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Il1b Gene Detail
Summary
  • Symbol
    Il1b
  • Name
    interleukin 1 beta
  • Synonyms
    IL-1B, IL-1beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96543
    NCBI Gene: 16176
  • Member of
    Il1 cluster
  • Gene Overview
    MyGene.info: IL1B
Location & Maps
more
  • Sequence Map
    Chr2:129364570-129371139 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6570 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.97 cM, cytoband F
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    32 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    IL1B, interleukin 1 beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL1B, interleukin 1 beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IL-1, IL1-BETA, IL1F2
  • Links
    NCBI Gene ID: 3553
    neXtProt AC: NX_P01584

  • Chr Location
    2q14; chr2:112829751-112836779 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL1B associations

Human Disease Mouse Models
       Gastric Cancer, Hereditary Diffuse; HDGC   OMIM: 137215
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 9 genetic backgrounds
    42 phenotypes from multigenic genotypes
    168 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    3
  • Genomic Mutations
    2 involving Il1b
  • Incidental Mutations
Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015509 VEGA Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
transcript OTTMUST00000036830 VEGA | MGI Sequence Detail 1356 Not Applicable  
polypeptide OTTMUSP00000016525 VEGA | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    100 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 26
    Genomic 4
    cDNA 13
    Primer pair 8
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11352, MGD-MRK-11367
References
more
  • Summaries
    All 381
    Developmental Gene Expression 26
    Diseases 2
    Gene Ontology 26
    Phenotypes 168
  • Earliest
    J:8581 Telford JL, et al., The murine interleukin 1 beta gene: structure and evolution. Nucleic Acids Res. 1986 Dec 22;14(24):9955-63
  • Latest
    J:229029 Yamamoto K, et al., The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med. 2015 Oct 19;212(11):1901-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory