Pdgfrb^tm11Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm11Sor
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 11, Philippe Soriano
• MGI ID: MGI:3526812
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm11Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142042
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted at a BstEII and a HpaI site about 500 base pairs upstream of and 2,100 base pairs downstream from the exons encoding the first and second immunoglobulin domain, respectively. Additionally, a FRT-flanked PGKneo cassette was inserted and then removed by crossing with Gt(ROSA)26Sor^tm1(FLP1)Dym mice. (J:142042)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 84 strains or lines available

References

• Original: J:142042 Schmahl J, et al., The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 2008 Dec 1;22(23):3255-67
• All: 16 reference(s)