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Igf2 Gene Detail
Summary
  • Symbol
    Igf2
  • Name
    insulin-like growth factor 2
  • Synonyms
    Igf-2, Igf-II, M6pr, Mpr, Peg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96434
    NCBI Gene: 16002
  • Alliance
  • Transcription Start Sites
    58 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142204503-142220553 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.99 cM
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96434
protein coding gene Chr7:142204503-142220566 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033261
protein coding gene Chr7:147915804-147934137 (-)
A/J MGP_AJ_G0033244
protein coding gene Chr7:143645892-143662035 (-)
AKR/J MGP_AKRJ_G0033176
protein coding gene Chr7:147675547-147691596 (-)
BALB/cJ MGP_BALBcJ_G0033245
protein coding gene Chr7:143417465-143433412 (-)
C3H/HeJ MGP_C3HHeJ_G0032960
protein coding gene Chr7:147436085-147454355 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033755
protein coding gene Chr7:153262361-153282637 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030728
protein coding gene Chr7:144854325-144870428 (-)
CAST/EiJ MGP_CASTEiJ_G0032283
protein coding gene Chr7:139752723-139775983 (-)
CBA/J MGP_CBAJ_G0032931
protein coding gene Chr7:158511697-158533256 (-)
DBA/2J MGP_DBA2J_G0033085
protein coding gene Chr7:141596956-141614026 (-)
FVB/NJ MGP_FVBNJ_G0033034
protein coding gene Chr7:141534396-141550882 (-)
LP/J MGP_LPJ_G0033178
protein coding gene Chr7:149426487-149442449 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033068
protein coding gene Chr7:159124753-159144024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033774
protein coding gene Chr7:146627176-146649889 (-)
PWK/PhJ MGP_PWKPhJ_G0031991
protein coding gene Chr7:134926171-134943011 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031837
protein coding gene Chr7:133425497-133441537 (-)
WSB/EiJ MGP_WSBEiJ_G0032395
protein coding gene Chr7:147621277-147639202 (-)



Homology
more
  • Human Ortholog
    IGF2, insulin like growth factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF2, insulin like growth factor 2
  • Synonyms
    C11orf43, GRDF, IGF-II, PP9974, SRS3
  • Links
    NCBI Gene ID: 3481
    neXtProt AC: NX_P01344
    UniProt: P01344

  • Chr Location
    11p15.5; chr11:2129112-2158391 (-)  GRCh38

Human Diseases
more
  • Diseases
    4 with human IGF2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 7 alleles in 13 genetic backgrounds
    81 phenotypes from multigenic genotypes
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048583 Ensembl Gene Model | MGI Sequence Detail 16051 C57BL/6J ±  kb
    transcript ENSMUST00000121128 Ensembl | MGI Sequence Detail 4722 Not Applicable  
    polypeptide ENSMUSP00000114076 Ensembl | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 510
      Genomic 42
      cDNA 395
      Primer pair 51
      Other 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11227, MGD-MRK-11230, MGI:2142106
    References
    more
    • Summaries
      All 568
      Developmental Gene Expression 251
      Diseases 2
      Gene Ontology 21
      Phenotypes 115
    • Earliest
      J:8474 Stempien MM, et al., Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 1986 Oct;5(5):357-61
    • Latest
      J:334804 Fertan E, et al., Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 in Alzheimer's disease. Sci Rep. 2023 Feb 4;13(1):2043

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory