About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3625063
Allelic
Composition		 Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background		 NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1Cgn mutation (4 available); any Il4 mutation (41 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:85924 )
• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice

immune system
insulitis ( J:85924 )
• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice
decreased susceptibility to autoimmune diabetes ( J:85924 )
• Il4-deficient transgenic NOD mice do not show early or frequent diabetes compared to control transgenic NOD mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:85924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory