development	J:165879
	abnormal hematopoietic stem cell physiology	J:165879
	abnormal liver development	J:165879
	abnormal vascular development	J:165879
	absent erythrocytes	J:165879
	absent vitelline blood vessels	J:165879
	decreased cell proliferation	J:165879
	decreased common myeloid progenitor cell number	J:165879
	decreased embryo size	J:165879
	decreased erythroid progenitor cell number	J:165879
	decreased hematopoietic stem cell number	J:165879
	embryonic lethality during organogenesis, complete penetrance	J:165879
	translucent skin	J:165879

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