Tcra
Complex/Cluster/Region Detail

Symbol Name ID

Tcra T cell receptor alpha chain MGI:98553

STS for

D14Nds4

Synonyms

Tcralpha, Tcr alpha

Feature Type

complex/cluster/region

Genetic Map

Chromosome 14
cytoband D1-D2

Mapping data(51)

Vertebrate homology

Protein SuperFamily: T-cell receptor, alpha chain C region

Alleles and phenotypes

All alleles(12) : Targeted(9) Other(3)
 

Homozygous null mice display thymic hypoplasia and aberrant alphabeta T cell development. Inflammatory bowel disease develops as these mice age.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	protein homotetramerization, T cell lineage commitment
Component	alpha-beta T cell receptor complex, cell surface, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (41)    Tissues (20)   
Theiler Stages: 16, 18, 20, 21, 22, 23, 28

Assay Type	Results
Northern blot	12
RT-PCR	29

cDNA source data(2)
External Resources: GEO  

Molecular reagents

All nucleic(8) cDNA(2) Primer pair(3) Other(3)
Microarray probesets(3)

Other database links

Entrez Gene	21473 (Evidence)
DFCI	TC1593110, TC1610156
DoTS	DT.97370151
PDB	2J8U, 2JCC, 3C6L, 3MBE, 2Q86

Sequences

Length	Strain/Species
transcript	U07662	GenBank | EMBL | DDBJ | MGI Sequence Detail	1420	SJL-7A5*
polypeptide	P01849	UniProt | EBI | MGI Sequence Detail	138	Not Applicable

All sequences(7) RefSeq(1) UniProt(1)

Polymorphisms

All PCR and RFLP(10) : PCR(4) RFLP(6) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015370	Domain of unknown function DUF1968
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000035226	T-cell receptor alpha chain C region

Graphical View of Protein Domain Structure

References

(Earliest) J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
(Latest) J:194909 Hirota K, et al., Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol. 2013 Apr;14(4):372-9
All references(476)

Other accession IDs

MGD-MRK-14845