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Igf2
Gene Detail
Symbol

Name
ID
Igf2
insulin-like growth factor 2
MGI:96434
Synonyms
Igf-2, Igf-II, M6pr, Mpr, Peg2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
87.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr7:142650766-142666816 bp, - strand
From VEGA annotation of GRCm38

  16051 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: insulin-like growth factor 2
Gene Tree: Igf2

Human
homologs
Human Homolog IGF2, insulin-like growth factor 2
NCBI Gene ID 3481
neXtProt AC  NX_P01344
Human Synonyms  C11orf43, IGF-II, PP9974
Human Chr (Location)  11p15.5; chr11:2129117-2149603 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human IGF2
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(10)
 
Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal.
 
Interactions
Igf2 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process carbohydrate metabolic process, exocrine pancreas development, ...
Component extracellular region, extracellular space, ...
Function growth factor activity, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (175 records)
Data Summary: Results (1186)    Tissues (376)    Images (153)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 600
Northern blot 226
Western blot 2
RT-PCR 298
RNase protection 51
cDNA source data(379)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(467) Genomic(42) cDNA(392) Primer pair(32) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035324 (Evidence)
Ensembl Gene ModelENSMUSG00000048583 (Evidence)
Entrez Gene16002 (Evidence)
UniGene3862
DFCITC1573580, TC1584759, TC1603248, TC1605881
DoTSDT.101260838, DT.102555494, DT.110983695, DT.537515
NIA Mouse Gene IndexU029486
Consensus CDS ProjectCCDS22033.2, CCDS52458.1
International Mouse Knockout Project StatusIgf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035324 VEGA Gene Model | MGI Sequence Detail 16051 C57BL/6J ±  kb
transcript OTTMUST00000035618 VEGA | MGI Sequence Detail 4722 Not Applicable 
polypeptide OTTMUSP00000015966 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(10) UniProt(11)
Polymorphisms
All PCR and RFLP(6) : PCR(4) RFLP(2) SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
InterPro IPR022350 Insulin-like growth factor
InterPro IPR022334 Insulin-like growth factor II
InterPro IPR013576 Insulin-like growth factor II E-peptide, C-terminal
Protein Ontology PR:000008942 insulin-like growth factor II
References
(Earliest) J:8474 Stempien MM, et al., Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 1986 Oct;5(5):357-61
(Latest) J:210349 Mainigi MA, et al., Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod. 2014 Feb;90(2):26
All references(384)
Other
accession IDs
MGD-MRK-11227, MGD-MRK-11230, MGI:2142106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory