Il2^tm1.1Flv
Targeted Allele Detail

Summary

• Symbol: Il2^tm1.1Flv
• Name: interleukin 2; targeted mutation 1.1, Richard A Flavell
• MGI ID: MGI:3852346
• Synonyms: NOD.IL-2B6ex1
• Gene: Il2 Location: Chr3:37174862-37180103 bp, - strand Genetic Position: Chr3, 18.3 cM, cytoband B-C
• Alliance: Il2^tm1.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150823
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S1/SvImJ x NOD/ShiLtJ)F1

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 through part of intron 2 was replaced with the corresponding sequence from C57BL/6 mice. Although the ES cells used to create this allele were (129S1/SvImJ x NOD/ShiLtJ)F1 the targeting event was mapped to the NOD allele. The floxed neo cassette downstream of the inserted sequence was removed by transient cre expression in ES cells. (J:150823)

Generation of the Il2^tm1.1Flv allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il2 Mutation: 41 strains or lines available

References

• Original: J:150823 Kamanaka M, et al., Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11236-40
• All: 1 reference(s)