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Sfrp2tm1Aksh
Targeted Allele Detail
Summary
Symbol: Sfrp2tm1Aksh
Name: secreted frizzled-related protein 2; targeted mutation 1, Akihiko Shimono
MGI ID: MGI:3621117
Synonyms: Sfrp2-
Gene: Sfrp2  Location: Chr3:83673628-83681621 bp, + strand  Genetic Position: Chr3, 37.37 cM
Alliance: Sfrp2tm1Aksh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 1 of the locus, which encodes the functional domain of the protein, with a loxP-flanked PGK-neopbA. Transcript was not detected in mutants. (J:106551)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sfrp2 Mutation:  26 strains or lines available
References
Original:  J:106551 Satoh W, et al., Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory