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Sfrp1tm1Aksh
Targeted Allele Detail
Summary
Symbol: Sfrp1tm1Aksh
Name: secreted frizzled-related protein 1; targeted mutation 1, Akihiko Shimono
MGI ID: MGI:3621116
Synonyms: Sfrp1-
Gene: Sfrp1  Location: Chr8:23901518-23939648 bp, + strand  Genetic Position: Chr8, 11.48 cM
Alliance: Sfrp1tm1Aksh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-T-lacZ-bpA cassette replaced the first exon, which encodes the functional domain of the protein. Beta-gal staining confirmed that expression reflected endogenous protein expression. Transcript was not detected in mutants. (J:106551)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sfrp1 Mutation:  17 strains or lines available
References
Original:  J:106551 Satoh W, et al., Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory