About   Help   FAQ
Nras
Gene Detail
Symbol

Name
ID
Nras
neuroblastoma ras oncogene
MGI:97376
Synonyms
N-ras
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr3:103058339-103067914 bp, + strand
From VEGA annotation of GRCm38

  9576 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NRAS
Protein SuperFamily: ras protein
Gene Tree: Nras

Human
homologs
NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4893
neXtProt AC: NX_P01111

Human Synonyms: ALPS4, CMNS, NCMS, N-ras, NRAS1, NS6

Human Chr (Location): 1p13.2; chr1:114704464-114716894 (-)  GRCh38.p2

Disease Associations: (8) Diseases Associated with Human NRAS

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(30) Targeted(12) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation are viable and fertile with no gross morphological or histological abnormalities, or defects in peripheral blood cell populations. Mice homozygous for an LTR insertion in intron 1 exhibit weight loss immune defects and postnatal lethality.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Nras interacts with 369 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (118)    Tissues (49)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
Western blot 13
RT-PCR 36
cDNA source data(184)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nras ; ZFIN nras    NEW 
Molecular
reagents
All nucleic(203) Genomic(13) cDNA(186) Primer pair(1) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021269 (Evidence)
Ensembl Gene Model ENSMUSG00000027852 (Evidence)
Entrez Gene 18176 (Evidence)
UniGene 400954
DFCI TC1574136, TC1612864, TC1763053
DoTS DT.101384061, DT.529712, DT.94339287
NIA Mouse Gene Index U003655
Consensus CDS Project CCDS38570.1
International Mouse Phenotyping Consortium Status Nras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021269 VEGA Gene Model | MGI Sequence Detail 9576 C57BL/6J ±  kb
transcript OTTMUST00000050411 VEGA | MGI Sequence Detail 4416 Not Applicable 
polypeptide OTTMUSP00000023521 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(14) UniProt(6)
Polymorphisms
RFLP(5) : SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000011416 GTPase NRas
References
(Earliest) J:7034 Shimizu K, et al., Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6
(Latest) J:220778 Burgess MR, et al., Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 2014 Dec 18;124(26):3947-55
All references(111)
Other
accession IDs
MGD-MRK-12932, MGI:2139934

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory