54 phenotypes from 8 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atg16l1Gt(BC0122)Wtsi/Atg16l1Gt(BC0122)Wtsi involves: 129P2/OlaHsd * C57BL/6	abnormal Paneth cell morphology	J:141419
	impaired autophagy	J:141419
	normal reproductive system phenotype	J:141419
Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi involves: 129P2/OlaHsd * C57BL/6	abnormal Paneth cell morphology	J:141419
	impaired autophagy	J:141419
Atg16l1tm1.1Mvlc/Atg16l1tm1.1Mvlc C57BL/6-Atg16l1tm1.1Mvlc	abnormal macrophage physiology	J:206931
	normal digestive/alimentary phenotype	J:206931
	normal immune system phenotype	J:206931
	impaired autophagy	J:206931
	increased circulating interleukin-1 beta level	J:206931
	increased macrophage cytokine production	J:206931
	increased susceptibility to bacterial infection	J:206931
Atg16l1tm1a(EUCOMM)Wtsi/Atg16l1+ C57BL/6N-Atg16l1tm1a(EUCOMM)Wtsi/Wtsi	increased circulating serum albumin level	J:175295
	increased mean corpuscular hemoglobin	J:175295
Atg16l1tm1a(EUCOMM)Wtsi/Atg16l1tm1a(EUCOMM)Wtsi C57BL/6N-Atg16l1tm1a(EUCOMM)Wtsi/Wtsi	abnormal eye muscle morphology	J:239583
	abnormal hepatic vein morphology	J:239583
	abnormal hypoglossal nerve topology	J:239583
	abnormal inferior vena cava valve morphology	J:239583
	abnormal intrathoracic topology of vagus nerve	J:239583
	abnormal thymus topology	J:239583
	abnormal vitelline vein topology	J:239583
	absent connection between subcutaneous lymph vessels and lymph sac	J:239583
	absent ductus venosus valve	J:239583
	absent hypoglossal nerve	J:239583
	absent segment of posterior cerebral artery	J:239583
	blood in lymph vessels	J:239583
	overriding aortic valve	J:239583
	perimembraneous ventricular septal defect	J:239583
	preweaning lethality, complete penetrance	J:211773
	subcutaneous edema	J:239583
	thoracoschisis	J:239583
Atg16l1tm1a(EUCOMM)Wtsi/Atg16l1tm1a(EUCOMM)Wtsi involves: C57BL/6N	prenatal lethality	J:221019
Atg16l1tm1Aki/Atg16l1tm1Aki involves: 129/Sv * C57BL/6	abnormal autophagosome formation	J:141420
	abnormal macrophage physiology	J:141420
	impaired autophagy	J:141420
	increased interleukin-1 beta secretion	J:141420
	increased interleukin-18 secretion	J:141420
	increased susceptibility to induced colitis	J:141420
	neonatal lethality, complete penetrance	J:141420
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi Pgrtm2(cre)Lyd/Pgr+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	abnormal decidualization	J:287978
	decreased litter size	J:287978
	impaired embryo implantation	J:287978
	reduced female fertility	J:287978
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi Tg(Defa6-icre)1Rsb/0 involves: C57BL/6	abnormal intestine physiology	J:340266
	increased susceptibility to colitis induced morbidity/mortality	J:340266
	increased susceptibility to induced colitis	J:340266
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi Tg(Itgax-cre)1-1Reiz/? involves: C57BL/6 * C57BL/6N * CBA	normal cellular phenotype	J:221019
	normal immune system phenotype	J:221019
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi Tg(Vil1-cre)997Gum/? involves: C57BL/6J * C57BL/6N * SJL	abnormal autophagy	J:221019
	abnormal chemokine level	J:221019
	abnormal circulating interleukin level	J:221019
	abnormal cytokine level	J:221019
	abnormal Paneth cell morphology	J:221019
	cecum inflammation	J:221019
	decreased Paneth cell number	J:221019
	increased circulating interleukin-1 beta level	J:221019
	increased circulating interleukin-6 level	J:221019
	increased macrophage cell number	J:221019
	increased susceptibility to bacterial infection	J:221019
Atg16l1tm1Kuv/Atg16l1tm1Kuv Tg(Vil1-cre)997Gum/0 B6.Cg-Atg16l1tm1Kuv Tg(Vil1-cre)997Gum	decreased body weight	J:269933
	increased enterocyte apoptosis	J:269933
	increased susceptibility to induced colitis	J:269933
	small intestinal inflammation	J:269933
Atg16l1tm1Kuv/Atg16l1tm1Kuv Tg(Vil1-cre)997Gum/0 involves: C57BL/6 * SJL	abnormal autophagy	J:206084
	abnormal enterocyte morphology	J:206084
	abnormal enterocyte physiology	J:206084
	abnormal Paneth cell morphology	J:206084
Atg16l1tm2.1Mvlc/Atg16l1tm2.1Mvlc Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6	impaired autophagy	J:206931