152 phenotypes from 11 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19tm1(cre)Cgn/Cd19+ Il10tm1Roer/Il10tm1Roer involves: 129P2/OlaHsd	abnormal CD8-positive, alpha-beta T cell physiology	J:151551
	abnormal myeloid leukocyte morphology	J:151551
	decreased circulating interleukin-10 level	J:151551
	increased B cell number	J:151551
	increased CD4-positive, alpha-beta T cell number	J:151551
	increased plasma cell number	J:151551
Il10tm1.1Karp/Il10tm1.1Karp involves: C57BL/6	no abnormal phenotype detected	J:151551
Il10tm1.1Roer/Il10tm1.1Roer involves: 129P2/OlaHsd	abnormal myeloid leukocyte morphology	J:151551
	decreased circulating interleukin-10 level	J:151551
	increased B cell number	J:151551
	increased myeloid dendritic cell number	J:151551
	increased plasma cell number	J:151551
	increased susceptibility to endotoxin shock	J:151551
	increased T cell number	J:151551
	spleen hyperplasia	J:151551
Il10tm1.1Roer/Il10tm1.1Roer involves: 129P2/OlaHsd * C57BL/6	abnormal cytokine secretion	J:94537
	abnormal hypersensitivity reaction	J:94537
	abnormal innate immunity	J:94537
	increased susceptibility to bacterial infection	J:94537
	increased susceptibility to induced morbidity/mortality	J:94537
	intestinal inflammation	J:94537
Il10tm1Cgn/Il10tm1Cgn 129S.Cg-Il10tm1Cgn	decreased vasoconstriction	J:59742
Il10tm1Cgn/Il10tm1Cgn B6.129P2-Il10tm1Cgn	abnormal circulating interleukin-6 level	J:191723
	abnormal circulating interleukin-12b level	J:191723
Il10tm1Cgn/Il10tm1Cgn B6.129P2-Il10tm1Cgn/J	abnormal chemokine level	J:157787
	abnormal cytokine level	J:139972, J:157787
	abnormal neuron physiology	J:108086
	abnormal regulatory T cell physiology	J:125748
	abnormal sleep pattern	J:114404
	cecum inflammation	J:157787
	decreased mean systemic arterial blood pressure	J:146372
	decreased susceptibility to induced choroidal neovascularization	J:134144
	decreased vasoconstriction	J:59742
	impaired adaptive thermogenesis	J:114404
	impaired coordination	J:139972
	impaired exercise endurance	J:139972
	increased cerebral infarct size	J:108086
	increased circulating interferon-gamma level	J:157787
	increased circulating interleukin-1 alpha level	J:157787
	increased circulating interleukin-1 beta level	J:139972, J:157787
	increased circulating interleukin-2 level	J:157787
	increased circulating interleukin-6 level	J:139972, J:157787
	increased circulating interleukin-12 level	J:157787
	increased circulating interleukin-17 level	J:157787
	increased circulating tumor necrosis factor level	J:157787
	increased colon adenocarcinoma incidence	J:149347
	increased susceptibility to induced colitis	J:157787
	increased susceptibility to neuronal excitotoxicity	J:108086
	increased susceptibility to parasitic infection	J:157787
	increased vasoconstriction	J:146372
	large intestinal inflammation	J:149347
	rectal prolapse	J:149347
	slow postnatal weight gain	J:124308
Il10tm1Cgn/Il10tm1Cgn B10.129P2(B6)-Il10tm1Cgn/J	decreased length of allograft survival	J:44346
Il10tm1Cgn/Il10tm1Cgn involves: 129P2/OlaHsd	abnormal cytokine secretion	J:117122
	abnormal inflammatory response	J:117122
	abnormal reproductive system physiology	J:130208
	increased circulating interleukin-12 level	J:118833
	increased circulating tumor necrosis factor level	J:118833
	increased susceptibility to endotoxin shock	J:117122, J:118833
	intestinal inflammation	J:113376
	rectal prolapse	J:209365
Il10tm1Cgn/Il10tm1Cgn involves: 129P2/OlaHsd * 129S/SvEv	abnormal intestine physiology	J:59872
	colitis	J:59872
	decreased body weight	J:59872
Il10tm1Cgn/Il10tm1Cgn involves: 129P2/OlaHsd * C57BL/6	abnormal bone mineralization	J:93577
	abnormal bone structure	J:93577
	abnormal circulating enzyme level	J:110238
	abnormal circulating protein level	J:110238
	abnormal circulating serum albumin level	J:93577
	abnormal colon morphology	J:107077
	abnormal crypts of Lieberkuhn morphology	J:15222
	abnormal cytokine level	J:35020
	abnormal enterocyte morphology	J:15222
	abnormal glucose homeostasis	J:129479
	abnormal homeostasis	J:129479
	abnormal immune system physiology	J:35020
	abnormal interferon level	J:35020, J:107077, J:125760
	abnormal interleukin level	J:35020, J:51636, J:107077
	abnormal intestinal epithelium morphology	J:15222
	abnormal intestinal mucosa morphology	J:15222, J:68476
	abnormal iron level	J:15222
	abnormal Langerhans cell physiology	J:51636
	abnormal large intestine morphology	J:35020
	abnormal leukocyte morphology	J:35020
	abnormal level of surface class II molecules	J:15222
	abnormal lipid level	J:129479
	abnormal liver physiology	J:129479
	abnormal lymphocyte cell number	J:35020
	abnormal myelopoiesis	J:15222
	abnormal nitric oxide homeostasis	J:115459
	abnormal osteoblast differentiation	J:93577
	abnormal placental labyrinth vasculature morphology	J:113180
	abnormal protein level	J:129479
	abnormal response to infection	J:15222
	abnormal skeleton morphology	J:93577
	abnormal skeleton physiology	J:93577
	abnormal trabecular bone morphology	J:93577
	abnormal tumor necrosis factor level	J:51636, J:107077
	abnormal type IV hypersensitivity reaction	J:35510
	absent erythroid progenitor cell	J:15222
	alveolar process atrophy	J:147935
	anemia	J:15222
	cachexia	J:15222
	cecum inflammation	J:35020
	chronic inflammation	J:15222
	colitis	J:68476
	decreased airway responsiveness	J:62283, J:115459
	decreased bone mineral content	J:93577
	decreased bone strength	J:93577
	decreased bone trabecula number	J:93577
	decreased circulating cholesterol level	J:129479
	decreased circulating creatinine level	J:93577
	decreased circulating insulin level	J:129479
	decreased circulating iron level	J:15222
	decreased compact bone mass	J:93577
	decreased erythrocyte cell number	J:15222
	decreased hemoglobin content	J:15222
	decreased incidence of tumors by UV induction	J:125760
	decreased length of allograft survival	J:44346
	decreased physiological sensitivity to xenobiotic	J:115459
	decreased spleen iron level	J:15222
	decreased spleen red pulp amount	J:15222
	decreased T cell proliferation	J:125760
	decreased trabecular bone mass	J:93577
	decreased trabecular bone thickness	J:93577
	decreased tumor incidence	J:125760
	enhanced wound healing	J:117053
	hypochromic anemia	J:15222
normal immune system phenotype	J:15222, J:107077
increased CD4-positive, alpha-beta T cell number	J:35020
increased circulating cholesterol level	J:129479
increased fatty acids level	J:129479
increased granulocyte number	J:15222, J:35020
increased hepatocyte apoptosis	J:110238
increased IgE level	J:62283
increased IgG1 level	J:62283
increased IgG2a level	J:62283
increased insulin sensitivity	J:129479
increased interferon-gamma secretion	J:15222
increased intestinal adenocarcinoma incidence	J:68476
increased large intestine adenocarcinoma incidence	J:35020
increased leukotriene level	J:62283
increased liver triglyceride level	J:129479
increased myocardial infarct size	J:70292
increased placental labyrinth size	J:113180
increased susceptibility to parasitic infection	J:123927
increased susceptibility to type IV hypersensitivity reaction	J:51636
increased thermal nociceptive threshold	J:119039
increased thymus weight	J:107077
intestinal inflammation	J:15222, J:35020, J:107077
large intestinal inflammation	J:35020
microcytic anemia	J:15222
postnatal growth retardation	J:15222
premature death	J:15222
short femur	J:93577
small intestinal inflammation	J:35020
thymus hyperplasia	J:107077
Il10tm1Cgn/Il10tm1Cgn involves: 129P2/OlaHsd * C57BL/6 * DBA/1	colitis	J:84100
	decreased body weight	J:84100
Il10tm1Flv/Il10tm1Flv involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:116616
Il10tm1Hbo/Il10tm1Hbo involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	no abnormal phenotype detected	J:179239
Il10tm1Mhry/Il10tm1Mhry involves: 129P2/OlaHsd * C57BL/6	intestinal inflammation	J:117628
Il10tm1Roer/Il10tm1Roer involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:94537
Il10tm1Roer/Il10tm1Roer Foxp3tm4(YFP/icre)Ayr/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal regulatory T cell physiology	J:134513
	abnormal type IV hypersensitivity reaction	J:134513
	colitis	J:134513
	decreased interleukin-10 secretion	J:134513
	lung inflammation	J:134513
Il10tm1Roer/Il10tm1Roer Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	abnormal cytokine secretion	J:94537
	abnormal hypersensitivity reaction	J:94537
	abnormal intestinal mucosa morphology	J:94537
	abnormal lymph node morphology	J:94537
	crypts of Lieberkuhn abscesses	J:94537
	increased susceptibility to induced morbidity/mortality	J:94537
	increased susceptibility to parasitic infection	J:94537
	intestinal inflammation	J:94537
	intestinal ulcer	J:94537
	liver inflammation	J:94537
	peritoneal inflammation	J:94537
	rectal prolapse	J:94537
Il10tm2Hbo/Il10tm2Hbo involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	no abnormal phenotype detected	J:179239
Il10tm2Roer/Il10tm2Roer Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6	abnormal cytokine secretion	J:117122
	abnormal inflammatory response	J:117122
	increased susceptibility to endotoxin shock	J:117122
Il10tm2Roer/Il10tm2Roer Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal inflammatory response	J:117122
	increased susceptibility to endotoxin shock	J:117122
Tg(IL2-Il10)1Kro/0 involves: C3H * C57BL/6	abnormal cytokine secretion	J:41588
	decreased susceptibility to parasitic infection	J:41588
	increased susceptibility to bacterial infection	J:80569
Tg(INS-Il10)#Sar/0 involves: BALB/c	abnormal exocrine pancreas morphology	J:107927
	abnormal pancreas physiology	J:107927
	abnormal vascular endothelial cell morphology	J:107927
	pancreas inflammation	J:107927
	periinsulitis	J:107927