Brca1^tm1Rfo
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1Rfo
• Name: breast cancer 1, early onset; targeted mutation 1, Ricardo Fodde
• MGI ID: MGI:2178447
• Synonyms: Brca1(1700T)
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1Rfo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69602
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 20. RT-PCR analysis demonstrated that a mutant transcript was produced from this allele at normal expression levels. A truncated protein lacking the last BCRT repeat is predicted to be expressed from this allele. (J:69602)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm1Rfo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 113 strains or lines available

References

• Original: J:69602 Hohenstein P, et al., A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene. 2001 May 3;20(20):2544-50
• All: 4 reference(s)