Aldh2
Gene Detail

Symbol Name ID

Aldh2 aldehyde dehydrogenase 2, mitochondrial MGI:99600

Synonyms

Ahd5, Ahd-5

Feature Type

protein coding gene

Genetic Map

Chromosome 5

61.86 cM, cytoband F-G1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:121566027-121593824 bp, - strand From VEGA annotation of GRCm38   27798 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh2

Human homologs

Human Homolog		ALDH2, aldehyde dehydrogenase 2 family (mitochondrial)
NCBI Gene ID		217
neXtProt AC		NX_P05091
Human Synonyms		ALDH-E2, ALDHI, ALDM
Human Chr (Location)		12q24.2; chr12:112204691-112247789 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ALDH2

Alleles and phenotypes

All alleles(24) : Targeted(3) Gene trapped(21)
 

Homozygous mutation of this gene results in the absence of oxidation activity in the mitochondria. Mice homozygous for a different allele exhibit decreased litter size.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	metabolic process, negative regulation of apoptotic process
Component	mitochondrion
Function	aldehyde dehydrogenase (NAD) activity, identical protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (102)    Tissues (102)    Images (14)
Theiler Stages: 1, 3, 4, 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	8

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(4) cDNA(23) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023440 (Evidence)
Ensembl Gene Model	ENSMUSG00000029455 (Evidence)
Entrez Gene	11669 (Evidence)
DFCI	TC1573832, TC1651156, TC1662565
DoTS	DT.101370230, DT.101400567, DT.55210725, DT.60118257, DT.94175619
NIA Mouse Gene Index	U026686
EC	1.2.1.3
Consensus CDS Project	CCDS19638.1
International Mouse Knockout Project Status	Aldh2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023440	VEGA Gene Model | MGI Sequence Detail	27798	C57BL/6J
transcript	OTTMUST00000056973	VEGA | MGI Sequence Detail	3867	Not Applicable
polypeptide	OTTMUSP00000027439	VEGA | MGI Sequence Detail	519	Not Applicable

All sequences(74) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(220 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016160	Aldehyde dehydrogenase, conserved site
InterPro	IPR016163	Aldehyde dehydrogenase, C-terminal
InterPro	IPR015590	Aldehyde dehydrogenase domain
InterPro	IPR016162	Aldehyde dehydrogenase, N-terminal
InterPro	IPR016161	Aldehyde/histidinol dehydrogenase
Protein Ontology	PR:000003925	aldehyde dehydrogenase, mitochondrial

References

(Earliest) J:32774 Algar EM, et al., Aldehyde Dehydrogenase (Ahd). Mouse News Lett. 1985;72:101-102
(Latest) J:193832 Tsuchiya T, et al., Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice. Bone. 2013 Apr;53(2):358-68
All references(66)

Other accession IDs

MGD-MRK-1210, MGD-MRK-1217, MGD-MRK-16382