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Wt1
Gene Detail
 Symbol
Name
ID
Wt1
Wilms tumor 1 homolog
MGI:98968
Synonyms D630046I19Rik, Wt-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
55.06 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:105126529-105173616 bp, + strand
From VEGA annotation of GRCm38

  47088 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Wt1

Human
homologs
Human Homolog WT1, Wilms tumor 1
NCBI Gene ID 7490
neXtProt AC  NX_P19544
Human Synonyms  AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Human Chr (Location)  11p13; chr11:32387775-32435535 (-)  GRCh38
Disease Associations  (8) Diseases Associated with Human WT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Mutants have abnormalities of the heart, mesothelium and lungs and die between embryonic day 13.5 and birth.
 
Human Diseases Modeled Using Mouse Wt1 (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Wt1 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (98 annotations)
Process adrenal cortex formation, adrenal gland development, ...
Component cytoplasm, nuclear speck, ...
Function C2H2 zinc finger domain binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (271 records)
Data Summary: Results (1070)    Tissues (570)    Images (188)
Theiler Stages: 2, 3, 4, 5, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 208
RNA in situ 647
In situ reporter (knock in) 10
Northern blot 27
Western blot 6
RT-PCR 172
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(12) cDNA(29) Primer pair(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014987 (Evidence)
Ensembl Gene ModelENSMUSG00000016458 (Evidence)
Entrez Gene22431 (Evidence)
UniGene389339
DFCITC1582846, TC1622031
DoTSDT.489369, DT.91302017, DT.94264560
NIA Mouse Gene IndexU002201
Consensus CDS ProjectCCDS16496.2
International Mouse Knockout Project StatusWt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014987 VEGA Gene Model | MGI Sequence Detail 47088 C57BL/6J ±  kb
transcript OTTMUST00000035573 VEGA | MGI Sequence Detail 3090 Not Applicable 
polypeptide OTTMUSP00000015944 VEGA | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(9)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(365 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017987 Wilm's tumour protein
InterPro IPR000976 Wilm's tumour protein, N-terminal
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017459 Wilms tumor protein
References (Earliest) J:10820 Glaser T, et al., A mouse model of the aniridia-Wilms tumor deletion syndrome. Science. 1990 Nov 9;250(4982):823-7
(Latest) J:210334 Chen M, et al., Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice. Biol Reprod. 2014 Apr;90(4):71
All references(404)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-15464, MGD-MRK-15465, MGI:2441985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory