Il10
Gene Detail

Symbol Name ID

Il10 interleukin 10 MGI:96537

Synonyms

cytokine synthesis inhibitory factor, IL-10

Feature Type

protein coding gene

Genetic Map

Chromosome 1

56.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr1:131019845-131024974 bp, + strand From VEGA annotation of GRCm38   5130 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: class 2 cytokine, IL-10 type
Gene Tree: Il10

Human homologs

Human Homolog		IL10, interleukin 10
NCBI Gene ID		3586
neXtProt AC		NX_P22301
Human Synonyms		CSIF, GVHDS, IL-10, IL10A, TGIF
Human Chr (Location)		1q31-q32; chr1:206940948-206945839 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human IL10

Alleles and phenotypes

All alleles(14) : Targeted(14)
 

Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani.

 
Human Diseases Modeled Using Mouse Il10 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	branching involved in labyrinthine layer morphogenesis, defense response to bacterium, ...
Component	extracellular region, extracellular space
Function	cytokine activity, interleukin-10 receptor binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (13)    Tissues (7)    Images (1)
Theiler Stages: 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	13

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(2) cDNA(8) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016630 (Evidence)
Ensembl Gene Model	ENSMUSG00000016529 (Evidence)
Entrez Gene	16153 (Evidence)
UniGene	874
DFCI	TC1591387
DoTS	DT.40185436
NIA Mouse Gene Index	U000777
Consensus CDS Project	CCDS15265.1
International Mouse Knockout Project Status	Il10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016630	VEGA Gene Model | MGI Sequence Detail	5130	C57BL/6J
transcript	OTTMUST00000040224	VEGA | MGI Sequence Detail	1310	Not Applicable
polypeptide	OTTMUSP00000017964	VEGA | MGI Sequence Detail	178	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR000098	Interleukin-10
InterPro	IPR020443	Interleukin-10/19/20/24
InterPro	IPR020423	Interleukin-10, conserved site
Protein Ontology	PR:000001471	interleukin-10

References

(Earliest) J:14590 Fiorentino DF, et al., Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989 Dec 1;170(6):2081-95
(Latest) J:195286 Guo Z, et al., Antisense Oligonucleotide Treatment Enhances the Recovery of Acute Lung Injury through IL-10-Secreting M2-like Macrophage-Induced Expansion of CD4+ Regulatory T Cells. J Immunol. 2013 Apr 15;190(8):4337-48
All references(843)

Other accession IDs

MGD-MRK-11347, MGD-MRK-11361