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Wt1 Gene Detail
Summary
  • Symbol
    Wt1
  • Name
    Wilms tumor 1 homolog
  • Synonyms
    D630046I19Rik, Wt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98968
    NCBI Gene: 22431
  • Gene Overview
    MyGene.info: WT1
Location & Maps
more
  • Sequence Map
    Chr2:105126529-105173616 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47088 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 55.06 cM, cytoband E
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    WT1, Wilms tumor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WT1, Wilms tumor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
  • Links
    NCBI Gene ID: 7490
    neXtProt AC: NX_P19544

  • Chr Location
    11p13; chr11:32387775-32435535 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11536
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: WT1
  • Gene Tree
    Wt1
Human Diseases
more
  • Diseases
    1 with Wt1 mouse models; 8 with human WT1 associations

Human Disease Mouse Models
       Denys-Drash Syndrome; DDS   OMIM: 194080 View 6 models
       Aniridia; AN   OMIM: 106210
Frasier Syndrome   OMIM: 136680
Meacham Syndrome   OMIM: 608978
Mesothelioma, Malignant; MESOM   OMIM: 156240
Nephrotic Syndrome, Type 4; NPHS4   OMIM: 256370
Wilms Tumor 1; WT1   OMIM: 194070 View 1 model
Wilms Tumor, Aniridia, Genitourinary Anomalies, and Mental Retardation Syndrome; WAGR   OMIM: 194072
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    84 phenotypes from 15 alleles in 20 genetic backgrounds
    48 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    20
  • Transgenic
    3
  • Genomic Mutations
    2 involving Wt1
  • Incidental Mutations
Homozygous mutants fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Mutants have abnormalities of the heart, mesothelium and lungs and die between embryonic day 13.5 and birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014987 VEGA Gene Model | MGI Sequence Detail 47088 C57BL/6J ±  kb
transcript OTTMUST00000035573 VEGA | MGI Sequence Detail 3090 Not Applicable  
polypeptide OTTMUSP00000015944 VEGA | MGI Sequence Detail 517 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    365 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 57
    Genomic 12
    cDNA 30
    Primer pair 14
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15464, MGD-MRK-15465, MGI:2441985
References
more
  • Summaries
    All 456
    Developmental Gene Expression 326
    Diseases 6
    Gene Ontology 34
    Phenotypes 114
  • Earliest
    J:10820 Glaser T, et al., A mouse model of the aniridia-Wilms tumor deletion syndrome. Science. 1990 Nov 9;250(4982):823-7
  • Latest
    J:232556 Bao J, et al., UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory