Phenotypes Associated with This Genotype

Genotype
MGI:5790635

• Allelic Composition: Pdgfrb^tm1Msas/Pdgfrb^tm1Msas; Tg(Nes-cre)1Nogu/0
• Genetic Background: B6J.Cg-Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal social investigation ( J:229179 )

♂ • mice exhibit social interaction deficits, showing increased non-affiliate behavior (leaving), and decreased active social contact and passive social contact compared to controls

♂ • treatment with the drug T-817MA ameliorates these social behavior deficits

nervous system

decreased neuron number ( J:229179 )

♂ • mice show reduced density of parvalbumin-immunoreactive neurons in the medical prefrontal cortex, hippocampus, amygdala, and superior colliculus

♂ • treatment with the drug T-817MA restores the number of parvalbumin+ neurons

abnormal nervous system electrophysiology ( J:229179 )

♂ • mice exhibit a reduction in auditory phase-locked gamma oscillations

♂ • treatment with the drug T-817MA restores regular phase-locked gamma oscillations

reduced sensorimotor gating ( J:229179 )

♂ • mice show deficits in sensorimotor gating

♂ • treatment with the drug T-817MA ameliorates sensorimotor gating defects

decreased prepulse inhibition ( J:229179 )

♂ • mice show deficits in prepulse inhibition

♂ • treatment with the drug T-817MA ameliorates sensorimotor gating defects

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:229179
schizophrenia		DOID:5419	OMIM:181500	J:229179