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Igf2 Gene Detail
Summary
  • Symbol
    Igf2
  • Name
    insulin-like growth factor 2
  • Synonyms
    Igf-2, Igf-II, M6pr, Mpr, Peg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96434
    NCBI Gene: 16002
  • Gene Overview
    MyGene.info: IGF2
Location & Maps
more
  • Sequence Map
    Chr7:142650766-142666816 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16051 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.99 cM
  • Mapping Data
    29 experiments
Homology
more
  • Human Ortholog
    IGF2, insulin like growth factor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IGF2, insulin like growth factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C11orf43, GRDF, IGF-II, PP9974
  • Links
    NCBI Gene ID: 3481
    neXtProt AC: NX_P01344

  • Chr Location
    11p15.5; chr11:2129112-2149603 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Igf2 mouse models; 4 with human IGF2 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent, 2   OMIM: 125852 View 3 models
       Beckwith-Wiedemann Syndrome; BWS   OMIM: 130650
Growth Restriction, Severe, with Distinctive Facies; GRDF   OMIM: 616489
Silver-Russell Syndrome; SRS   OMIM: 180860
Wilms Tumor 1; WT1   OMIM: 194070
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 8 alleles in 15 genetic backgrounds
    67 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    2
  • Targeted
    10
  • Transgenic
    8
Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035324 VEGA Gene Model | MGI Sequence Detail 16051 C57BL/6J ±  kb
transcript OTTMUST00000035618 VEGA | MGI Sequence Detail 4722 Not Applicable  
polypeptide OTTMUSP00000015966 VEGA | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    87 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 467
    Genomic 42
    cDNA 392
    Primer pair 32
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11227, MGD-MRK-11230, MGI:2142106
References
more
  • Summaries
    All 396
    Developmental Gene Expression 191
    Diseases 2
    Gene Ontology 10
    Phenotypes 89
  • Earliest
    J:8474 Stempien MM, et al., Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 1986 Oct;5(5):357-61
  • Latest
    J:235776 Terauchi A, et al., Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory