About   Help   FAQ
Wt1 Gene Detail
Summary
  • Symbol
    Wt1
  • Name
    WT1 transcription factor
  • Synonyms
    D630046I19Rik, Wilms tumor 1 homolog, Wt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98968
    NCBI Gene: 22431
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:104956874-105003959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 55.06 cM, cytoband E
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1361 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98968
 protein coding gene Chr2:104956874-105003961 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026227
 protein coding gene Chr2:107277345-107325495 (+)
A/J MGP_AJ_G0026188
 protein coding gene Chr2:102794239-102842511 (+)
AKR/J MGP_AKRJ_G0026168
 protein coding gene Chr2:105600291-105649769 (+)
BALB/cJ MGP_BALBcJ_G0026197
 protein coding gene Chr2:103073942-103124538 (+)
C3H/HeJ MGP_C3HHeJ_G0025947
 protein coding gene Chr2:105916462-105967847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026648
 protein coding gene Chr2:110807729-110858704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024034
 protein coding gene Chr2:98593727-98641533 (+)
CAST/EiJ MGP_CASTEiJ_G0025412
 protein coding gene Chr2:106431640-106499989 (+)
CBA/J MGP_CBAJ_G0025925
 protein coding gene Chr2:114604930-114667162 (+)
DBA/2J MGP_DBA2J_G0026063
 protein coding gene Chr2:102338385-102386493 (+)
FVB/NJ MGP_FVBNJ_G0026026
 protein coding gene Chr2:101321123-101369084 (+)
LP/J MGP_LPJ_G0026166
 protein coding gene Chr2:107387334-107437467 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026050
 protein coding gene Chr2:118473369-118522999 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026702
 protein coding gene Chr2:105791467-105841148 (+)
PWK/PhJ MGP_PWKPhJ_G0025147
 protein coding gene Chr2:101880350-101944790 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024947
 protein coding gene Chr2:105014090-105089275 (+)
WSB/EiJ MGP_WSBEiJ_G0025479
 protein coding gene Chr2:106527394-106579566 (+)



Homology
more
  • Human Ortholog
    WT1, WT1 transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WT1, WT1 transcription factor
  • Synonyms
    AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33
  • Links
    NCBI Gene ID: 7490
    UniProt: P19544

  • Chr Location
    11p13; chr11:32387775-32435564 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Wt1 mouse models; 7 with human WT1 associations

Human Disease Mouse Models
      
IDs
 View 6 models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 15 alleles in 22 genetic backgrounds
    24 phenotypes from multigenic genotypes
    250 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Heart, mesothelium and lung anomalies and variable lethality are observed. Females heterozygous for a point mutation are subfertile with small ovaries and impaired ovarian folliculogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    145
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2564
  • Tissues
    782
  • cDNA Data
    33
  • Literature Summary
    558
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22431 NCBI Gene Model | MGI Sequence Detail 47086 C57BL/6J ±  kb
    transcript NM_144783 RefSeq | MGI Sequence Detail 3092 ZRU/MplStud  
    polypeptide P22561 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      Genomic 12
      cDNA 35
      Primer pair 27
      Other 22

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15464, MGD-MRK-15465, MGI:2441985
    References
    more
    • Summaries
      All 811
      Developmental Gene Expression 558
      Diseases 8
      Gene Ontology 41
      Phenotypes 250
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:374433 Ediga HH, et al., Wilms tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions. J Clin Invest. 2025 Aug 1;135(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory