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Il2 Gene Detail
Summary
  • Symbol
    Il2
  • Name
    interleukin 2
  • Synonyms
    IL-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96548
    NCBI Gene: 16183
  • Gene Overview
    MyGene.info: IL2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:37120713-37125954 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 18.30 cM, cytoband B-C
  • Mapping Data
    35 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96548
protein coding gene Chr3:37120523-37125959 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027166
protein coding gene Chr3:34965375-34970738 (-)
A/J MGP_AJ_G0027126
protein coding gene Chr3:34270359-34275797 (-)
AKR/J MGP_AKRJ_G0027095
protein coding gene Chr3:34906358-34913994 (-)
BALB/cJ MGP_BALBcJ_G0027138
protein coding gene Chr3:34020817-34026126 (-)
C3H/HeJ MGP_C3HHeJ_G0026881
protein coding gene Chr3:34964408-34971450 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027584
protein coding gene Chr3:36596469-36603033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024945
protein coding gene Chr3:31949970-31955112 (-)
CAST/EiJ MGP_CASTEiJ_G0026334
protein coding gene Chr3:34829960-34835250 (-)
CBA/J MGP_CBAJ_G0026858
protein coding gene Chr3:37582016-37587469 (-)
DBA/2J MGP_DBA2J_G0026992
protein coding gene Chr3:33708216-33713659 (-)
FVB/NJ MGP_FVBNJ_G0026960
protein coding gene Chr3:33151123-33156559 (-)
LP/J MGP_LPJ_G0027104
protein coding gene Chr3:35739981-35746725 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0027643
protein coding gene Chr3:34759382-34766695 (-)
PWK/PhJ MGP_PWKPhJ_G0026067
protein coding gene Chr3:33394689-33400140 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025879
protein coding gene Chr3:34125007-34131586 (-)
WSB/EiJ MGP_WSBEiJ_G0026408
protein coding gene Chr3:34783833-34790884 (-)



Homology
more
  • Human Ortholog
    IL2, interleukin 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL2, interleukin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-2, lymphokine, TCGF
  • Links
    NCBI Gene ID: 3558
    neXtProt AC: NX_P60568
    UniProt: P60568

  • Chr Location
    4q27; chr4:122449479-122456495 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Il2 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 4 alleles in 11 genetic backgrounds
    34 phenotypes from multigenic genotypes
    197 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants develop adult onset autoimmune disease, with 50% mortality by 9 weeks due to hemolytic anemia. Survivors develop inflammatory bowl disease/colitis. Immune system dysregulation and CD4+ T-cell overproduction may be responsible.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16183 NCBI Gene Model | MGI Sequence Detail 5242 C57BL/6J ±  kb
    transcript NM_008366 RefSeq | MGI Sequence Detail 955 C57BL/6  
    polypeptide P04351 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 12
      cDNA 15
      Primer pair 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11353, MGD-MRK-11374
    References
    more
    • Summaries
      All 534
      Developmental Gene Expression 11
      Diseases 4
      Gene Ontology 29
      Phenotypes 197
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:265031 Sequeira I, et al., Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018 Aug 24;9(1):3437

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory