Wt1^tm1.1Lahe
Targeted Allele Detail

Summary

• Symbol: Wt1^tm1.1Lahe
• Name: WT1 transcription factor; targeted mutation 1.1, Laurence Heidet
• MGI ID: MGI:4413579
• Synonyms: Wt1^mut
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^tm1.1Lahe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154995
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Mutations were introduced at c.C1180T and c.C1179A. The latter is silent while the former produces an amino acid substitution of tryphtophan for arginine at position 394 (R394W). A floxed neo cassette inserted downstream of the modified exon 9 was removed by cre mediated recombination. (J:154995)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:154995 Ratelade J, et al., A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes. Hum Mol Genet. 2010 Jan 1;19(1):1-15
• All: 1 reference(s)