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Aldh2
Gene Detail
Symbol

Name
ID
Aldh2
aldehyde dehydrogenase 2, mitochondrial
MGI:99600
Synonyms
Ahd5, Ahd-5
Feature Type
protein coding gene
Genetic Map
Chromosome 5
61.86 cM, cytoband F-G1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:121566027-121593824 bp, - strand
From VEGA annotation of GRCm38

  27798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh2

Human
homologs
Human Homolog ALDH2, aldehyde dehydrogenase 2 family (mitochondrial)
NCBI Gene ID 217
neXtProt AC  NX_P05091
Human Synonyms  ALDH-E2, ALDHI, ALDM
Human Chr (Location)  12q24.2; chr12:111766887-111809985 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ALDH2
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(21) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in the absence of oxidation activity in the mitochondria. Mice homozygous for a different allele exhibit decreased litter size.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Aldh2 interacts with 258 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (99)    Tissues (99)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 5
cDNA source data(610)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(617) Genomic(4) cDNA(611) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023440 (Evidence)
Ensembl Gene ModelENSMUSG00000029455 (Evidence)
Entrez Gene11669 (Evidence)
UniGene284446
DFCITC1573832, TC1651156, TC1662565
DoTSDT.101370230, DT.101400567, DT.55210725, DT.60118257, DT.94175619
NIA Mouse Gene IndexU026686
EC1.2.1.3
Consensus CDS ProjectCCDS19638.1
International Mouse Knockout Project StatusAldh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023440 VEGA Gene Model | MGI Sequence Detail 27798 C57BL/6J ±  kb
transcript OTTMUST00000056973 VEGA | MGI Sequence Detail 3867 Not Applicable 
polypeptide OTTMUSP00000027439 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(2) UniProt(13)
Polymorphisms
SNPs within 2kb(233 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003925 aldehyde dehydrogenase, mitochondrial
References
(Earliest) J:32774 Algar EM, et al., Aldehyde Dehydrogenase (Ahd). Mouse News Lett. 1985;72:101-102
(Latest) J:200778 Goldstein DS, et al., Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease. J Neurochem. 2013 Sep;126(5):591-603
All references(74)
Other
accession IDs
MGD-MRK-1210, MGD-MRK-1217, MGD-MRK-16382

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory