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Il10
Gene Detail
 Symbol
Name
ID
Il10
interleukin 10
MGI:96537
Synonyms cytokine synthesis inhibitory factor, IL-10
Feature Type protein coding gene
Genetic Map
Chromosome 1
56.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:131019845-131024974 bp, + strand
From VEGA annotation of GRCm38

  5130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: class 2 cytokine, IL-10 type
Gene Tree: Il10

Human
homologs
Human Homolog IL10, interleukin 10
NCBI Gene ID 3586
neXtProt AC  NX_P22301
Human Synonyms  CSIF, GVHDS, IL-10, IL10A, TGIF
Human Chr (Location)  1q31-q32; chr1:206767603-206772494 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human IL10
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani.
 
Human Diseases Modeled Using Mouse Il10 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Il10 interacts with 133 markers (Mir20a, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process branching involved in labyrinthine layer morphogenesis, cellular response to lipopolysaccharide, ...
Component extracellular region, extracellular space
Function cytokine activity, interleukin-10 receptor binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (13)    Tissues (7)    Images (1)
Theiler Stages: 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RT-PCR 13
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(8) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016630 (Evidence)
Ensembl Gene ModelENSMUSG00000016529 (Evidence)
Entrez Gene16153 (Evidence)
UniGene874
DFCITC1591387
DoTSDT.40185436
NIA Mouse Gene IndexU000777
Consensus CDS ProjectCCDS15265.1
International Mouse Knockout Project StatusIl10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016630 VEGA Gene Model | MGI Sequence Detail 5130 C57BL/6J ±  kb
transcript OTTMUST00000040224 VEGA | MGI Sequence Detail 1310 Not Applicable 
polypeptide OTTMUSP00000017964 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000098 Interleukin-10
InterPro IPR020443 Interleukin-10/19/20/24
InterPro IPR020423 Interleukin-10, conserved site
Protein Ontology PR:000001471 interleukin-10
References (Earliest) J:14590 Fiorentino DF, et al., Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989 Dec 1;170(6):2081-95
(Latest) J:210354 Chen X, et al., Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice. Neuroscience. 2014 Apr 25;266:235-43
All references(938)
Disease annotation references (6)
Other
accession IDs
MGD-MRK-11347, MGD-MRK-11361

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory