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Il2 Gene Detail
Summary
  • Symbol
    Il2
  • Name
    interleukin 2
  • Synonyms
    IL-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96548
    NCBI Gene: 16183
  • Gene Overview
    MyGene.info: IL2
Location & Maps
more
  • Sequence Map
    Chr3:37120523-37125959 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5437 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 18.30 cM, cytoband B-C
  • Mapping Data
    35 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    IL2, interleukin 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL2, interleukin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-2, lymphokine, TCGF
  • Links
    NCBI Gene ID: 3558
    neXtProt AC: NX_P60568

  • Chr Location
    4q26-q27; chr4:122451470-122456495 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    92 phenotypes from 4 alleles in 11 genetic backgrounds
    34 phenotypes from multigenic genotypes
    194 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Il2
  • Incidental Mutations
    APF
Homozygous null mutants develop adult onset autoimmune disease, with 50% mortality by 9 weeks due to hemolytic anemia. Survivors develop inflammatory bowl disease/colitis. Immune system dysregulation and CD4+ T-cell overproduction may be responsible.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007347 VEGA Gene Model | MGI Sequence Detail 5437 C57BL/6J ±  kb
transcript OTTMUST00000016996 VEGA | MGI Sequence Detail 1144 Not Applicable  
polypeptide OTTMUSP00000007837 VEGA | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 38
    Genomic 12
    cDNA 15
    Primer pair 10
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11353, MGD-MRK-11374
References
more
  • Summaries
    All 431
    Developmental Gene Expression 10
    Gene Ontology 29
    Phenotypes 194
  • Earliest
    J:7697 Fuse A, et al., Organization and structure of the mouse interleukin-2 gene. Nucleic Acids Res. 1984 Dec 21;12(24):9323-31
  • Latest
    J:233908 Magalhaes D, et al., Role of epithelial ion transports in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G460-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory