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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxa2
forkhead box A2
MGI:1347476
115 phenotypes from 9 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxa2tm1(cre)Heli/Foxa2tm1(cre)Heli
B6.129S2-Foxa2tm1(cre)Heli 		normal mortality/aging J:142568
Foxa2tm1(cre/ERT2)Hssk/Foxa2tm1(cre/ERT2)Hssk
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * ICR 		no abnormal phenotype detected J:194054
Foxa2tm1.1Khk/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		abnormal respiratory mucosa goblet cell morphology J:284174
increased susceptibility to injury J:284174
respiratory system inflammation J:284174
Foxa2tm1.1Stf/Foxa2tm1.1Stf
B6.129-Foxa2tm1.1Stf 		hyperactivity J:155391
increased carbon dioxide production J:155391
increased fluid intake J:155391
increased food intake J:155391
increased oxygen consumption J:155391
Foxa2tm1.1Stf/Foxa2tm1.1Stf
Tg(Nes-cre)1Kln/0
B6.Cg-Foxa2tm1.1Stf Tg(Nes-cre)1Kln 		decreased circulating free fatty acids level J:155391
decreased circulating glucose level J:155391
decreased circulating insulin level J:155391
decreased total body fat amount J:155391
hyperactivity J:155391
improved glucose tolerance J:155391
increased basal metabolism J:155391
increased carbon dioxide production J:155391
increased fluid intake J:155391
increased food intake J:155391
increased insulin sensitivity J:155391
increased lean body mass J:155391
increased oxygen consumption J:155391
Foxa2tm1Dnl/Foxa2+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal gait J:19896
abnormal glucose homeostasis J:95662
abnormal metabolism J:95662
absent estrous cycle J:19896
absent estrus J:19896
impaired righting response J:19896
increased circulating free fatty acids level J:95662
increased circulating triglyceride level J:95662
increased liver triglyceride level J:95662
increased miscarriage rate J:19896
malocclusion J:19896
neonatal lethality, incomplete penetrance J:19896
reduced female fertility J:19896
Foxa2tm1Dnl/Foxa2tm1Dnl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cell death J:19896
abnormal chordamesoderm morphology J:19896
abnormal embryonic tissue morphology J:19896
abnormal endoderm development J:19896
abnormal eye development J:19896
abnormal nervous system development J:19896
abnormal neural tube morphology J:19896
abnormal neuron differentiation J:19896
abnormal paraxial mesoderm morphology J:19896
abnormal somite development J:19896
absent floor plate J:19896
absent notochord J:19896
absent primitive node J:19896
decreased embryo size J:19896
embryonic lethality during organogenesis, complete penetrance J:19896
Foxa2tm1Jrt/Foxa2+
involves: 129S1/Sv * 129X1/SvJ 		circling J:19895
decreased body size J:19895
hunched posture J:19895
long incisors J:19895
malocclusion J:19895
postnatal lethality J:19895
premature death J:19895
Foxa2tm1Jrt/Foxa2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		circling J:19895
decreased body size J:19895
hunched posture J:19895
long incisors J:19895
malocclusion J:19895
postnatal lethality J:19895
premature death J:19895
Foxa2tm1Jrt/Foxa2+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		circling J:19895
decreased body size J:19895
hunched posture J:19895
long incisors J:19895
malocclusion J:19895
postnatal lethality J:19895
premature death J:19895
Foxa2tm1Jrt/Foxa2tm1Jrt
involves: 129S1/Sv * 129X1/SvJ 		abnormal primitive streak elongation J:74124
abnormal primitive streak formation J:74124
abnormal rostral-caudal axis patterning J:74124
absent primitive node J:74124
Foxa2tm1Jrt/Foxa2tm1Jrt
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		absent mesoderm J:50810
increased embryonic tissue cell apoptosis J:50810
Foxa2tm1Jrt/Foxa2tm1Jrt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal developmental patterning J:19895
abnormal embryonic tissue morphology J:19895
abnormal foregut morphology J:19895
abnormal neural tube morphology J:19895
abnormal primitive endoderm morphology J:19895
abnormal primitive streak formation J:19895
abnormal rostral-caudal axis patterning J:19895
abnormal somite shape J:19895
absent floor plate J:19895
absent mesoderm J:50810
absent notochord J:19895
absent primitive node J:19895
decreased somite size J:19895
embryonic lethality during organogenesis, complete penetrance J:19895
embryonic-extraembryonic boundary constriction J:19895
fused somites J:19895
increased embryonic tissue cell apoptosis J:50810
kinked neural tube J:19895
rostral body truncation J:19895
Foxa2tm1Jrt/Foxa2tm1Khk
Tg(Nes-cre)1Wme/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal forebrain morphology J:75055
abnormal mesendoderm development J:75055
embryonic lethality during organogenesis, complete penetrance J:75055
Foxa2tm1Khk/Foxa2tm1Khk
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA 		abnormal insulin secretion J:70409
abnormal pancreatic beta cell morphology J:70409
decreased circulating glucagon level J:70409
disorganized pancreatic islets J:70409
hypoglycemia J:70409
increased circulating insulin level J:70409
increased glycogen level J:70409
postnatal growth retardation J:70409
postnatal lethality, complete penetrance J:70409
seizures J:70409
Foxa2tm1Khk/Foxa2tm1Khk
involves: 129P2/OlaHsd * CD-1 		no abnormal phenotype detected J:63039
Foxa2tm1Khk/Foxa2tm1Khk
Pgrtm2(cre)Lyd/Pgr+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal decidualization J:165229
abnormal embryo invasion J:165229
abnormal endometrial gland development J:165229
abnormal uterus physiology J:165229
decreased endometrial gland number J:165229
decreased litter size J:165229
impaired embryo implantation J:165229
reduced female fertility J:165229
Foxa2tm1Khk/Foxa2tm1Khk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA 		no abnormal phenotype detected J:63039
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Foxa3-cre)1Khk/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA 		decreased body size J:96332
decreased circulating glucagon level J:96332
decreased pancreatic alpha cell number J:96332
decreased skin turgor J:96332
disorganized pancreatic islets J:96332
hypoglycemia J:96332
postnatal lethality, complete penetrance J:96332
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-cre)1Jaw/0
Not Specified 		abnormal respiratory mechanics J:88601
decreased lung compliance J:88601
normal immune system phenotype J:88601
increased airway resistance J:88601
increased respiratory mucosa goblet cell number J:88601
Foxa2tm1Khk/Foxa2tm1Khk
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal lung saccule morphology J:93473
abnormal pulmonary alveolus epithelial cell morphology J:93473
abnormal pulmonary alveolus wall morphology J:93473
abnormal surfactant composition J:93473
abnormal surfactant secretion J:93473
abnormal type II pneumocyte morphology J:93473
absent alveolar lamellar bodies J:93473
absent type I pneumocytes J:93473
atelectasis J:93473
cyanosis J:93473
decreased surfactant secretion J:93473
dilated respiratory conducting tube J:88601
impaired lung alveolus development J:88601, J:93473
increased macrophage cell number J:88601
increased neutrophil cell number J:88601
increased respiratory mucosa goblet cell number J:88601
neonatal lethality, incomplete penetrance J:93473
postnatal lethality, incomplete penetrance J:88601, J:93473
pulmonary hyaline membrane formation J:93473
pulmonary vascular congestion J:93473
pup cannibalization J:93473
respiratory distress J:93473
Foxa2tm2(cre/Esr1*)Moon/Foxa2tm2(cre/Esr1*)Moon
Not Specified 		abnormal craniofacial development J:130990
delayed heart development J:130990
embryonic lethality, complete penetrance J:130990
Foxa2tm2.1Heli/Foxa2tm2.1Heli
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL 		no abnormal phenotype detected J:204475
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory