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Nras Gene Detail
Summary
  • Symbol
    Nras
  • Name
    neuroblastoma ras oncogene
  • Synonyms
    N-ras
  • Feature Type
    protein coding gene
  • IDs
    MGI:97376
    NCBI Gene: 18176
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:103058285-103067914 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.25 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97376
protein coding gene Chr3:103058285-103067914 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027689
protein coding gene Chr3:104301306-104310931 (+)
A/J MGP_AJ_G0027648
protein coding gene Chr3:100987493-100997716 (+)
AKR/J MGP_AKRJ_G0027614
protein coding gene Chr3:103475372-103484962 (+)
BALB/cJ MGP_BALBcJ_G0027661
protein coding gene Chr3:100759638-100769537 (+)
C3H/HeJ MGP_C3HHeJ_G0027390
protein coding gene Chr3:103792115-103810900 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028104
protein coding gene Chr3:108168617-108179281 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025445
protein coding gene Chr3:97130016-97141198 (+)
CAST/EiJ MGP_CASTEiJ_G0026847
protein coding gene Chr3:102910356-102920591 (+)
CBA/J MGP_CBAJ_G0027365
protein coding gene Chr3:111861092-111871264 (+)
DBA/2J MGP_DBA2J_G0027508
protein coding gene Chr3:100239417-100253674 (+)
FVB/NJ MGP_FVBNJ_G0027476
protein coding gene Chr3:98170011-98179533 (+)
LP/J MGP_LPJ_G0027615
protein coding gene Chr3:105631534-105641176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027505
protein coding gene Chr3:118025382-118035036 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028159
protein coding gene Chr3:102981684-102991279 (+)
PWK/PhJ MGP_PWKPhJ_G0026573
protein coding gene Chr3:99980770-99990950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026395
protein coding gene Chr3:101073709-101079460 (+)
WSB/EiJ MGP_WSBEiJ_G0026926
protein coding gene Chr3:103552162-103561788 (+)



Homology
more
  • Human Ortholog
    NRAS, NRAS proto-oncogene, GTPase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NRAS, NRAS proto-oncogene, GTPase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALPS4, CMNS, NCMS, N-ras, NRAS1, NS6
  • Links
    NCBI Gene ID: 4893
    neXtProt AC: NX_P01111
    UniProt: P01111

  • Chr Location
    1p13.2; chr1:114704464-114716894 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    5 with human NRAS associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 8 alleles in 10 genetic backgrounds
    53 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are viable and fertile with no gross morphological or histological abnormalities, or defects in peripheral blood cell populations. Mice homozygous for an LTR insertion in intron 1 exhibit weight loss immune defectsand postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18176 NCBI Gene Model | MGI Sequence Detail 9630 C57BL/6J ±  kb
    transcript NM_010937 RefSeq | MGI Sequence Detail 4470 Not Specified  
    polypeptide P08556 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001806 Small GTPase
      IPR020849 Small GTPase superfamily, Ras-type
      IPR005225 Small GTP-binding protein domain
    Molecular
    Reagents
    less
    • All nucleic 207
      Genomic 13
      cDNA 188
      Primer pair 3
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12932, MGI:2139934
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 11
      Phenotypes 80
    • Earliest
      J:261 GREEN MC, The position of luxoid in linkage group II of the mouse. J Hered. 1961 Nov-Dec;52:297-300
    • Latest
      J:265335 Reichenbach B, et al., Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. EMBO J. 2018 May 2;37(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory