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Symbol
Name
ID
Nras
neuroblastoma ras oncogene
MGI:97376
Phenotype annotations related to neoplasm
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Leukemia
Acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemias
Acute myeloid leukemia
Juvenile myelomonocytic leukemia
Lymphoma
Lymphoproliferative disorder
Multiple myeloma
Myelodysplasia
Adenoma sebaceum
Hemangioma
Cavernous hemangioma
Hereditary nonpolyposis colorectal carcinoma
Neoplasm of the stomach
Hepatocellular carcinoma
Non-medullary thyroid carcinoma
Papillary thyroid carcinoma
Uterine leiomyosarcoma
Renal cell carcinoma
Transitional cell carcinoma of the bladder
Neoplasm of the skin
Basal cell carcinoma
Cutaneous melanoma
Rhabdomyosarcoma
Neoplasm
Sarcoma
Disease(s) Associated with NRAS
acute lymphoblastic leukemia
acute myeloid leukemia
autoimmune lymphoproliferative syndrome type 4
colorectal cancer
hepatocellular carcinoma
large congenital melanocytic nevus
linear nevus sebaceous syndrome
multiple myeloma
myelodysplastic syndrome
Noonan syndrome 6
thyroid gland papillary carcinoma

Mouse Phenotypes
neoplasm
increased acute lymphoblastic leukemia incidence
increased melanoma incidence
Availability Mouse Genotype
Nrastm1Tyj/Nrastm1Tyj
Tg(Mx1-cre)1Cgn/0  (conditional)
Nrastm1Tyj/Nrastm1Tyj
Tg(Tyr-cre/ERT2)1Lru/0  (conditional)
*
Nrastm1Tyj/Nrastm1Tyj
Tg(Tyr-cre)1Lru/0  (conditional)
Meox2tm1(cre)Sor/?
Nrastm1Zhng/Nrastm1Zhng  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory