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Il1b Gene Detail
Summary
  • Symbol
    Il1b
  • Name
    interleukin 1 beta
  • Synonyms
    IL-1B, IL-1beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96543
    NCBI Gene: 16176
  • Member of
    Il1 cluster
  • Gene Overview
    MyGene.info: IL1B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129364570-129371139 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.97 cM, cytoband F
  • Mapping Data
    32 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96543
protein coding gene Chr2:129363842-129371170 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026488
protein coding gene Chr2:132756357-132762923 (-)
A/J MGP_AJ_G0026452
protein coding gene Chr2:127373484-127380053 (-)
AKR/J MGP_AKRJ_G0026427
protein coding gene Chr2:130987117-130993683 (-)
BALB/cJ MGP_BALBcJ_G0026464
protein coding gene Chr2:127630840-127637653 (-)
C3H/HeJ MGP_C3HHeJ_G0026207
protein coding gene Chr2:131501934-131508502 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026909
protein coding gene Chr2:136904604-136911167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024286
protein coding gene Chr2:122187052-122193417 (-)
CAST/EiJ MGP_CASTEiJ_G0025668
protein coding gene Chr2:131758351-131764844 (-)
CBA/J MGP_CBAJ_G0026187
protein coding gene Chr2:141966195-141972763 (-)
DBA/2J MGP_DBA2J_G0026321
protein coding gene Chr2:126763085-126769654 (-)
FVB/NJ MGP_FVBNJ_G0026285
protein coding gene Chr2:125409080-125415646 (-)
LP/J MGP_LPJ_G0026426
protein coding gene Chr2:132991823-132998389 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026305
protein coding gene Chr2:145861769-145868339 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026964
protein coding gene Chr2:131032064-131038630 (-)
PWK/PhJ MGP_PWKPhJ_G0025404
protein coding gene Chr2:126344436-126351116 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025207
protein coding gene Chr2:130153763-130160192 (-)
WSB/EiJ MGP_WSBEiJ_G0025742
protein coding gene Chr2:131955502-131963394 (-)



Homology
more
  • Human Ortholog
    IL1B, interleukin 1 beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL1B, interleukin 1 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-1, IL1beta, IL1-BETA, IL1F2
  • Links
    NCBI Gene ID: 3553
    neXtProt AC: NX_P01584
    UniProt: P01584

  • Chr Location
    2q14.1; chr2:112829758-112836842 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IL1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 9 genetic backgrounds
    42 phenotypes from multigenic genotypes
    214 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027398 Ensembl Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
    transcript ENSMUST00000028881 Ensembl | MGI Sequence Detail 1356 Not Applicable  
    polypeptide ENSMUSP00000028881 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 4
      cDNA 14
      Primer pair 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11352, MGD-MRK-11367
    References
    more
    • Summaries
      All 658
      Developmental Gene Expression 44
      Diseases 3
      Gene Ontology 30
      Phenotypes 214
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:278713 Drummond RA, et al., CARD9(+) microglia promote antifungal immunity via IL-1beta- and CXCL1-mediated neutrophil recruitment. Nat Immunol. 2019 May;20(5):559-570

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory