98 phenotypes from 4 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il2m1/Il2m1 MRL/MpJ	abnormal T cell activation	J:75331
Il2tm1.1Flv/Il2tm1.1Flv NOD/ShiLtJ-Il2tm1.1Flv	abnormal susceptibility to autoimmune disorder	J:150823
Il2tm1.1Kasm/Il2tm1.1Kasm Ndor1Tg(UBC-cre/ERT2)1Ejb/? involves: 129S/SvEv * C57BL/6	abnormal cellular respiration	J:190168
	decreased circulating interleukin-17 level	J:190168
	normal immune system phenotype	J:190168
Il2tm1Hor/Il2+ NOD.129P2(B6)-Il2tm1Hor/DvsJ	increased susceptibility to autoimmune diabetes	J:120349
Il2tm1Hor/Il2tm1Hor B6.129P2-Il2tm1Hor	normal immune system phenotype	J:125748
	increased activated T cell number	J:28924
	increased CD4-positive, alpha-beta T cell number	J:28924
	increased CD8-positive, alpha-beta T cell number	J:28924
	increased T cell number	J:125748
	increased T cell proliferation	J:28924
Il2tm1Hor/Il2tm1Hor B6.129P2-Il2tm1Hor/J	abnormal cellular respiration	J:190168
	abnormal circulating cytokine level	J:190168
	abnormal response to transplant	J:113547
	abnormal salivary gland duct morphology	J:125129
	abnormal salivary gland morphology	J:125129
	abnormal T cell activation	J:190168
	abnormal T cell proliferation	J:190168
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:131774
	decreased circulating interferon-gamma level	J:190168
	decreased circulating interleukin-4 level	J:190168
	decreased circulating interleukin-13 level	J:190168
	decreased regulatory T cell number	J:113547
	decreased salivation	J:125129
	enlarged lymph nodes	J:113547
	increased CD4-positive, alpha-beta T cell number	J:131774
	increased splenocyte number	J:131774
	increased susceptibility to autoimmune disorder	J:113547
	lacrimal gland inflammation	J:125129
	large intestinal inflammation	J:125129
	salivary gland inflammation	J:125129
Il2tm1Hor/Il2tm1Hor C3.129P2-Il2tm1Hor	increased CD4-positive, alpha-beta T cell number	J:28924
	increased CD8-positive, alpha-beta T cell number	J:28924
Il2tm1Hor/Il2tm1Hor C.129P2-Il2tm1Hor	abnormal bone marrow cell number	J:29799
	abnormal lymphocyte morphology	J:29799
	abnormal regulatory T cell physiology	J:112603
	abnormal reticulocyte morphology	J:29799
	abnormal spleen morphology	J:29799
	decreased hematocrit	J:29799
	enlarged lymph nodes	J:29799
	heart inflammation	J:29799
	increased B cell proliferation	J:29799
	increased circulating bilirubin level	J:29799
	increased germinal center B cell number	J:29799
	increased IgG level	J:29799
	increased inflammatory response	J:29799
	increased mean corpuscular hemoglobin	J:29799
	increased plasma cell number	J:29799
	increased spleen red pulp amount	J:29799
	increased susceptibility to autoimmune hemolytic anemia	J:29799
	increased T cell proliferation	J:29799
	liver inflammation	J:29799
	low mean erythrocyte cell number	J:29799
	lung inflammation	J:29799
	pancreas inflammation	J:29799
	premature death	J:29799
	spleen hyperplasia	J:29799
	vascular inflammation	J:29799
Il2tm1Hor/Il2tm1Hor involves: 129P2/OlaHsd	increased regulatory T cell number	J:208318
	normal reproductive system phenotype	J:134589
Il2tm1Hor/Il2tm1Hor involves: 129P2/OlaHsd * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:15573, J:39981, J:39989
	abnormal CD8 positive, alpha-beta intraepithelial T cell morphology	J:15223, J:39981
	abnormal class switch recombination	J:15573
	abnormal colon goblet cell morphology	J:15223, J:29999
	abnormal cytotoxic T cell physiology	J:39981
	abnormal gamma-delta intraepithelial T cell morphology	J:15223
	abnormal intestinal epithelium morphology	J:15223, J:29999
	abnormal level of surface class II molecules	J:15223
	abnormal lymphocyte cell number	J:15223
	abnormal lymphocyte morphology	J:37220
	abnormal lymphocyte physiology	J:15223
	abnormal susceptibility to Riboviria infection	J:26861
	abnormal T-helper 1 cell differentiation	J:37220
	abnormal thymocyte activation	J:37220, J:39989
	amyloidosis	J:15223
	anemia	J:15223, J:29999
	cachexia	J:29999
	chronic diarrhea	J:15223
	colitis	J:15223, J:29999, J:37220
	crypts of Lieberkuhn abscesses	J:15223
	decreased cytotoxic T cell cytolysis	J:15573, J:26198, J:26861
	decreased double-negative T cell number	J:15223
	decreased double-positive T cell number	J:37220
	decreased splenocyte proliferation	J:79241
	decreased T cell proliferation	J:26198, J:39989
	diarrhea	J:29999
	enlarged lymph nodes	J:15223
	enlarged mesenteric lymph nodes	J:29999
	enlarged spleen	J:15223
	hunched posture	J:29999
	impaired natural killer cell mediated cytotoxicity	J:15573
	increased B cell proliferation	J:16662
	increased double-negative T cell number	J:37220
	increased IgA level	J:15223
	increased IgE level	J:16662
	increased IgG1 level	J:15223, J:16662, J:39989
	increased IgG2a level	J:16662
	increased IgG2b level	J:16662
	increased length of allograft survival	J:26198
	increased pre-B cell number	J:16662
	increased pro-B cell number	J:16662
	increased single-positive T cell number	J:37220
	increased T cell proliferation	J:15223, J:16662
	intestinal ulcer	J:15223
	lymph node hyperplasia	J:16662
	premature death	J:15223
	rectal hemorrhage	J:29999
	rectal prolapse	J:15223, J:29999
Il2tm1Hor/Il2tm1Hor involves: 129P2/OlaHsd * C57BL/6J	increased circulating interleukin-17 level	J:120176
	increased T-helper 17 cell number	J:120176