Stk11^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1Mmt
• Name: serine/threonine kinase 11; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:2180012
• Synonyms: Lkb1-
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76202
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2-4 were replaced with a neo resistance cassette via homologous recombination. (J:76202)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1Mmt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 34 strains or lines available

References

• Original: J:76202 Miyoshi H, et al., Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res. 2002 Apr 15;62(8):2261-6
• All: 5 reference(s)