About   Help   FAQ
Nras
Gene Detail
Symbol

Name
ID
Nras
neuroblastoma ras oncogene
MGI:97376
Synonyms
N-ras
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr3:103058339-103067914 bp, + strand
From VEGA annotation of GRCm38

  9576 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Nras

Human
homologs
Human Homolog NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog
NCBI Gene ID 4893
neXtProt AC  NX_P01111
Human Synonyms  ALPS4, CMNS, NCMS, N-ras, NRAS1, NS6
Human Chr (Location)  1p13.2; chr1:114704464-114716894 (-)  GRCh38
Disease Associations  (7) Diseases Associated with Human NRAS
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(30) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation are viable and fertile with no gross morphological or histological abnormalities, or defects in peripheral blood cell populations. Mice homozygous for an LTR insertion in intron 1 exhibit weight loss immune defects and postnatal lethality.
 
Interactions
Nras interacts with 369 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process GTP catabolic process, negative regulation of skeletal muscle tissue development, ...
Component extracellular vesicular exosome, Golgi apparatus, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (118)    Tissues (49)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
Western blot 13
RT-PCR 36
cDNA source data(184)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(203) Genomic(13) cDNA(186) Primer pair(1) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021269 (Evidence)
Ensembl Gene ModelENSMUSG00000027852 (Evidence)
Entrez Gene18176 (Evidence)
UniGene400954
DFCITC1574136, TC1612864, TC1763053
DoTSDT.101384061, DT.529712, DT.94339287
NIA Mouse Gene IndexU003655
Consensus CDS ProjectCCDS38570.1
International Mouse Knockout Project StatusNras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021269 VEGA Gene Model | MGI Sequence Detail 9576 C57BL/6J ±  kb
transcript OTTMUST00000050411 VEGA | MGI Sequence Detail 4416 Not Applicable 
polypeptide OTTMUSP00000023521 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(14) UniProt(11)
Polymorphisms
RFLP(5) : SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000011416 GTPase NRas
References
(Earliest) J:7034 Shimizu K, et al., Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6
(Latest) J:212912 Kong G, et al., Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. J Clin Invest. 2014 Jun 2;124(6):2762-73
All references(114)
Other
accession IDs
MGD-MRK-12932, MGI:2139934

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory