84 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ankrd6tm1Pche/Ankrd6tm1Pche Vangl2Lp/Vangl2+ involves: 129 * LPT/LeJ	abnormal cochlear hair cell morphology	J:216288
	abnormal cochlear outer hair cell morphology	J:216288
	female infertility	J:216288
	vagina atresia	J:216288
Bbs1Gt1Nk/Bbs1+ Vangl2Lp/Vangl2+ involves: 129S7/SvEvBrd * LPT/LeJ	abnormal orientation of outer hair cell stereociliary bundles	J:102697
	abnormal outer hair cell stereociliary bundle morphology	J:102697
	embryonic lethality during organogenesis, incomplete penetrance	J:102697
Celsr1Crsh/Celsr1+ Vangl2Lp/Vangl2+ C3H.Cg-Vangl2Lp Celsr1Crsh	abnormal eyelid morphology	J:216413
	abnormal left-right axis patterning	J:216413
	craniorachischisis	J:216413
	omphalocele	J:216413
Celsr1Crsh/Celsr1+ Vangl2Lp/Vangl2+ involves: 101/H * BALB/c * C3H/HeH * CBA * LPT/Le	craniorachischisis	J:216413
	curly tail	J:216413
Celsr1Crsh/Celsr1+ ScribCrc/Scrib+ Vangl2Lp/Vangl2+ C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh	abnormal tail morphology	J:216413
	craniorachischisis	J:216413
	exencephaly	J:216413
Cfl1c5/Cfl1c5 Vangl2Lp/Vangl2Lp involves: C57BL/6J * LPT/LeJ	abnormal direction of heart looping	J:194042
	abnormal embryo turning	J:194042
	abnormal embryonic cilium location or orientation	J:194042
	abnormal heart looping	J:194042
	abnormal left-right axis patterning	J:194042
	abnormal notochord morphology	J:194042
	abnormal primitive node morphology	J:194042
	abnormal somite development	J:194042
	abnormal somite size	J:194042
	decreased embryo size	J:194042
	embryonic growth arrest	J:194042
	embryonic lethality during organogenesis, complete penetrance	J:194042
	failure of heart looping	J:194042
	heterotaxia	J:194042
	open neural tube	J:194042
Cfl1tm1.2Wit/Cfl1tm1.2Wit Vangl2Lp/Vangl2Lp involves: 129 * LPT/LeJ	abnormal embryo turning	J:194042
	abnormal somite development	J:194042
	decreased embryo size	J:194042
	embryonic growth arrest	J:194042
	embryonic lethality during organogenesis, complete penetrance	J:194042
	open neural tube	J:194042
CoblC101/CoblC101 Vangl2Lp/Vangl2+ involves: 129S2/SvPas * LPT/LeJ	exencephaly	J:85744
CoblC101/CoblC101 Vangl2Lp/Vangl2Lp involves: 129S2/SvPas * LPT/LeJ	exencephaly	J:85744
Cthrc1tm1Hssk/Cthrc1+ Vangl2Lp/Vangl2+ involves: 129P2/OlaHsd * C57BL/6	abnormal neural tube closure	J:140886
	normal hearing/vestibular/ear phenotype	J:140886
Cthrc1tm1Hssk/Cthrc1+ Vangl2Lp/Vangl2+ involves: 129P2/OlaHsd * C57BL/6 * CD-1	normal nervous system phenotype	J:140886
Cthrc1tm1Hssk/Cthrc1tm1Hssk Vangl2Lp/Vangl2+ involves: 129P2/OlaHsd * C57BL/6	abnormal cochlear hair cell morphology	J:140886
	abnormal cochlear inner hair cell morphology	J:140886
Dact1tm1.1Bnrc/Dact1+ Vangl2Lp/Vangl2+ B6.Cg-Vangl2Lp Dact1tm1.1Bnrc	curly tail	J:152701
Dact1tm1.1Bnrc/Dact1+ Vangl2Lp-m1Jus/Vangl2+ involves: 101/Rl * 129 * C3H/Rl * C57BL/6	curly tail	J:152701
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc Vangl2Lp-m1Jus/Vangl2+ involves: 101/Rl * 129 * C3H/Rl * C57BL/6	abnormal anus morphology	J:152701
	abnormal digestive system morphology	J:152701
	abnormal external female genitalia morphology	J:152701
	abnormal external male genitalia morphology	J:152701
	abnormal kidney morphology	J:152701
	abnormal urinary bladder morphology	J:152701
	caudal body truncation	J:152701
	curly tail	J:152701
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc Vangl2Lp/Vangl2+ B6.Cg-Vangl2Lp Dact1tm1.1Bnrc	abnormal anus morphology	J:152701
	abnormal digestive system morphology	J:152701
	abnormal external female genitalia morphology	J:152701
	abnormal external male genitalia morphology	J:152701
	abnormal kidney morphology	J:152701
	abnormal urinary bladder morphology	J:152701
	caudal body truncation	J:152701
	curly tail	J:152701
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc Vangl2Lp/Vangl2Lp B6.Cg-Vangl2Lp Dact1tm1.1Bnrc	craniorachischisis	J:152701
Dvl1tm1Awb/Dvl1+ Dvl2tm1Awb/Dvl2tm1Awb Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * LPT/LeJ	craniorachischisis	J:108512
	neonatal lethality, complete penetrance	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb Vangl2Lp/Vangl2Lp involves: 129S6/SvEvTac * LPT/LeJ	craniorachischisis	J:108512
Dvl2tm1Awb/Dvl2tm1Awb Tg(Dvl2/EGFP)2Awb/? Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * LPT/LeJ	no abnormal phenotype detected	J:108512
Dvl2tm1Awb/Dvl2tm1Awb Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * LPT/LeJ	abnormal cochlear inner hair cell morphology	J:108512
	abnormal embryo development	J:108512
	abnormal organ of Corti morphology	J:100861
	abnormal orientation of cochlear hair cell stereociliary bundles	J:100861
	craniorachischisis	J:108512
	increased cochlear hair cell number	J:100861
	neonatal lethality, complete penetrance	J:108512
Dvl3tm1Awb/Dvl3+ Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * A * Black Swiss	abnormal neural tube morphology	J:142392
	abnormal orientation of cochlear hair cell stereociliary bundles	J:142392
	normal cardiovascular system phenotype	J:142392
	craniorachischisis	J:142392
	decreased cochlear outer hair cell number	J:142392
	exencephaly	J:142392
	incomplete rostral neuropore closure	J:142392
	increased cochlear hair cell number	J:142392
	inner ear hypoplasia	J:142392
Dvl3tm1Awb/Dvl3tm1Awb Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * A * Black Swiss	abnormal cardiac outflow tract development	J:142392
	abnormal neural tube morphology	J:142392
	abnormal orientation of cochlear hair cell stereociliary bundles	J:142392
	craniorachischisis	J:142392
	decreased cochlear outer hair cell number	J:142392
	increased cochlear hair cell number	J:142392
	inner ear hypoplasia	J:142392
Fat4tm1.1Hmc/Fat4tm1.1Hmc Vangl2Lp/Vangl2+ involves: 129P2/OlaHsd * A * FVB/N	kidney cyst	J:138247
Fzd1tm1.1Nat/Fzd1+ Vangl2Lp/Vangl2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ	open neural tube	J:165556
	ventricular septal defect	J:165556
Fzd1tm1.1Nat/Fzd1+ Fzd2tm1.1Nat/Fzd2+ Vangl2Lp/Vangl2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ	open neural tube	J:165556
	ventricular septal defect	J:165556
Fzd2tm1.1Nat/Fzd2+ Vangl2Lp/Vangl2+ involves: 129 * C57BL/6 * LPT/LeJ	abnormal heart morphology	J:189062
	ventricular septal defect	J:189062
Fzd2tm1.1Nat/Fzd2+ Fzd7tm1.1Nat/Fzd7tm1.1Nat Vangl2Lp/Vangl2+ involves: 129 * C57BL/6 * LPT/LeJ	abnormal heart morphology	J:189062
	cleft palate	J:189062
	ventricular septal defect	J:189062
Fzd2tm1.1Nat/Fzd2tm1.1Nat Vangl2Lp/Vangl2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ	abnormal cochlear hair cell morphology	J:165556
	abnormal cochlear hair cell number	J:165556
	abnormal orientation of outer hair cell stereociliary bundles	J:165556
	cleft palate	J:165556
	open neural tube	J:165556
	ventricular septal defect	J:165556
Fzd7tm1.1Nat/Fzd7tm1.1Nat Vangl2Lp/Vangl2+ involves: 129 * C57BL/6 * LPT/LeJ	abnormal heart morphology	J:189062
	cleft palate	J:189062
	ventricular septal defect	J:189062
Grhl3ct/? Vangl2Lp/Vangl2+ involves: A * GFF	abnormal astrocyte morphology	J:125330
	abnormal motor capabilities/coordination/movement	J:125330
	abnormal spinal cord morphology	J:125330
	decreased fetal weight	J:125330
	meningomyelocele	J:125330
Lrp6skax26/Lrp6+ Vangl2Lp/Vangl2+ involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J	abnormal orientation of outer hair cell stereociliary bundles	J:206979
	curly tail	J:206979
	kinked tail	J:206979
	spina bifida	J:206979
Prickle1tm1Nue/Prickle1+ Vangl2Lp/Vangl2+ involves: C57BL/6J * CBA * LPT/LeJ	abnormal embryonic epiblast morphology	J:151993
Ptk7chz/Ptk7+ Vangl2Lp/Vangl2+ involves: A * BALB/cAnN * C3H/HeH	craniorachischisis	J:163834
	spina bifida	J:163834
Rpl10aem2Mbar/Rpl10a+ Vangl2Lp/Vangl2+ involves: A * C57BL/6	spina bifida	J:328993
ScribCrc/Scrib+ Vangl2Lp/Vangl2+ C3H.Cg-Vangl2Lp ScribCrc	abnormal abdominal wall morphology	J:216413
	abnormal developmental patterning	J:216413
	abnormal eyelid morphology	J:216413
	craniorachischisis	J:216413
	curly tail	J:216413
	exencephaly	J:216413
	prenatal lethality, incomplete penetrance	J:216413
ScribCrc/Scrib+ Vangl2+/Vangl2Lp involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR	craniorachischisis	J:72608
	curly tail	J:72608
	spina bifida	J:72608
Scribcrn2/Scrib+ Vangl2Lp/Vangl2+ involves: A/J * FVB/N	craniorachischisis	J:174027
	curly tail	J:174027
Sec24bY613X/Sec24b+ Vangl2Lp/Vangl2+ involves: A * C3H/He * C57BL/6	lethality throughout fetal growth and development, incomplete penetrance	J:158452
	postnatal lethality, incomplete penetrance	J:158452
	spina bifida	J:158452
Sestd1tm1.1Bnrc/Sestd1+ Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * A * C57BL/6NCr	curly tail	J:201925
Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * A * C57BL/6NCr	abnormal reproductive system development	J:201925
	abnormal urinary system development	J:201925
	curly tail	J:201925
	short tail	J:201925
Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2+ Sfrp5tm1Aksh/Sfrp5tm1Aksh Vangl2Lp/Vangl2+ involves: 129 * A * C57BL/6 * LPT/LeJ	spina bifida	J:135313
Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2tm1Aksh Sfrp5tm1Aksh/Sfrp5+ Vangl2Lp/Vangl2+ involves: 129 * A * C57BL/6 * LPT/LeJ	abnormal rostral-caudal body axis extension	J:135313
	abnormal somite development	J:135313
	craniorachischisis	J:135313
	open neural tube	J:135313
Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp5tm1Aksh/Sfrp5tm1Aksh Vangl2Lp/Vangl2+ involves: 129 * A * C57BL/6 * LPT/LeJ	spina bifida	J:135313
Usp39em1Imat/Usp39+ Vangl2Lp/Vangl2Lp involves: A * CD-1	abnormal limb development	J:324183
	short rostral-caudal axis	J:324183
Vangl1Gt(XL802)Byg/Vangl1+ Vangl2Lp/Vangl2+ involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ	abnormal cochlea morphology	J:132697
	abnormal cochlear hair cell stereociliary bundle morphology	J:132697
	abnormal orientation of inner hair cell stereociliary bundles	J:132697
	abnormal orientation of outer hair cell stereociliary bundles	J:132697
	normal cardiovascular system phenotype	J:132697
	craniorachischisis	J:132697
	curly tail	J:132697
	perinatal lethality, incomplete penetrance	J:132697
	retroesophageal right subclavian artery	J:132697
Vangl1Gt(XL802)Byg/Vangl1+ Vangl2ska17/Vangl2+ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:169664
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg Vangl2Lp/Vangl2+ involves: 129P2/OlaHsd * A	abnormal cochlear inner hair cell morphology	J:162640
	abnormal cochlear outer hair cell morphology	J:162640
	female infertility	J:162640
	short tail	J:162640
	vagina atresia	J:162640
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg Vangl2tm1.2Yy/Vangl2+ involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cochlear outer hair cell morphology	J:162640
	long tail	J:162640
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg Vangl2tm1.2Yy/Vangl2tm1.2Yy involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cochlear inner hair cell morphology	J:162640
	abnormal cochlear outer hair cell morphology	J:162640
	abnormal embryo turning	J:162640
	abnormal embryonic cilium location or orientation	J:162640
	abnormal motile primary cilium physiology	J:162640
	abnormal notochord morphology	J:162640
	abnormal prenatal body size	J:162640
	failure of heart looping	J:162640
	heterotaxia	J:162640
	left pulmonary isomerism	J:162640
Vangl2Lp/Vangl2+ Ptk7Gt(Betageo)1Matl/Ptk7+ involves: 129P2/Ola * C57BL/6 * LPT/LeJ	normal hearing/vestibular/ear phenotype	J:91298
	spina bifida	J:91298
Vangl2Lp/Vangl2+ MkksGt(OST367255)Lex/Mkks+ involves: 129S5/SvEvBrd * C57BL/6J * LPT/LeJ	abnormal orientation of outer hair cell stereociliary bundles	J:102697
	abnormal outer hair cell stereociliary bundle morphology	J:102697
	embryonic lethality during organogenesis, complete penetrance	J:102697
Vangl2Lp/Vangl2Lp Tg(Dvl2/EGFP)2Awb/? involves: LPT/LeJ	abnormal organ of Corti morphology	J:100861