Phenotypes for H2 Rag1 Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse MGI:3687164 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2^g7/H2^g7 Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^g7 mutation (24 available); any H2 mutation (280 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

insulitis ( J:111874 )

• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

immune system

insulitis ( J:111874 )

• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

increased susceptibility to autoimmune diabetes ( J:111874 )

• 15% of mice heterozygous for H2^g7 develop diabetes, compared to 50% of homozygous mice or 0% of non-H2^g7 mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:111874

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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