About   Help   FAQ
Wt1
Gene Detail
Symbol

Name
ID
Wt1
Wilms tumor 1 homolog
MGI:98968
Synonyms
D630046I19Rik, Wt-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
55.06 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:105126529-105173616 bp, + strand
From VEGA annotation of GRCm38

  47088 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WT1
Gene Tree: Wt1

Human
homologs
WT1, Wilms tumor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7490
neXtProt AC: NX_P19544

Human Synonyms: AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33

Human Chr (Location): 11p13; chr11:32387775-32435535 (-)  GRCh38.p2

Disease Associations: (8) Diseases Associated with Human WT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(18)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Mutants have abnormalities of the heart, mesothelium and lungs and die between embryonic day 13.5 and birth.
 
Human Diseases Modeled in Mice Using Wt1 (1)    Mutations Annotated to Human Diseases (5)   
Interactions
Wt1 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (105 annotations)
Process adrenal cortex formation, adrenal gland development, ...
Component cytoplasm, nuclear speck, ...
Function C2H2 zinc finger domain binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (297 records)
Data Summary: Results (1196)    Tissues (649)    Images (208)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 235
RNA in situ 724
In situ reporter (knock in) 10
Northern blot 27
Western blot 6
RT-PCR 194
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wt1 ; ZFIN wt1a, wt1b    NEW 
Molecular
reagents
All nucleic(57) Genomic(12) cDNA(30) Primer pair(14) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014987 (Evidence)
Ensembl Gene Model ENSMUSG00000016458 (Evidence)
Entrez Gene 22431 (Evidence)
UniGene 389339
DFCI TC1582846, TC1622031
DoTS DT.489369, DT.91302017, DT.94264560
NIA Mouse Gene Index U002201
Consensus CDS Project CCDS16496.2
International Mouse Phenotyping Consortium Status Wt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014987 VEGA Gene Model | MGI Sequence Detail 47088 C57BL/6J ±  kb
transcript OTTMUST00000035573 VEGA | MGI Sequence Detail 3090 Not Applicable 
polypeptide OTTMUSP00000015944 VEGA | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(9)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(365 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017987 Wilm's tumour protein
InterPro IPR000976 Wilm's tumour protein, N-terminal
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017459 Wilms tumor protein
References
(Earliest) J:10820 Glaser T, et al., A mouse model of the aniridia-Wilms tumor deletion syndrome. Science. 1990 Nov 9;250(4982):823-7
(Latest) J:220996 La Sala G, et al., Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015 May;29(5):2059-69
All references(426)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-15464, MGD-MRK-15465, MGI:2441985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory