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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdgfrb
platelet derived growth factor receptor, beta polypeptide
MGI:97531
92 phenotypes from 16 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
C57BL/6J-Pdgfrbb2b2903Clo 		abnormal left subclavian artery morphology J:175213
abnormal pulmonary artery morphology J:175213
atrioventricular septal defect J:175213
clinodactyly J:175213
double outlet right ventricle J:175213
micrognathia J:175213
muscular ventricular septal defect J:175213
overriding aortic valve J:175213
perimembraneous ventricular septal defect J:175213
petechiae J:175213
right aortic arch J:175213
short snout J:175213
thymus hypoplasia J:175213
vascular ring J:175213
ventricular septal defect J:175213
Pdgfrbredeye/Pdgfrbredeye
C3N.C-Pdgfrbredeye 		abnormal basement membrane morphology J:199483
abnormal blood-retina barrier function J:199483
abnormal pericyte morphology J:199483
abnormal retina blood vessel morphology J:199483
abnormal retina blood vessel pattern J:199483
abnormal retina vasculature morphology J:199483
decreased retina ganglion cell number J:199483
eye hemorrhage J:199483
normal homeostasis/metabolism phenotype J:199483
increased retina apoptosis J:199483
increased vascular permeability J:199483
normal renal/urinary system phenotype J:199483
retina ganglion cell degeneration J:199483
normal vision/eye phenotype J:199483
Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H 		abnormal seminal vesicle morphology J:211773
decreased circulating fructosamine level J:211773
enlarged heart J:211773
increased circulating triglyceride level J:211773
Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrbtm1b(EUCOMM)Hmgu
C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H 		preweaning lethality, complete penetrance J:211773
Pdgfrbtm1Mdt/Pdgfrbtm1Mdt
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6 * CBA 		perimembraneous ventricular septal defect J:122584
Pdgfrbtm1Msas/Pdgfrbtm1Msas
involves: 129 * C57BL/6 		decreased cell proliferation J:110798
impaired wound healing J:110798
increased apoptosis J:110798
Pdgfrbtm1Msas/Pdgfrbtm1Msas
Tg(Nes-cre)1Nogu/0
B6J.Cg-Pdgfrbtm1Msas Tg(Nes-cre)1Nogu 		abnormal nervous system electrophysiology J:229179
abnormal social investigation J:229179
decreased neuron number J:229179
decreased prepulse inhibition J:229179
reduced sensorimotor gating J:229179
Pdgfrbtm1Msas/Pdgfrbtm1Msas
Tg(Nes-cre)1Nogu/?
involves: 129 * C57BL/6 		abnormal response to injury J:110616
increased susceptibility to neuronal excitotoxicity J:110616
Pdgfrbtm1Rheu/Pdgfrbtm1Rheu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal embryonic hematopoiesis J:138069
abnormal fibroblast migration J:93973
decreased fibroblast apoptosis J:93973
Pdgfrbtm1Sor/Pdgfrbtm1Sor
either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J) 		abnormal erythrocyte morphology J:20016
abnormal venule morphology J:20016
absent mesangial cell J:20016
absent podocytes J:20016
anemia J:20016
anisocytosis J:20016
decreased glomerular capillary number J:20016
glomerulus hemorrhage J:20016
hemorrhage J:20016
hydrops fetalis J:20016
increased nucleated erythrocyte cell number J:20016
kidney hemorrhage J:20016
lethality throughout fetal growth and development, incomplete penetrance J:20016
pallor J:20016
perinatal lethality, incomplete penetrance J:20016
poikilocytosis J:20016
polychromatophilia J:20016
purpura J:20016
schistocytosis J:20016
thrombocytopenia J:20016
Pdgfrbtm1Sor/Pdgfrbtm1Sor
involves: 129S7/SvEvBrd 		abnormal angiogenesis J:138069
decreased angiogenesis J:138069
Pdgfrbtm1Sor/Pdgfrbtm1Sor
involves: 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:78912
abnormal pericyte morphology J:56682
abnormal placenta vasculature J:56682
abnormal placental labyrinth vasculature morphology J:56682
abnormal trophoblast layer morphology J:56682
abnormal vascular endothelial cell morphology J:78912
increased vascular endothelial cell number J:78912
Pdgfrbtm1Sor/Pdgfrbtm8Sor
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:86542
abnormal eye morphology J:86542
abnormal heart morphology J:86542
abnormal pericyte morphology J:86542
abnormal retina vasculature morphology J:86542
cardiac fibrosis J:86542
dilated heart atrium J:86542
eye hemorrhage J:86542
eye opacity J:86542
increased heart ventricle size J:86542
Pdgfrbtm1Sor/Pdgfrbtm9Sor
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:86542
abnormal eye morphology J:86542
abnormal heart morphology J:86542
abnormal pericyte morphology J:86542
abnormal retina vasculature morphology J:86542
cardiac fibrosis J:86542
dilated heart atrium J:86542
eye hemorrhage J:86542
eye opacity J:86542
increased heart ventricle size J:86542
Pdgfrbtm2Msas/Pdgfrbtm2Msas
Tg(Nes-cre)1Nogu/?
involves: 129 * C57BL/6 		abnormal response to injury J:110616
Pdgfrbtm2Sor/Pdgfrbtm2Sor
either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J) 		abnormal erythrocyte morphology J:20016
abnormal venule morphology J:20016
absent mesangial cell J:20016
absent podocytes J:20016
anemia J:20016
anisocytosis J:20016
decreased glomerular capillary number J:20016
glomerulus hemorrhage J:20016
hemorrhage J:20016
hydrops fetalis J:20016
increased nucleated erythrocyte cell number J:20016
kidney hemorrhage J:20016
lethality throughout fetal growth and development, incomplete penetrance J:20016
pallor J:20016
perinatal lethality, incomplete penetrance J:20016
poikilocytosis J:20016
polychromatophilia J:20016
purpura J:20016
schistocytosis J:20016
thrombocytopenia J:20016
Pdgfrbtm7Sor/Pdgfrbtm7Sor
involves: 129S4/SvJae * C57BL/6 		abnormal blood vessel morphology J:86542
abnormal pericyte morphology J:86542
Pdgfrbtm8Sor/Pdgfrbtm8Sor
involves: 129S4/SvJae * C57BL/6 		abnormal blood vessel morphology J:86542
abnormal kidney vasculature morphology J:86542
abnormal pericyte morphology J:86542
abnormal renal glomerulus morphology J:86542
Pdgfrbtm9Sor/Pdgfrbtm9Sor
involves: 129S4/SvJae * C57BL/6 		abnormal blood vessel morphology J:86542
abnormal kidney vasculature morphology J:86542
abnormal pericyte morphology J:86542
abnormal retina layer morphology J:86542
abnormal retina vasculature morphology J:86542
Pdgfrbtm10Sor/Pdgfrbtm10Sor
involves: 129S4/SvJae * C57BL/6 		hemorrhage J:86542
hydrops fetalis J:86542
intracranial hemorrhage J:86542
kidney hemorrhage J:86542
perinatal lethality J:86542
skin hemorrhage J:86542
Pdgfrbtm11Sor/Pdgfrbtm11Sor
Tg(Nr5a1-cre)2Klp/0
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		normal reproductive system phenotype J:142042
Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 		no abnormal phenotype detected J:173602
Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA 		no abnormal phenotype detected J:173602
Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 		postnatal growth retardation J:173602
postnatal lethality, complete penetrance J:173602
Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA 		increased aorta wall thickness J:173602
postnatal growth retardation J:173602
postnatal lethality, complete penetrance J:173602
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory