Nras
Gene Detail

Symbol Name ID

Nras neuroblastoma ras oncogene MGI:97376

Synonyms

N-ras

Feature Type

protein coding gene

Genetic Map

Chromosome 3

45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr3:103058339-103067914 bp, + strand From VEGA annotation of GRCm38   9576 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Nras

Human homologs

Human Homolog		NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog
NCBI Gene ID		4893
neXtProt AC		NX_P01111
Human Synonyms		ALPS4, N-ras, NRAS1, NS6
Human Chr (Location)		1p13.2; chr1:115247085-115259515 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human NRAS

Alleles and phenotypes

All alleles(38) : Targeted(8) Gene trapped(30)
 

Mice homozygous for a targeted mutation are viable and fertile with no gross morphological or histological abnormalities, or defects in peripheral blood cell populations.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	GTP catabolic process, Ras protein signal transduction, ...
Component	Golgi apparatus, membrane, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (118)    Tissues (49)    Images (18)
Theiler Stages: 2, 3, 19, 22, 23, 24, 28

Assay Type	Results
RNA in situ	69
Western blot	13
RT-PCR	36

cDNA source data(179)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(198) Genomic(13) cDNA(181) Primer pair(1) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021269 (Evidence)
Ensembl Gene Model	ENSMUSG00000027852 (Evidence)
Entrez Gene	18176 (Evidence)
UniGene	400954
DFCI	TC1574136, TC1612864, TC1763053
DoTS	DT.101384061, DT.529712, DT.94339287
NIA Mouse Gene Index	U003655
Consensus CDS Project	CCDS38570.1
International Mouse Knockout Project Status	Nras

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021269	VEGA Gene Model | MGI Sequence Detail	9576	C57BL/6J
transcript	OTTMUST00000050411	VEGA | MGI Sequence Detail	4416	Not Applicable
polypeptide	OTTMUSP00000023521	VEGA | MGI Sequence Detail	189	Not Applicable

All sequences(48) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(5) : SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR020849	Small GTPase superfamily, Ras type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000011416	GTPase NRas

References

(Earliest) J:7034 Shimizu K, et al., Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6
(Latest) J:190123 Huelsenbeck J, et al., Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin. FEBS Lett. 2012 Oct 19;586(20):3665-73
All references(99)

Other accession IDs

MGD-MRK-12932, MGI:2139934