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Igf2
Gene Detail
Symbol

Name
ID
Igf2
insulin-like growth factor 2
MGI:96434
Synonyms
Igf-2, Igf-II, M6pr, Mpr, Peg2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
87.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr7:142650766-142666816 bp, - strand
From VEGA annotation of GRCm38

  16051 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: IGF2
Protein SuperFamily: insulin-like growth factor 2
Gene Tree: Igf2

Human
homologs
IGF2, insulin-like growth factor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3481
neXtProt AC: NX_P01344

Human Synonyms: C11orf43, IGF-II, PP9974

Human Chr (Location): 11p15.5; chr11:2129112-2149603 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human IGF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(2) Targeted(10) Transgenic(1)
 
Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal.
 
Human Diseases Modeled in Mice Using Igf2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Igf2 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process activation of protein kinase activity, carbohydrate metabolic process, ...
Component extracellular exosome, extracellular region, ...
Function growth factor activity, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (183 records)
Data Summary: Results (1186)    Tissues (376)    Images (153)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 600
Northern blot 226
Western blot 2
RT-PCR 298
RNase protection 51
cDNA source data(379)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase igf2 ; ZFIN igf2a, igf2b    NEW 
Molecular
reagents
All nucleic(467) Genomic(42) cDNA(392) Primer pair(32) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000035324 (Evidence)
Ensembl Gene Model ENSMUSG00000048583 (Evidence)
Entrez Gene 16002 (Evidence)
UniGene 3862
DFCI TC1573580, TC1584759, TC1603248, TC1605881
DoTS DT.101260838, DT.102555494, DT.110983695, DT.537515
NIA Mouse Gene Index U029486
Consensus CDS Project CCDS22033.2, CCDS52458.1
International Mouse Phenotyping Consortium Status Igf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035324 VEGA Gene Model | MGI Sequence Detail 16051 C57BL/6J ±  kb
transcript OTTMUST00000035618 VEGA | MGI Sequence Detail 4722 Not Applicable 
polypeptide OTTMUSP00000015966 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(8) UniProt(6)
Polymorphisms
All PCR and RFLP(6) : PCR(4) RFLP(2) SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
InterPro IPR022350 Insulin-like growth factor
InterPro IPR022334 Insulin-like growth factor II
InterPro IPR013576 Insulin-like growth factor II E-peptide, C-terminal
Protein Ontology PR:000008942 insulin-like growth factor II
References
(Earliest) J:8474 Stempien MM, et al., Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 1986 Oct;5(5):357-61
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(386)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11227, MGD-MRK-11230, MGI:2142106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory