Wt1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wt1
WT1 transcription factor
MGI:98968

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal kidney mesenchyme morphology	J:211179
	delayed kidney development	J:211179
	increased kidney tumor incidence	J:211179
	kidney cyst	J:211179
Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	small kidney	J:211179
Dis3l2^em2Jtm/Dis3l2^em2Jtm Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺ involves: 129S4/SvJae * C57BL/6J	normal renal/urinary system phenotype	J:272435
Drosha^tm1Litt/Drosha^tm1Litt Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ involves: 129P2/OlaHsd * 129S4/SvJae	increased urine protein level	J:321428
	normal mortality/aging	J:321428
	normal neoplasm	J:321428
	normal renal/urinary system phenotype	J:321428
Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺ Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺ Zfpm2^tm1Sho/Zfpm2^tm1Sho involves: 129S1/Sv * 129S4/SvJaeSor	normal cardiovascular system phenotype	J:150452
Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺ Wt1^tm1Jae/Wt1^tm1Jae involves: 129S4/SvJae	abnormal epicardium development	J:147421
Pax2^1Neu/Pax2⁺ Wt1^tm1Jae/Wt1⁺ involves: 102 * 129S4/SvJae * C57BL/6	abnormal kidney calyx morphology	J:86661
	abnormal kidney collecting duct morphology	J:86661
	abnormal kidney development	J:86661
	absent kidney	J:86661
	decreased nephron number	J:86661
	decreased renal glomerulus number	J:86661
	increased kidney apoptosis	J:86661
	kidney medulla hypoplasia	J:86661
	lethality throughout fetal growth and development, incomplete penetrance	J:86661
	postnatal lethality, incomplete penetrance	J:86661
	small kidney	J:86661
Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺ Zfpm2^tm1Sho/Zfpm2^tm2Sho involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd	abnormal atrioventricular cushion morphology	J:150452
	normal cardiovascular system phenotype	J:150452
	perinatal lethality, complete penetrance	J:150452
	thin myocardium compact layer	J:150452

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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