All Phenotypes Pdgfrb<tm11Sor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdgfrb^tm11Sor
targeted mutation 11, Philippe Soriano
MGI:3526812

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823038
cn2	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823039
cn3	Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs Pdgfrb^tm11Sor/Pdgfrb^tm11Sor	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:3842679

Allelic Composition	Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm11Sor mutation (1 available); any Pdgfrb mutation (84 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:142042 )

N	• mutants are viable and fertile

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Pdgfrb^tm11Sor mutation (1 available); any Pdgfrb mutation (84 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:142042 )

• few mutants are recovered after birth, however mutants are recovered at E18.5, indicating perinatal lethality

endocrine/exocrine glands

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

abnormal adrenal gland morphology ( J:142042 )

• reduction in steroid-producing cells in the adrenal glands at E18.5

abnormal adrenal cortex morphology ( J:142042 )

• reduction in adrenal cortex

small adrenal glands ( J:142042 )

• small adrenal glands are seen just before birth (E18.5)

abnormal testis morphology ( J:142042 )

• reduction in steroid-producing cells in the testis at E18.5

small testis ( J:142042 )

• small testes at E18.5

cardiovascular system

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

reproductive system

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

abnormal testis morphology ( J:142042 )

• reduction in steroid-producing cells in the testis at E18.5

small testis ( J:142042 )

• small testes at E18.5

Allelic Composition	Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs Pdgfrb^tm11Sor/Pdgfrb^tm11Sor
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm3(cre)Cjs mutation (0 available); any Cdkn2a mutation (62 available)
Cdkn2a^tm4Cjs mutation (2 available); any Cdkn2a mutation (62 available)
Pdgfrb^tm11Sor mutation (1 available); any Pdgfrb mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:147752 )

N	• at 3 months of age, all mutants have normal visual acuity • no retinal pathology is evident and vitreous is clear • normal vision is in contrast to Cdnk2a compound heterozygotes not carrying the floxed Pdgfr allele which show significantly compromised visual acuity

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