Brca1tm1.1Brn/Brca1tm1.1Brn
involves: 129P2/OlaHsd * BALB/cJ * FVB/N
|
prenatal lethality, complete penetrance |
J:126551
|
Brca1tm1.1Jjon/Brca1tm1.1Jjon
involves: C57BL/6J
|
embryonic growth retardation |
J:178595
|
|
embryonic lethality during organogenesis, complete penetrance |
J:178595
|
Brca1tm1Aash/Brca1tm1Aash
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
no abnormal phenotype detected |
J:119996
|
Brca1tm1Aash/Brca1tm1Aash
Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
increased mammary gland tumor incidence |
J:119996
|
|
increased salivary adenocarcinoma incidence |
J:119996
|
Brca1tm1Arge/Brca1+
involves: 129S/SvEv * C57BL/6
|
no abnormal phenotype detected |
J:40594
|
Brca1tm1Arge/Brca1tm1Arge
involves: 129S/SvEv * C57BL/6
|
abnormal egg cylinder morphology |
J:40594
|
|
abnormal embryonic tissue morphology |
J:40594
|
|
absent amniotic folds |
J:40594
|
|
absent mesoderm |
J:40594
|
|
embryonic growth retardation |
J:40594
|
|
embryonic lethality, complete penetrance |
J:40594
|
|
empty decidua capsularis |
J:40594
|
Brca1tm1Arge/Brca1tm1Arge
Tg(Hsp70-1-cre)1Arge/0
involves: 129S/SvEv * C57BL/6J * CBA
|
embryonic lethality, complete penetrance |
J:134977
|
Brca1tm1Arge/Brca1tm1Thl
Waptm1(cre)Arge/0
involves: 129S/SvEv * 129S1/Sv * C57BL/6J
|
increased mammary adenocarcinoma incidence |
J:134977
|
Brca1tm1Bhk/Brca1+
C.129P2-Brca1tm1Bhk
|
decreased body weight |
J:198018
|
|
decreased mammary gland epithelial cell proliferation |
J:198018
|
|
early cellular replicative senescence |
J:198018
|
|
increased mammary gland tumor incidence |
J:198018
|
Brca1tm1Bhk/Brca1+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
no abnormal phenotype detected |
J:31571
|
Brca1tm1Bhk/Brca1tm1Bhk
involves: 129P2/OlaHsd * BALB/c * C57BL/6
|
embryonic lethality during organogenesis, complete penetrance |
J:74077
|
|
open neural tube |
J:74077
|
Brca1tm1Bhk/Brca1tm1Bhk
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
abnormal embryonic neuroepithelial layer differentiation |
J:31571
|
|
decreased embryo size |
J:31571
|
|
embryonic lethality during organogenesis, complete penetrance |
J:31571
|
|
exencephaly |
J:31571
|
|
open neural tube |
J:31571
|
|
spina bifida |
J:31571
|
Brca1tm1Brn/Brca1tm1Brn
involves: 129P2/OlaHsd
|
abnormal cell death |
J:117113
|
|
abnormal ovary morphology |
J:117113
|
|
decreased cell proliferation |
J:117113
|
Brca1tm1Brn/Brca1tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * BALB/cJ * FVB/N
|
normal
neoplasm |
J:126551
|
Brca1tm1Cxd/Brca1tm1Cxd
either: 129S6/SvEvTac-Brca1tm1Cxd or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
|
abnormal axial mesoderm morphology |
J:51834
|
|
abnormal chromosome number |
J:51834
|
|
abnormal embryonic tissue morphology |
J:51834
|
|
abnormal primitive streak formation |
J:51834
|
|
decreased embryo size |
J:51834
|
|
embryonic lethality between implantation and placentation, complete penetrance |
J:51834
|
|
increased cellular sensitivity to gamma-irradiation |
J:51834
|
Brca1tm1Cxd/Brca1tm1Cxd
involves: 129S6/SvEvTac
|
abnormal double-strand DNA break repair |
J:269823
|
Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-cre)5132Jlj/0
involves: 129S6/SvEvTac * C57BL/6
|
abnormal epidermal layer morphology |
J:85354
|
|
increased keratinocyte proliferation |
J:85354
|
|
increased mouth tumor incidence |
J:85354
|
|
increased skin tumor incidence |
J:85354
|
|
increased squamous cell carcinoma incidence |
J:85354
|
|
increased tumor incidence |
J:85354
|
Brca1tm1Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB
|
abnormal branching of the mammary ductal tree |
J:54533
|
|
abnormal involution of the mammary gland |
J:54533
|
|
abnormal mammary gland development |
J:54533
|
|
abnormal mammary gland growth during pregnancy |
J:54533
|
|
increased mammary adenocarcinoma incidence |
J:54533
|
|
increased mammary gland tumor incidence |
J:54533
|
Brca1tm1Cxd/Brca1tm2Cxd
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss
|
abnormal branching of the mammary ductal tree |
J:54533
|
|
abnormal involution of the mammary gland |
J:54533
|
|
abnormal mammary gland development |
J:54533
|
|
abnormal mammary gland growth during pregnancy |
J:54533
|
|
increased mammary gland tumor incidence |
J:54533
|
Brca1tm1Mak/Brca1+
either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
|
no abnormal phenotype detected |
J:33880
|
Brca1tm1Mak/Brca1tm1Mak
either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
|
abnormal developmental patterning |
J:33880
|
|
abnormal embryonic tissue morphology |
J:33880
|
|
abnormal embryonic-extraembryonic boundary morphology |
J:33880
|
|
abnormal extraembryonic tissue morphology |
J:33880
|
|
abnormal parietal endoderm morphology |
J:33880
|
|
abnormal trophoblast layer morphology |
J:33880
|
|
abnormal visceral endoderm morphology |
J:33880
|
|
absent mesoderm |
J:33880
|
|
absent trophoblast giant cells |
J:33880
|
|
decreased embryo size |
J:33880
|
|
disorganized extraembryonic tissue |
J:33880
|
|
embryonic growth retardation |
J:33880
|
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:33880
|
|
failure of primitive streak formation |
J:33880
|
Brca1tm1Rfo/Brca1tm1Rfo
involves: 129P2/OlaHsd
|
abnormal developmental patterning |
J:69602
|
|
abnormal embryonic tissue morphology |
J:69602
|
|
abnormal heart development |
J:69602
|
|
embryonic growth retardation |
J:69602
|
|
embryonic lethality during organogenesis, complete penetrance |
J:67880
|
|
enlarged tail bud |
J:69602
|
|
incomplete somite formation |
J:69602
|
|
increased apoptosis |
J:69602
|
Brca1tm1Thl/Brca1tm1Thl
involves: 129 * C57BL/6J
|
no abnormal phenotype detected |
J:134977
|
Brca1tm1Thl/Brca1tm1Thl
Waptm1(cre)Arge/0
involves: 129S1/Sv * C57BL/6J
|
increased mammary adenocarcinoma incidence |
J:134977
|
Brca1tm1Whl/Brca1+
involves: 129P2/OlaHsd * C57BL/6J
|
no abnormal phenotype detected |
J:34458
|
Brca1tm1Whl/Brca1tm1Whl
involves: 129P2/OlaHsd * C57BL/6J
|
abnormal developmental patterning |
J:34458
|
|
abnormal embryonic tissue morphology |
J:34458
|
|
absent egg cylinders |
J:34458
|
|
absent mesoderm |
J:34458
|
|
decreased cell proliferation |
J:34458
|
|
decreased embryo size |
J:34458
|
|
disorganized embryonic tissue |
J:34458
|
|
embryonic growth retardation |
J:34458
|
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:34458
|
Brca1tm2.1Cxd/Brca1tm2.1Cxd
involves: 129S6/SvEvTac
|
abnormal cell adhesion |
J:134494
|
|
abnormal cell death |
J:70271
|
|
abnormal cell migration |
J:134494
|
|
abnormal nervous system morphology |
J:70271
|
|
chromosomal instability |
J:307190
|
|
decreased embryo size |
J:70271
|
|
exencephaly |
J:70271
|
|
increased apoptosis |
J:70271
|
|
increased cellular sensitivity to gamma-irradiation |
J:81541
|
|
prenatal lethality, complete penetrance |
J:70271
|
Brca1tm2.1Cxd/Brca1tm2.1Cxd
involves: 129S6/SvEvTac * C57BL/6
|
abnormal centrosome morphology |
J:177853
|
|
decreased fibroblast proliferation |
J:177853
|
|
early cellular replicative senescence |
J:177853
|
Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
|
normal
neoplasm |
J:177853
|
Brca1tm2Arge/Brca1tm2Arge
129-Brca1tm2Arge
|
abnormal skin pigmentation |
J:69187
|
|
arrest of spermatogenesis |
J:69187
|
|
increased mammary gland tumor incidence |
J:69187
|
|
increased tumor incidence |
J:69187
|
|
kinked tail |
J:69187
|
|
male infertility |
J:69187
|
|
postnatal growth retardation |
J:69187
|
Brca1tm2Arge/Brca1tm2Arge
B6.129-Brca1tm2Arge
|
prenatal lethality, incomplete penetrance |
J:69187
|
Brca1tm2Arge/Brca1tm2Arge
involves: 129
|
abnormal double-strand DNA break repair |
J:194229
|
|
increased susceptibility to xenobiotic induced morbidity/mortality |
J:194229
|
Brca1tm2Arge/Brca1tm2Arge
involves: 129 * C57BL/6
|
increased tumor incidence |
J:177853
|
Brca1tm2Arge/Brca1tm2Arge
involves: 129 * C57BL/6J
|
prenatal lethality, incomplete penetrance |
J:69187
|
Brca1tm2Arge/Brca1tm2Arge
involves: 129/Sv * C57BL/6J * MF1
|
abnormal skin pigmentation |
J:69187
|
|
arrest of spermatogenesis |
J:69187
|
|
increased mammary gland tumor incidence |
J:69187
|
|
increased tumor incidence |
J:69187
|
|
kinked tail |
J:69187
|
|
male infertility |
J:69187
|
|
postnatal growth retardation |
J:69187
|
Brca1tm2Arge/Brca1tm3.1Rjbr
involves: 129 * C57BL/6
|
normal
neoplasm |
J:177853
|
Brca1tm2Cxd/Brca1tm2Cxd
involves: 129S6/SvEvTac * NIH Black Swiss
|
no abnormal phenotype detected |
J:54533
|
Brca1tm2Cxd/Brca1tm2Cxd
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac
|
chromosome breakage |
J:197442
|
Brca1tm2Cxd/Brca1tm2Cxd
Tg(Fshr-cre)1Ldu/0
involves: C57BL/6 * C57BL/6J * DBA/2
|
kidney cyst |
J:97090
|
|
ovary cyst |
J:97090
|
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * C57BL/6 * FVB
|
abnormal mammary gland duct morphology |
J:132088
|
|
increased mammary gland epithelial cell proliferation |
J:132088
|
|
increased mammary gland tumor incidence |
J:132088
|
|
mammary gland alveolar hyperplasia |
J:132088
|
|
ureter obstruction |
J:132088
|
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
|
abnormal cell cycle checkpoint function |
J:63282
|
|
abnormal cell death |
J:63282
|
|
abnormal immune system organ morphology |
J:63282
|
|
abnormal T cell number |
J:63282
|
|
decreased double-positive T cell number |
J:63282
|
|
decreased single-positive T cell number |
J:63282
|
|
decreased T cell proliferation |
J:63282
|
|
decreased thymocyte number |
J:63282
|
|
increased cellular sensitivity to gamma-irradiation |
J:63282
|
|
increased double-negative T cell number |
J:63282
|
|
increased tumor incidence |
J:90512
|
Brca1tm2Mak/Brca1tm2Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
|
increased mammary gland tumor incidence |
J:90512
|
Brca1tm2Rjbr/Brca1tm2Rjbr
involves: 129
|
increased tumor incidence |
J:197743
|
Brca1tm2Rjbr/Brca1tm2Rjbr
involves: 129 * C57BL/6
|
abnormal centrosome morphology |
J:177853
|
|
decreased fibroblast proliferation |
J:177853
|
|
early cellular replicative senescence |
J:177853
|
|
increased tumor incidence |
J:177853
|
|
male infertility |
J:177853
|
|
normal
mortality/aging |
J:177853
|
Brca1tm3.1Rjbr/Brca1tm3.1Rjbr
involves: 129 * C57BL/6
|
arrest of spermatogenesis |
J:177853
|
|
azoospermia |
J:177853
|
|
normal
cellular phenotype |
J:177853
|
|
decreased body weight |
J:177853
|
|
male infertility |
J:177853
|
|
normal
mortality/aging |
J:177853
|
|
normal
neoplasm |
J:177853
|
|
small testis |
J:177853
|
Brca1tm4.1Rjbr/Brca1tm4.1Rjbr
involves: 129 * C57BL/6
|
normal
reproductive system phenotype |
J:177853
|
Brca1tm5.1Cxd/Brca1tm5.1Cxd
involves: 129S6/SvEvTac * FVB/N
|
abnormal branching of the mammary ductal tree |
J:155810
|
|
abnormal coat/hair pigmentation |
J:155810
|
|
abnormal hair follicle morphology |
J:155810
|
|
abnormal hair growth |
J:155810
|
|
abnormal mammary gland development |
J:155810
|
|
abnormal mammary gland lobule morphology |
J:155810
|
|
abnormal small intestinal villus morphology |
J:155810
|
|
decreased body weight |
J:155810
|
|
decreased hair follicle number |
J:155810
|
|
decreased small intestinal villus height |
J:155810
|
|
decreased subcutaneous adipose tissue amount |
J:155810
|
|
decreased survivor rate |
J:155810
|
|
dermatitis |
J:155810
|
|
hyperactivity |
J:155810
|
|
increased cellular sensitivity to gamma-irradiation |
J:155810
|
|
increased incidence of tumors by ionizing radiation induction |
J:155810
|
|
increased liver tumor incidence |
J:155810
|
|
increased lymphoma incidence |
J:155810
|
|
increased mammary gland apoptosis |
J:155810
|
|
increased mammary gland epithelial cell proliferation |
J:155810
|
|
increased mammary gland tumor incidence |
J:155810
|
|
increased mortality induced by gamma-irradiation |
J:155810
|
|
increased T cell derived lymphoma incidence |
J:155810
|
|
mammary gland hyperplasia |
J:155810
|
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