About   Help   FAQ
Il10 Gene Detail
Summary
  • Symbol
    Il10
  • Name
    interleukin 10
  • Synonyms
    cytokine synthesis inhibitory factor, IL-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96537
    NCBI Gene: 16153
Location & Maps
more
  • Sequence Map
    Chr1:131019845-131024974 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5130 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL10, interleukin 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL10, interleukin 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSIF, GVHDS, IL-10, IL10A, TGIF
  • Links
    NCBI Gene ID: 3586
    neXtProt AC: NX_P22301

  • Chr Location
    1q31-q32; chr1:206767602-206774607 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Il10 mouse models; 3 with human IL10 associations

Human Disease Mouse Models
       Inflammatory Bowel Disease 23; IBD23   OMIM: 612381 View 3 models
       Graft-Versus-Host Disease, Susceptibility To; GVHDS   OMIM: 614395
Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Rheumatoid Arthritis; RA   OMIM: 180300
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    152 phenotypes from 11 alleles in 16 genetic backgrounds
    58 phenotypes from multigenic genotypes
    2 images
    733 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    14
  • Transgenic
    3
  • Genomic Mutations
    3 involving Il10
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016630 VEGA Gene Model | MGI Sequence Detail 5130 C57BL/6J ±  kb
transcript OTTMUST00000040224 VEGA | MGI Sequence Detail 1310 Not Applicable  
polypeptide OTTMUSP00000017964 VEGA | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    69 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 8
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11347, MGD-MRK-11361
References
more
  • Summaries
    All 996
    Developmental Gene Expression 8
    Diseases 10
    Gene Ontology 24
    Phenotypes 733
  • Earliest
    J:14590 Fiorentino DF, et al., Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989 Dec 1;170(6):2081-95
  • Latest
    J:228206 Hos D, et al., IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages. Am J Pathol. 2016 Jan;186(1):159-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory