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Il1b
Gene Detail
Symbol

Name
ID
Member of
Il1b
interleukin 1 beta
MGI:96543
Il1 cluster
Synonyms
IL-1B, IL-1beta
Feature Type
protein coding gene
Genetic Map
Chromosome 2
62.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr2:129364570-129371139 bp, - strand
From VEGA annotation of GRCm38

  6570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: IL1B
Protein SuperFamily: interleukin-1
Gene Tree: Il1b

Human
homologs
IL1B, interleukin 1, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3553
neXtProt AC: NX_P01584

Human Synonyms: IL-1, IL1-BETA, IL1F2

Human Chr (Location): 2q14; chr2:112829751-112836779 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IL1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(6) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Il1b interacts with 96 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (114 annotations)
Process activation of MAPK activity, aging, ...
Component cytosol, extracellular region, ...
Function cytokine activity, interleukin-1 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (89)    Tissues (64)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 89
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487038 ; ZFIN il1b    NEW 
Molecular
reagents
All nucleic(26) Genomic(4) cDNA(13) Primer pair(8) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015509 (Evidence)
Ensembl Gene Model ENSMUSG00000027398 (Evidence)
Entrez Gene 16176 (Evidence)
UniGene 222830
DFCI TC1585020
DoTS DT.101349833, DT.40168652, DT.91592248
NIA Mouse Gene Index U023344
PDB 2MIB, 8I1B
Consensus CDS Project CCDS16726.1
International Mouse Phenotyping Consortium Status Il1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015509 VEGA Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
transcript OTTMUST00000036830 VEGA | MGI Sequence Detail 1356 Not Applicable 
polypeptide OTTMUSP00000016525 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(9) : PCR(7) RFLP(2) SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR003294 Interleukin-1, alpha/beta
InterPro IPR003296 Interleukin-1, beta IL1B
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003502 Interleukin-1 propeptide
Protein Ontology PR:000001136 interleukin-1 beta
References
(Earliest) J:8581 Telford JL, et al., The murine interleukin 1 beta gene: structure and evolution. Nucleic Acids Res. 1986 Dec 22;14(24):9955-63
(Latest) J:222969 Giannou AD, et al., Mast cells mediate malignant pleural effusion formation. J Clin Invest. 2015 Jun;125(6):2317-34
All references(372)
Other
accession IDs
MGD-MRK-11352, MGD-MRK-11367

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory