Wt1
Gene Detail

Symbol Name ID

Wt1 Wilms tumor 1 homolog MGI:98968

Synonyms

D630046I19Rik, Wt-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

55.06 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr2:105126529-105173616 bp, + strand From VEGA annotation of GRCm38   47088 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Wt1

Human homologs

Human Homolog		WT1, Wilms tumor 1
NCBI Gene ID		7490
neXtProt AC		NX_P19544
Human Synonyms		AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Human Chr (Location)		11p13; chr11:32409321-32457081 (-)  GRCh37.p10
Disease Associations		(8) Diseases Associated with Human WT1

Alleles and phenotypes

All alleles(17) : Targeted(17)
 

Homozygous mutants fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Mutants have abnormalities of the heart, mesothelium and lungs and die between embryonic day 13.5 and birth.

 
Human Diseases Modeled Using Mouse Wt1 (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (92 annotations)

Process	adrenal cortex formation, adrenal gland development, ...
Component	cytoplasm, nuclear speck, ...
Function	C2H2 zinc finger domain binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (249 records)
Data Summary: Results (715)    Tissues (378)    Images (144)
Theiler Stages: 2, 3, 4, 5, 6, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	168
RNA in situ	337
Northern blot	27
Western blot	4
RT-PCR	179

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(12) cDNA(27) Primer pair(10) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014987 (Evidence)
Ensembl Gene Model	ENSMUSG00000016458 (Evidence)
Entrez Gene	22431 (Evidence)
UniGene	389339
DFCI	TC1582846, TC1622031
DoTS	DT.489369, DT.91302017, DT.94264560
NIA Mouse Gene Index	U002201
Consensus CDS Project	CCDS16496.2
International Mouse Knockout Project Status	Wt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014987	VEGA Gene Model | MGI Sequence Detail	47088	C57BL/6J
transcript	OTTMUST00000035573	VEGA | MGI Sequence Detail	3090	Not Applicable
polypeptide	OTTMUSP00000015944	VEGA | MGI Sequence Detail	517	Not Applicable

All sequences(54) RefSeq(2) UniProt(8)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(274 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017987	Wilm's tumour protein
InterPro	IPR000976	Wilm's tumour protein, N-terminal
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017459	Wilms tumor protein

References

(Earliest) J:10820 Glaser T, et al., A mouse model of the aniridia-Wilms tumor deletion syndrome. Science. 1990 Nov 9;250(4982):823-7
(Latest) J:194489 Chen SR, et al., The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2. Biol Reprod. 2013;88(3):56
All references(367)

Other accession IDs

MGD-MRK-15464, MGD-MRK-15465, MGI:2441985