Symbol
Name
ID

Aldh2
aldehyde dehydrogenase 2, mitochondrial
MGI:99600

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Decreased level of 1,5 anhydroglucitol in serum	Elevated circulating hepatic transaminase concentration	Hyperglycemia	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance	Ketoacidosis	Hepatic steatosis
Disease(s) Associated with ALDH2	Decreased level of 1,5 anhydroglucitol in serum	Elevated circulating hepatic transaminase concentration	Hyperglycemia	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance	Ketoacidosis	Hepatic steatosis
metabolic dysfunction-associated steatotic liver disease
pancreatic cancer
type 1 diabetes mellitus
type 2 diabetes mellitus

Mouse Phenotypes

impaired exercise endurance

decreased mitochondria enzyme/coenzyme activity

abnormal circulating hormone level

decreased circulating HDL cholesterol level

decreased circulating LDL cholesterol level

decreased circulating cholesterol level

increased circulating free fatty acids level

decreased circulating alkaline phosphatase level

decreased circulating total protein level

increased circulating enzyme/coenzyme activity

decreased liver enzyme/coenzyme activity

abnormal ethanol metabolism

increased incidence of tumors by chemical induction

Availability

Mouse Genotype

Aldh2^tm1.1Mak/Aldh2^tm1.1Mak

Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi}

Aldh2^tm1Kaw/Aldh2^tm1Kaw

Aldh2^tm1.1Mak/Aldh2⁺

Aldh2^tm1Dmro/Aldh2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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