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Il10
Gene Detail
Symbol

Name
ID
Il10
interleukin 10
MGI:96537
Synonyms
cytokine synthesis inhibitory factor, IL-10
Feature Type
protein coding gene
Genetic Map
Chromosome 1
56.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:131019845-131024974 bp, + strand
From VEGA annotation of GRCm38

  5130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IL10
Protein SuperFamily: class 2 cytokine, IL-10 type
Gene Tree: Il10

Human
homologs
IL10, interleukin 10
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3586
neXtProt AC: NX_P22301

Human Synonyms: CSIF, GVHDS, IL-10, IL10A, TGIF

Human Chr (Location): 1q31-q32; chr1:206767602-206774607 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human IL10

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Targeted(14) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani.
 
Human Diseases Modeled in Mice Using Il10 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Il10 interacts with 133 markers (Mir20a, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (13)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 13
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase il10 ; ZFIN il10    NEW 
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(8) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016630 (Evidence)
Ensembl Gene Model ENSMUSG00000016529 (Evidence)
Entrez Gene 16153 (Evidence)
UniGene 874
DFCI TC1591387
DoTS DT.40185436
NIA Mouse Gene Index U000777
PDB 4X51
Consensus CDS Project CCDS15265.1
International Mouse Phenotyping Consortium Status Il10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016630 VEGA Gene Model | MGI Sequence Detail 5130 C57BL/6J ±  kb
transcript OTTMUST00000040224 VEGA | MGI Sequence Detail 1310 Not Applicable 
polypeptide OTTMUSP00000017964 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000098 Interleukin-10
InterPro IPR020443 Interleukin-10/19/20/24
InterPro IPR020423 Interleukin-10, conserved site
Protein Ontology PR:000001471 interleukin-10
References
(Earliest) J:14590 Fiorentino DF, et al., Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989 Dec 1;170(6):2081-95
(Latest) J:219843 Chassaing B, et al., Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
All references(969)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-11347, MGD-MRK-11361

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory