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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Stk11
serine/threonine kinase 11
MGI:1341870
32 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh
Nrastm1.1Nesh/Nrastm1.1Nesh
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Tg(Tyr-cre/ERT2)13Bos/0
B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Stk11tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos
increased cutaneous melanoma incidence J:220627
increased metastatic potential J:220627
Krastm4Tyj/Kras+
Stk11tm1.1Rdp/Stk11tm1.1Rdp
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
increased lung adenocarcinoma incidence J:124682
increased lung large cell carcinoma incidence J:124682
increased lung squamous cell carcinoma incidence J:124682
increased lung tumor incidence J:124682
increased metastatic potential J:124682
premature death J:124682
Krastm4Tyj/Kras+
Stk11tm1.1Rdp/Stk11tm1.2Rdp
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
increased lung adenocarcinoma incidence J:124682
increased lung large cell carcinoma incidence J:124682
increased lung squamous cell carcinoma incidence J:124682
increased lung tumor incidence J:124682
increased metastatic potential J:124682
premature death J:124682
Krastm4Tyj/Kras+
Stk11tm1.2Rdp/Stk11tm1.2Rdp
involves: 129S4/SvJae * 129S6/SvEvTac
increased macrophage cell number J:197037
Krastm4Tyj/Kras+
Stk11tm1.1Gne/Stk11tm1.1Gne
involves: 129S4/SvJae * C57BL/6N
pancreas cysts J:195229
Pdx1tm1Egs/Pdx1+
Stk11tm1.1Gne/Stk11tm1.1Gne
involves: 129S1/Sv * C57BL/6N
increased cell proliferation J:195229
pancreas cysts J:195229
Ptentm2Mak/Ptentm2Mak
Stk11tm1Keis/Stk11tm1Keis
Tg(Cyp1a1-cre/ERT)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
abnormal urinary bladder mucosa morphology J:169565
abnormal urinary bladder urothelium morphology J:169565
enlarged urinary bladder J:169565
increased urinary bladder carcinoma incidence J:169565
premature death J:169565
urinary bladder obstruction J:169565
Ptgs2tm1Jed/Ptgs2+
Stk11tm1Tpm/Stk11+
involves: 129S7/SvEvBrd * C57BL/6 * CD-1
gastric polyps J:93361
intestine polyps J:93361
Ptgs2tm1Jed/Ptgs2tm1Jed
Stk11tm1Tpm/Stk11+
involves: 129S7/SvEvBrd * C57BL/6 * CD-1
decreased tumor incidence J:93361
gastric polyps J:93361
intestine polyps J:93361
Stk11tm1.1Mlfr/Stk11+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
distended abdomen J:104347
gastric polyps J:104347
increased hamartoma incidence J:104347
increased lymphoma incidence J:104347
increased osteosarcoma incidence J:104347
increased sarcoma incidence J:104347
premature death J:104347
Stk11tm1.1Mlfr/Stk11+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
colon polyps J:104347
increased hamartoma incidence J:104347
premature death J:104347
Stk11tm1Mmt/Stk11+
Trp53tm1Brd/Trp53+
involves: 129S7/SvEvBrd * 129X1/SvJ
increased hamartoma incidence J:107275
Stk11tm1Mmt/Stk11+
Trp53tm1Brd/Trp53tm1Brd
involves: 129S7/SvEvBrd * 129X1/SvJ
abnormal hepatocyte morphology J:107275
increased hamartoma incidence J:107275
increased hepatocellular carcinoma incidence J:107275
increased liver tumor incidence J:107275
increased ovary tumor incidence J:107275
increased tumor incidence J:107275
premature death J:107275
Stk11tm1Rdp/Stk11tm1Rdp
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S6/SvEvTac * C57BL/6
abnormal mammary gland morphology J:198481
decreased tumor latency J:198481
increased mammary gland tumor incidence J:198481

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory