About   Help   FAQ
Tcra Complex/Cluster/Region Detail
Summary
  • Symbol
    Tcra
  • Name
    T cell receptor alpha chain
  • Synonyms
    Tcralpha, Tcr alpha
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:98553
    NCBI Gene: 21473
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 14, cytoband D1-D2
  • Mapping Data
    51 experiments
  • Sequence Tag for
Strain
Comparison
more
  • PCR
  • RFLP
Human Diseases
more
  • Diseases
    2 with Tcra mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 13 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    14 with disease annotations
  • References
    18 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 11 alleles in 19 genetic backgrounds
    274 phenotypes from multigenic genotypes
    2 images
    5414 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display thymic hypoplasia and aberrant alphabeta T cell development. Inflammatory bowel disease develops as these mice age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Other Mouse Links
    Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    transcript U07662 GenBank | ENA | DDBJ | MGI Sequence Detail 1420 SJL-7A5*  
    polypeptide P01849 UniProt | EBI | MGI Sequence Detail 138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 2
      Primer pair 4
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14845
    References
    more
    • Summaries
      All 5619
      Developmental Gene Expression 6
      Diseases 18
      Gene Ontology 5
      Phenotypes 5414
    • Earliest
      J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
    • Latest
      J:330635 Zhong X, et al., Decoupling the role of RORgammat in the differentiation and effector function of TH17 cells. Sci Adv. 2022 Oct 21;8(42):eadc9221

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Copyright, and Privacy Statement
    Send questions and comments to User Support.
    last database update
    11/22/2022
    MGI 6.22
    The Jackson Laboratory