Rpl10a^em2Mbar
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rpl10a^em2Mbar
• Name: ribosomal protein L10A; endonuclease-mediated mutation 2, Maria Barna
• MGI ID: MGI:7385086
• Synonyms: Rpl10a^extended, Rpl10a^LOF
• Gene: Rpl10a Location: Chr17:28547557-28550007 bp, + strand Genetic Position: Chr17, 14.65 cM
• Alliance: Rpl10a^em2Mbar page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Insertion
• CRISPR-targeting of intron 1 deletes 279 nucleotides resulting in the insertion of 38 amino acids. (J:328993)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpl10a Mutation: 50 strains or lines available

References

• Original: J:328993 Genuth NR, et al., A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production. Nat Commun. 2022 Sep 19;13(1):5491
• All: 1 reference(s)