Pdgfrb^tm1Msas
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm1Msas
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 1, Masakiyo Sasahara
• MGI ID: MGI:3641430
• Synonyms: PDGFR-B^flox, PDGFR-B^flox007
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm1Msas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110798
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A 3.3 kb fragment containing exons 4-7 were flanked by loxP sites positioned in introns 3 and 7. (J:110798)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 84 strains or lines available

References

• Original: J:110798 Gao Z, et al., Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing. J Biol Chem. 2005 Mar 11;280(10):9375-89
• All: 19 reference(s)