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Pdgfrb
Gene Detail
 Symbol
Name
ID
Pdgfrb
platelet derived growth factor receptor, beta polypeptide
MGI:97531
Synonyms CD140b, Pdgfr
Feature Type protein coding gene
Genetic Map
Chromosome 18
34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr18:61045150-61085061 bp, + strand
From VEGA annotation of GRCm38

  39912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Pdgfrb

Human
homologs
Human Homolog PDGFRB, platelet-derived growth factor receptor, beta polypeptide
NCBI Gene ID 5159
neXtProt AC  NX_P09619
Human Synonyms  CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR1, PDGFR-1
Human Chr (Location)  5q33.1; chr5:150113839-150155884 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PDGFRB
Alleles
and
phenotypes
All alleles(25) : Targeted(23) Gene trapped(2)
 
Homozygous null mutants die perinatally with internal bleeding, thrombocytopenia, anemia and kidney defects. A frameshift mutation results in neonatal lethals with edema and hemorrhaging; several point mutations show cardiovascular abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (107 annotations)
Process adrenal gland development, aorta morphogenesis, ...
Component apical plasma membrane, cell surface, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (105 records)
Data Summary: Results (176)    Tissues (149)    Images (34)
Theiler Stages: 9, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 19
RNA in situ 126
Western blot 15
RNase protection 16
cDNA source data(115)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(121) Genomic(1) cDNA(116) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014920 (Evidence)
Ensembl Gene ModelENSMUSG00000024620 (Evidence)
Entrez Gene18596 (Evidence)
UniGene4146
DFCITC1575168
DoTSDT.532534, DT.99852478
NIA Mouse Gene IndexU018787
EC2.7.10.1
PDB1AYA, 1AYC
Consensus CDS ProjectCCDS50300.1
International Mouse Knockout Project StatusPdgfrb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014920 VEGA Gene Model | MGI Sequence Detail 39912 C57BL/6J ±  kb
transcript OTTMUST00000035439 VEGA | MGI Sequence Detail 5423 Not Applicable 
polypeptide OTTMUSP00000015855 VEGA | MGI Sequence Detail 1103 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(10) UniProt(7)
Polymorphisms RFLP(5) : SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR027288 Platelet-derived growth factor receptor beta
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology PR:000002035 beta-type platelet-derived growth factor receptor
References (Earliest) J:8434 Yarden Y, et al., Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature. 1986 Sep 18-24;323(6085):226-32
(Latest) J:203143 Bryson JL, et al., Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus. PLoS One. 2013;8(6):e65196
All references(227)
Other
accession IDs
MGD-MRK-13214, MGD-MRK-13217, MGI:2147240

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory