Hes1^tm1.1Sat
Targeted Allele Detail

Summary

• Symbol: Hes1^tm1.1Sat
• Name: hes family bHLH transcription factor 1; targeted mutation 1.1, Spyros Artavanis-Tsakonas
• MGI ID: MGI:5304919
• Synonyms: Hes1-EmGFP^SAT, Hes1-GFP
• Gene: Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
• Alliance: Hes1^tm1.1Sat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179632
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A targeting vector was designed to insert the open reading frame of emerald GFP (EmGFP), a polyadenylation sequence and an Frt-flanked neo selection cassette, resulting in replacement of the exon 1 coding region. Chimeric males were bred to Flpe-expressing females to excise the selection cassette. (J:179632)

Generation of the Hes1^tm1.1Sat allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hes1 Mutation: 23 strains or lines available

References

• Original: J:179632 Fre S, et al., Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One. 2011;6(10):e25785
• All: 12 reference(s)