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Aldh2
Gene Detail
Symbol

Name
ID
Aldh2
aldehyde dehydrogenase 2, mitochondrial
MGI:99600
Synonyms
Ahd5, Ahd-5
Feature Type
protein coding gene
Genetic Map
Chromosome 5
61.86 cM, cytoband F-G1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:121566027-121593824 bp, - strand
From VEGA annotation of GRCm38

  27798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: ALDH2
Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh2

Human
homologs
ALDH2, aldehyde dehydrogenase 2 family (mitochondrial)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 217
neXtProt AC: NX_P05091

Human Synonyms: ALDH-E2, ALDHI, ALDM

Human Chr (Location): 12q24.2; chr12:111766887-111809985 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ALDH2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(21) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in the absence of oxidation activity in the mitochondria. Mice homozygous for a different allele exhibit decreased litter size.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Aldh2 interacts with 257 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (99)    Tissues (99)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 5
cDNA source data(610)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aldh2 ; ZFIN aldh2.1, aldh2.2    NEW 
Molecular
reagents
All nucleic(617) Genomic(4) cDNA(611) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023440 (Evidence)
Ensembl Gene Model ENSMUSG00000029455 (Evidence)
Entrez Gene 11669 (Evidence)
UniGene 284446
DFCI TC1573832, TC1651156, TC1662565
DoTS DT.101370230, DT.101400567, DT.55210725, DT.60118257, DT.94175619
NIA Mouse Gene Index U026686
EC 1.2.1.3
Consensus CDS Project CCDS19638.1
International Mouse Phenotyping Consortium Status Aldh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023440 VEGA Gene Model | MGI Sequence Detail 27798 C57BL/6J ±  kb
transcript OTTMUST00000056973 VEGA | MGI Sequence Detail 3867 Not Applicable 
polypeptide OTTMUSP00000027439 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(233 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003925 aldehyde dehydrogenase, mitochondrial
References
(Earliest) J:32774 Algar EM, et al., Aldehyde Dehydrogenase (Ahd). Mouse News Lett. 1985;72:101-102
(Latest) J:215904 Zambelli VO, et al., Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. Sci Transl Med. 2014 Aug 27;6(251):251ra118
All references(74)
Other
accession IDs
MGD-MRK-1210, MGD-MRK-1217, MGD-MRK-16382

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory