Il1b
Gene Detail

Symbol Name ID

Il1b interleukin 1 beta MGI:96543

STS

D2Mit135, D2Nds3

Synonyms

IL-1B, IL-1beta

Feature Type

protein coding gene

Genetic Map

Chromosome 2

62.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(32)

Sequence Map

Chr2:129364570-129371139 bp, - strand From VEGA annotation of GRCm38   6570 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: interleukin-1
Gene Tree: Il1b

Human homologs

Human Homolog		IL1B, interleukin 1, beta
NCBI Gene ID		3553
neXtProt AC		NX_P01584
Human Synonyms		IL-1, IL1-BETA, IL1F2
Human Chr (Location)		2q14; chr2:113587337-113594356 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IL1B

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (107 annotations)

Process	activation of MAPK activity, aging, ...
Component	extracellular region, extracellular space, ...
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (96)    Tissues (63)   
Theiler Stages: 2, 3, 4, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	96

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(4) cDNA(13) Primer pair(8) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015509 (Evidence)
Ensembl Gene Model	ENSMUSG00000027398 (Evidence)
Entrez Gene	16176 (Evidence)
UniGene	222830
DFCI	TC1585020
DoTS	DT.101349833, DT.40168652, DT.91592248
NIA Mouse Gene Index	U023344
PDB	2MIB, 8I1B
Consensus CDS Project	CCDS16726.1
International Mouse Knockout Project Status	Il1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015509	VEGA Gene Model | MGI Sequence Detail	6570	C57BL/6J
transcript	OTTMUST00000036830	VEGA | MGI Sequence Detail	1356	Not Applicable
polypeptide	OTTMUSP00000016525	VEGA | MGI Sequence Detail	269	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(9) : PCR(7) RFLP(2) SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR000975	Interleukin-1
InterPro	IPR003294	Interleukin-1, alpha/beta
InterPro	IPR003296	Interleukin-1, beta IL1B
InterPro	IPR020877	Interleukin-1 conserved site
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
InterPro	IPR003502	Interleukin-1 propeptide
Protein Ontology	PR:000001136	interleukin-1 beta

References

(Earliest) J:8581 Telford JL, et al., The murine interleukin 1 beta gene: structure and evolution. Nucleic Acids Res. 1986 Dec 22;14(24):9955-63
(Latest) J:195858 Nov O, et al., Interleukin-1beta regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. PLoS One. 2013;8(1):e53626
All references(345)

Other accession IDs

MGD-MRK-11352, MGD-MRK-11367