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Il1b
Gene Detail
Symbol

Name
ID
Member of
Il1b
interleukin 1 beta
MGI:96543
Il1 cluster
Synonyms
IL-1B, IL-1beta
Feature Type
protein coding gene
Genetic Map
Chromosome 2
62.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr2:129364570-129371139 bp, - strand
From VEGA annotation of GRCm38

  6570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: interleukin-1
Gene Tree: Il1b

Human
homologs
Human Homolog IL1B, interleukin 1, beta
NCBI Gene ID 3553
neXtProt AC  NX_P01584
Human Synonyms  IL-1, IL1-BETA, IL1F2
Human Chr (Location)  2q14; chr2:112829751-112836779 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IL1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis.
 
Interactions
Il1b interacts with 96 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (114 annotations)
Process activation of MAPK activity, aging, ...
Component cell, cytosol, ...
Function cytokine activity, interleukin-1 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (89)    Tissues (64)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 89
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(4) cDNA(13) Primer pair(8) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015509 (Evidence)
Ensembl Gene ModelENSMUSG00000027398 (Evidence)
Entrez Gene16176 (Evidence)
UniGene222830
DFCITC1585020
DoTSDT.101349833, DT.40168652, DT.91592248
NIA Mouse Gene IndexU023344
PDB2MIB, 8I1B
Consensus CDS ProjectCCDS16726.1
International Mouse Knockout Project StatusIl1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015509 VEGA Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
transcript OTTMUST00000036830 VEGA | MGI Sequence Detail 1356 Not Applicable 
polypeptide OTTMUSP00000016525 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(9) : PCR(7) RFLP(2) SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR003294 Interleukin-1, alpha/beta
InterPro IPR003296 Interleukin-1, beta IL1B
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003502 Interleukin-1 propeptide
Protein Ontology PR:000001136 interleukin-1 beta
References
(Earliest) J:8581 Telford JL, et al., The murine interleukin 1 beta gene: structure and evolution. Nucleic Acids Res. 1986 Dec 22;14(24):9955-63
(Latest) J:214079 Uri-Belapolsky S, et al., Interleukin-1 deficiency prolongs ovarian lifespan in mice. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12492-7
All references(368)
Other
accession IDs
MGD-MRK-11352, MGD-MRK-11367

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory