65 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
ApcMin/Apc+ Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe involves: 129S2/SvPas * C57BL/6J	decreased tumor incidence	J:152134
	increased small intestine adenocarcinoma incidence	J:152134
Cdkn1atm1Led/Cdkn1atm1Led Hdac2tm1.2Rdp/Hdac2tm1.2Rdp involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal mitosis	J:197818
	early cellular replicative senescence	J:197818
Cdkn2atm2.1Brn/Cdkn2atm2.1Brn Hdac2tm1.2Rdp/Hdac2tm1.2Rdp involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal mitosis	J:197818
Hdac1tm1.1Eno/Hdac1tm1.1Eno Hdac2tm1.1Eno/Hdac2+ Tg(KRT14-cre)1Ipc/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal coat appearance	J:205733
	abnormal epidermal layer morphology	J:205733
	abnormal nail color	J:205733
	abnormal nail morphology	J:205733
	abnormal vibrissa morphology	J:205733
	hyperkeratosis	J:205733
	increased foot pad pigmentation	J:205733
	narrow eye opening	J:205733
	short vibrissae	J:205733
Hdac1tm1.1Eno/Hdac1tm1.1Eno Hdac2tm1.1Eno/Hdac2tm1.1Eno Tg(Myh6-cre)2182Mds/? involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N	dilated heart ventricle	J:123173
	increased cardiomyocyte apoptosis	J:123173
	irregular heartbeat	J:123173
	postnatal lethality, incomplete penetrance	J:123173
Hdac1tm1.1Mrl/Hdac1tm1.1Mrl Hdac2tm1.1Rdp/Hdac2+ Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	abnormal megakaryocyte morphology	J:197818
	anemia	J:197818
	decreased bone marrow cell number	J:197818
	decreased erythrocyte cell number	J:197818
	decreased megakaryocyte cell number	J:197818
	lethargy	J:197818
	thrombocytopenia	J:197818
Hdac1tm1.1Mrl/Hdac1tm1.1Mrl Hdac2tm1.1Rdp/Hdac2tm1.1Rdp Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal mitosis	J:197818
	decreased fibroblast proliferation	J:197818
	early cellular replicative senescence	J:197818
Hdac1tm1.1Mrl/Hdac1tm1.1Mrl Hdac2tm1.1Rdp/Hdac2tm1.1Rdp Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	anemia	J:197818
	decreased bone marrow cell number	J:197818
	decreased erythrocyte cell number	J:197818
	decreased megakaryocyte cell number	J:197818
	increased apoptosis	J:197818
	internal hemorrhage	J:197818
	lethargy	J:197818
	premature death	J:197818
	thrombocytopenia	J:197818
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt Hdac2tm1.1Pmt/Hdac2tm1.1Pmt involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal cell cycle	J:157903
	increased fibroblast apoptosis	J:157903
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt Hdac2tm1.1Pmt/Hdac2tm1.1Pmt Cd79atm1(cre)Reth/Cd79a+ involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N	abnormal spleen morphology	J:157903
	arrested B cell differentiation	J:157903
	decreased B cell number	J:157903
	decreased bone marrow cell number	J:157903
	decreased pre-B cell number	J:157903
	decreased pro-B cell number	J:157903
	increased B cell apoptosis	J:157903
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt Hdac2tm1.1Pmt/Hdac2tm1.1Pmt Tg(Fcer2a-cre)5Mbu/0 involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N	decreased B cell proliferation	J:157903
	increased B cell apoptosis	J:157903
Hdac1tm1.1Shmc/Hdac1+ Hdac2tm1.1Shmc/Hdac2tm1.1Shmc Tg(Lck-cre)1Cwi/0 involves: 129S7/SvEvBrd	normal immune system phenotype	J:194769
Hdac1tm1.1Shmc/Hdac1tm1.1Shmc Hdac2tm1.1Shmc/Hdac2+ Tg(Lck-cre)1Cwi/0 involves: 129S7/SvEvBrd	arrested T cell differentiation	J:194769
	decreased CD4-positive, alpha-beta T cell number	J:194769
	decreased CD8-positive, alpha-beta T cell number	J:194769
	decreased double-positive T cell number	J:194769
	distended abdomen	J:194769
	enlarged chest	J:194769
	enlarged spleen	J:194769
	enlarged thymus	J:194769
	increased double-negative T cell number	J:194769
	increased double-positive T cell number	J:194769
	increased pulmonary respiratory rate	J:194769
	increased single-positive T cell number	J:194769
	increased tumor incidence	J:194769
	premature death	J:194769
	thymus hypoplasia	J:194769
Hdac1tm1.1Shmc/Hdac1tm1.1Shmc Hdac2tm1.1Shmc/Hdac2tm1.1Shmc Tg(Lck-cre)1Cwi/0 involves: 129S7/SvEvBrd	abnormal thymus corticomedullary boundary morphology	J:194769
	aneuploidy	J:194769
	arrested T cell differentiation	J:194769
	chromosomal instability	J:194769
	decreased double-positive T cell number	J:194769
	decreased thymocyte number	J:194769
	distended abdomen	J:194769
	enlarged chest	J:194769
	enlarged spleen	J:194769
	enlarged thymus	J:194769
	increased double-positive T cell number	J:194769
	increased pulmonary respiratory rate	J:194769
	increased single-positive T cell number	J:194769
	increased T cell derived lymphoma incidence	J:194769
	increased T cell proliferation	J:194769
	increased thymocyte apoptosis	J:194769
	increased thymocyte number	J:194769
	increased tumor incidence	J:194769
	premature death	J:194769
	trisomy	J:194769
Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe Tg(Myh6-Hod)3Joe/? Not Specified	cardiac hypertrophy	J:121697
	enlarged heart	J:121697
Hdac2tm1.1Eem/Hdac2tm1.1Eem Pou5f1tm2Jae/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal cell physiology	J:171358
Mapttm2(Hdac1)Jae/Mapttm2(Hdac1)Jae involves: 129S4/SvJae * C57BL/6	abnormal hippocampus pyramidal cell morphology	J:148391