51 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn Hes1tm1.1Sat/Hes1+ Tg(Vil1-cre)997Gum/0 involves: 129S4/SvJae * C57BL/6NTac * SJL	normal digestive/alimentary phenotype	J:236761
Emx1tm1(cre)Ito/Emx1+ Hes1tm1Fgu/Hes1tm1Hojo Hes5tm1Fgu/Hes5tm1Fgu involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal neurohypophysis morphology	J:121843
	abnormal pituitary diverticulum morphology	J:121843
	abnormal pituitary gland development	J:121843
	abnormal pituitary gland morphology	J:121843
	abnormal pituitary infundibular stalk morphology	J:121843
	absent pituitary intermediate lobe	J:121843
	increased somatotroph cell number	J:121843
	pituitary gland hypoplasia	J:121843
Emx1tm1(cre)Ito/Emx1+ Hes1tm1Kag/Hes1tm1Kag Hes3tm1Kag/Hes3tm1Kag Hes5tm1Fgu/Hes5tm1Fgu involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal brain morphology	J:139170
	abnormal embryonic neuroepithelium morphology	J:139170
	abnormal neuron differentiation	J:139170
	absent choroid plexus	J:139170
	increased Cajal-Retzius cell number	J:139170
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Hes1tm1(cre/ERT2)Lcm/Hes1+ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	abnormal pancreas development	J:169830
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Hes1tm1.1Frad/Hes1tm1.1Frad Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJaeSor * C57BL/6 * CBA	decreased B cell number	J:167000
	decreased lymphoma incidence	J:167000
Hes1tm1Fgu/Hes1+ Hes5tm1Fgu/Hes5tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1	increased cochlear outer hair cell number	J:70081
Hes1tm1Fgu/Hes1tm1Fgu Hes3tm1Kag/Hes3tm1Kag involves: C57BL/6 * CBA * ICR	abnormal brain development	J:71074
	abnormal dopaminergic neuron morphology	J:71074
	abnormal locus ceruleus morphology	J:71074
	abnormal midbrain morphology	J:71074
	abnormal midbrain-hindbrain boundary morphology	J:71074
	abnormal neural tube morphology	J:71074
	abnormal oculomotor nucleus morphology	J:71074
	absent oculomotor nerve	J:71074
	absent trochlear nerve	J:71074
	embryonic growth retardation	J:71074
	exencephaly	J:71074
	lethality throughout fetal growth and development, complete penetrance	J:71074
	premature neuronal precursor differentiation	J:71074
Hes1tm1Fgu/Hes1tm1Fgu Hes3tm1Kag/Hes3tm1Kag Hes5tm1Fgu/Hes5tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1	premature neuronal precursor differentiation	J:94391
Hes1tm1Fgu/Hes1tm1Fgu Hes5tm1Fgu/Hes5+ involves: 129S1/Sv * 129X1/SvJ * CD-1	increased cochlear inner hair cell number	J:70081
Hes1tm1Fgu/Hes1tm1Fgu Hes5tm1Fgu/Hes5tm1Fgu involves: 129S1/Sv * 129X1/SvJ	abnormal choroid plexus morphology	J:139170
Hes1tm1Fgu/Hes1tm1Fgu Hes5tm1Fgu/Hes5tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal astrocyte morphology	J:94391
	abnormal brain development	J:94391
	abnormal CNS glial cell morphology	J:94391
	abnormal dorsal root ganglion morphology	J:94391
	abnormal embryonic/fetal subventricular zone morphology	J:94391
	abnormal ependyma morphology	J:94391
	abnormal forebrain morphology	J:94391
	abnormal nasal placode morphology	J:62024
	abnormal neural tube morphology	J:62024, J:94391
	abnormal spinal cord morphology	J:94391
	absent oligodendrocytes	J:94391
	absent optic vesicle	J:94391
	decreased embryo size	J:54662
	embryonic lethality during organogenesis, incomplete penetrance	J:94391
	neuron hypertrophy	J:54662
	premature neuronal precursor differentiation	J:94391
Hes1tm1Kag/Hes1tm1Kag Hes3tm1Kag/Hes3tm1Kag Hes5tm1Fgu/Hes5tm1Fgu Tg(Nes-cre/ERT2)5-1Kag/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	normal nervous system phenotype	J:139170
Rbpjtm1Hon/Rbpjtm1.1Hon Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Hes1tm1(cre/ERT2)Lcm/Hes1+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal centroacinar cell of Langerhans morphology	J:180310
	abnormal pancreas physiology	J:180310
	normal endocrine/exocrine gland phenotype	J:180310
	increased pancreatic acinar cell number	J:180310