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Wt1 Gene Detail
Summary
  • Symbol
    Wt1
  • Name
    Wilms tumor 1 homolog
  • Synonyms
    D630046I19Rik, Wt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98968
    NCBI Gene: 22431
  • Gene Overview
    MyGene.info: WT1
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:105126529-105173614 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 55.06 cM, cytoband E
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98968
protein coding gene Chr2:105126529-105173616 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026227
protein coding gene Chr2:107277345-107325495 (+)
A/J MGP_AJ_G0026188
protein coding gene Chr2:102794239-102842511 (+)
AKR/J MGP_AKRJ_G0026168
protein coding gene Chr2:105600291-105649769 (+)
BALB/cJ MGP_BALBcJ_G0026197
protein coding gene Chr2:103073942-103124538 (+)
C3H/HeJ MGP_C3HHeJ_G0025947
protein coding gene Chr2:105916462-105967847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026648
protein coding gene Chr2:110807729-110858704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024034
protein coding gene Chr2:98593727-98641533 (+)
CAST/EiJ MGP_CASTEiJ_G0025412
protein coding gene Chr2:106431640-106499989 (+)
CBA/J MGP_CBAJ_G0025925
protein coding gene Chr2:114604930-114667162 (+)
DBA/2J MGP_DBA2J_G0026063
protein coding gene Chr2:102338385-102386493 (+)
FVB/NJ MGP_FVBNJ_G0026026
protein coding gene Chr2:101321123-101369084 (+)
LP/J MGP_LPJ_G0026166
protein coding gene Chr2:107387334-107437467 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026050
protein coding gene Chr2:118473369-118522999 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026702
protein coding gene Chr2:105791467-105841148 (+)
PWK/PhJ MGP_PWKPhJ_G0025147
protein coding gene Chr2:101880350-101944790 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024947
protein coding gene Chr2:105014090-105089275 (+)
WSB/EiJ MGP_WSBEiJ_G0025479
protein coding gene Chr2:106527394-106579566 (+)



Homology
more
  • Human Ortholog
    WT1, Wilms tumor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WT1, Wilms tumor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AWT1, GUD, NPHS4, WAGR, WIT-2, WT33
  • Links
    NCBI Gene ID: 7490
    neXtProt AC: NX_P19544
    UniProt: P19544

  • Chr Location
    11p13; chr11:32387775-32435535 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11536
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WT1
  • Gene Tree
    Wt1
Human Diseases
more
  • Diseases
    2 with Wt1 mouse models; 6 with human WT1 associations

Human Disease Mouse Models
      
IDs
View 6 models
      
IDs
View 2 models
      
IDs
IDs
IDs
IDs
View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    91 phenotypes from 15 alleles in 22 genetic backgrounds
    48 phenotypes from multigenic genotypes
    154 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Mutants have abnormalities of the heart, mesothelium and lungs and die between embryonic day 13.5 and birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22431 NCBI Gene Model | MGI Sequence Detail 47086 C57BL/6J ±  kb
    transcript NM_144783 RefSeq | MGI Sequence Detail 3092 C57BL/6  
    polypeptide P22561 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 12
      cDNA 32
      Primer pair 16
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15464, MGD-MRK-15465, MGI:2441985
    References
    more
    • Summaries
      All 564
      Developmental Gene Expression 381
      Diseases 8
      Gene Ontology 36
      Phenotypes 154
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:266086 Tsukiji N, et al., Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction. Blood. 2018 Sep 13;132(11):1167-1179

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory