Brca1^tm4.1Rjbr
Targeted Allele Detail

Summary

• Symbol: Brca1^tm4.1Rjbr
• Name: breast cancer 1, early onset; targeted mutation 4.1, Richard J Baer
• MGI ID: MGI:5494436
• Synonyms: Brca1^FH-WT
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm4.1Rjbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: Exon 2 was replaced with a modified exon two containing an artificial initiator methionine, FLAG epitope tag and HA epitope tag. Flp-mediated recombination removed a FRT-flanked hygromycin resistance cassette inserted upstream of the modified exon 2. (J:177853, J:197744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 113 strains or lines available

References

• Original: J:177853 Shakya R, et al., BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science. 2011 Oct 28;334(6055):525-8
• All: 2 reference(s)