Phenotypes Associated with This Genotype

Genotype
MGI:5699096

• Allelic Composition: Tg(APPSWE)2576Kha/?; Tg(EIF1AX-Aldh2*E487K)101Oht/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:219346 )

• mutants begin dying by 120 days of age and death rate accelerates after 240 days compared to either single mutant

growth/size/body

decreased body weight ( J:219346 )

• mutants weigh less than wild-type mice and single Tg(EIF1AX-Aldh2*E487K)101Oht mice, but exhibit no weight differences from single Tg(APPSWE)2576Kha mice

behavior/neurological

abnormal object recognition memory ( J:219346 )

• in the object recognition test, exploratory preference for the novel object is lower at 3 months of age compared to wild-type mice or either single mutant, and is lower at 6 months of age compared to wild-type mice or single Tg(EIF1AX-Aldh2*E487K)101Oht mice

abnormal spatial working memory ( J:219346 )

• at 3 and 6 months of age, the alternation rate of Y-maze is lower than in wild-type mice or either single mutant

homeostasis/metabolism

amyloid beta deposits ( J:219346 )

• amyloid beta plaques are detected in the brain at 6 months of age, a time when plaques are not seen in single Tg(APPSWE)2576Kha mice

• at 12-15 months of age, more amyloid beta40 and amyloid beta42 plaques are seen than in single Tg(APPSWE)2576Kha mice

nervous system

amyloid beta deposits ( J:219346 )

• amyloid beta plaques are detected in the brain at 6 months of age, a time when plaques are not seen in single Tg(APPSWE)2576Kha mice

• at 12-15 months of age, more amyloid beta40 and amyloid beta42 plaques are seen than in single Tg(APPSWE)2576Kha mice

tau protein deposits ( J:219346 )

• deposition of phosphorylated tau proteins in the brains is increased at 9 months of age compared to single Tg(APPSWE)2576Kha mice

astrocytosis ( J:219346 )

• mutants show a greater number of astrocyte clusters in the CA1 region of the hippocampus and cerebral cortex at 6, 9, and 12 months of age than single Tg(APPSWE)2576Kha mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:219346