Pdgfrb
Gene Detail

Symbol Name ID

Pdgfrb platelet derived growth factor receptor, beta polypeptide MGI:97531

Synonyms

CD140b, Pdgfr

Feature Type

protein coding gene

Genetic Map

Chromosome 18

34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr18:61045150-61085061 bp, + strand From VEGA annotation of GRCm38   39912 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Pdgfrb

Human homologs

Human Homolog		PDGFRB, platelet-derived growth factor receptor, beta polypeptide
NCBI Gene ID		5159
neXtProt AC		NX_P09619
Human Synonyms		CD140B, IBGC4, JTK12, PDGFR, PDGFR1, PDGFR-1
Human Chr (Location)		5q33.1; chr5:149493402-149535422 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PDGFRB

Alleles and phenotypes

All alleles(25) : Targeted(23) Gene trapped(2)
 

Homozygous null mutants die perinatally with internal bleeding, thrombocytopenia, anemia and kidney defects. A frameshift mutation results in neonatal lethals with edema and hemorrhaging; several point mutations show cardiovascular abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (105 annotations)

Process	adrenal gland development, aorta morphogenesis, ...
Component	apical plasma membrane, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (93 records)
Data Summary: Results (82)    Tissues (61)    Images (28)
Theiler Stages: 9, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	38
Western blot	15
RNase protection	16

cDNA source data(110)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(116) Genomic(1) cDNA(111) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014920 (Evidence)
Ensembl Gene Model	ENSMUSG00000024620 (Evidence)
Entrez Gene	18596 (Evidence)
UniGene	4146
DFCI	TC1575168
DoTS	DT.532534, DT.99852478
NIA Mouse Gene Index	U018787
EC	2.7.10.1
PDB	1AYA, 1AYC
Consensus CDS Project	CCDS50300.1
International Mouse Knockout Project Status	Pdgfrb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014920	VEGA Gene Model | MGI Sequence Detail	39912	C57BL/6J
transcript	OTTMUST00000035439	VEGA | MGI Sequence Detail	5423	Not Applicable
polypeptide	OTTMUSP00000015855	VEGA | MGI Sequence Detail	1103	Not Applicable

All sequences(38) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(5) : SNPs(201 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013151	Immunoglobulin
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016243	Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
InterPro	IPR009134	Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
Protein Ontology	PR:000002035	beta-type platelet-derived growth factor receptor

References

(Earliest) J:8434 Yarden Y, et al., Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature. 1986 Sep 18-24;323(6085):226-32
(Latest) J:194480 Ma S, et al., Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 2013 Jan;11(1):e1001469
All references(208)

Other accession IDs

MGD-MRK-13214, MGD-MRK-13217, MGI:2147240