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Il2
Gene Detail
 Symbol
Name
ID
Il2
interleukin 2
MGI:96548
STS D3Mit21, D3Ncvs11, D3Nds27, D3Nds6
Synonyms IL-2
Feature Type protein coding gene
Genetic Map
Chromosome 3
18.30 cM, cytoband B-C
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr3:37120523-37125959 bp, - strand
From VEGA annotation of GRCm38

  5437 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-2
Gene Tree: Il2

Human
homologs
Human Homolog IL2, interleukin 2
NCBI Gene ID 3558
neXtProt AC  NX_P60568
Human Synonyms  IL-2, lymphokine, TCGF
Human Chr (Location)  4q26-q27; chr4:122451470-122456495 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mutants develop adult onset autoimmune disease, with 50% mortality by 9 weeks due to hemolytic anemia. Survivors develop inflammatory bowl disease/colitis. Immune system dysregulation and CD4+ T-cell overproduction may be responsible.
 
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process extrinsic apoptotic signaling pathway in absence of ligand, G-protein coupled receptor signaling pathway, ...
Component extracellular region, extracellular space
Function carbohydrate binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (30)    Tissues (16)   
Theiler Stages: 21, 22, 23, 24, 25, 26
Assay TypeResults
RT-PCR 30
cDNA source data(15)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(38) Genomic(12) cDNA(15) Primer pair(10) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007347 (Evidence)
Ensembl Gene ModelENSMUSG00000027720 (Evidence)
Entrez Gene16183 (Evidence)
UniGene14190
DFCITC1587787, TC1591362, TC1657200
DoTSDT.40158060, DT.91336188
NIA Mouse Gene IndexU023954
Consensus CDS ProjectCCDS17316.1
International Mouse Knockout Project StatusIl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007347 VEGA Gene Model | MGI Sequence Detail 5437 C57BL/6J ±  kb
transcript OTTMUST00000016996 VEGA | MGI Sequence Detail 1144 Not Applicable 
polypeptide OTTMUSP00000007837 VEGA | MGI Sequence Detail 169 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(2) UniProt(10)
Polymorphisms All PCR and RFLP(9) : PCR(7) RFLP(2) SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000779 Interleukin-2
Protein Ontology PR:000001379 interleukin-2
References (Earliest) J:7697 Fuse A, et al., Organization and structure of the mouse interleukin-2 gene. Nucleic Acids Res. 1984 Dec 21;12(24):9323-31
(Latest) J:209356 Vogelzang A, et al., IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. J Immunol. 2014 Feb 15;192(4):1404-14
All references(412)
Other
accession IDs
MGD-MRK-11353, MGD-MRK-11374

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory