Wt1^tm1.1Ndha
Targeted Allele Detail

Summary

• Symbol: Wt1^tm1.1Ndha
• Name: WT1 transcription factor; targeted mutation 1.1, Nicholas D Hastie
• MGI ID: MGI:4849364
• Synonyms: Wt1^co, Wt1^loxP
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^tm1.1Ndha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166573
• Parent Cell Line: E14TG2aIV (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:166573)

Disease models

Expression

In Mice Carrying this Mutation:	24 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:166573 Martinez-Estrada OM, et al., Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat Genet. 2010 Jan;42(1):89-93
• All: 15 reference(s)