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Wt1tm1Jae
Targeted Allele Detail
Summary
Symbol: Wt1tm1Jae
Name: WT1 transcription factor; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1857268
Synonyms: wt1-
Gene: Wt1  Location: Chr2:104956874-105003959 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Alliance: Wt1tm1Jae page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:14317
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 1 and 0.5kb of upstream sequence were replaced with a neomycin selection cassette. (J:14317)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 275 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 13 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Wt1tm1Jae
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:  34 strains or lines available
References
Original:  J:14317 Kreidberg JA, et al., WT-1 is required for early kidney development. Cell. 1993 Aug 27;74(4):679-91
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory