Igf2
Gene Detail

Symbol Name ID

Igf2 insulin-like growth factor 2 MGI:96434

Synonyms

Igf-2, Igf-II, M6pr, Mpr, Peg2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

87.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr7:142650766-142666816 bp, - strand From VEGA annotation of GRCm38   16051 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: insulin-like growth factor 2
Gene Tree: Igf2

Human homologs

Human Homolog		IGF2, insulin-like growth factor 2 (somatomedin A)
NCBI Gene ID		3481
neXtProt AC		NX_P01344
Human Synonyms		C11orf43, IGF-II, PP9974
Human Chr (Location)		11p15.5; chr11:2150347-2170833 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IGF2

Alleles and phenotypes

All alleles(12) : Targeted(10) Gene trapped(2)
 

Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	carbohydrate metabolic process, exocrine pancreas development, ...
Component	extracellular region, extracellular space
Function	growth factor activity, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (165 records)
Data Summary: Results (1195)    Tissues (369)    Images (150)
Theiler Stages: 2, 3, 5, 6, 8, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	602
Northern blot	226
Western blot	2
RT-PCR	305
RNase protection	51

cDNA source data(369)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(457) Genomic(42) cDNA(382) Primer pair(32) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000035324 (Evidence)
Ensembl Gene Model	ENSMUSG00000048583 (Evidence)
Entrez Gene	16002 (Evidence)
UniGene	3862
DFCI	TC1573580, TC1584759, TC1603248, TC1605881
DoTS	DT.101260838, DT.102555494, DT.110983695, DT.537515
NIA Mouse Gene Index	U029486
Consensus CDS Project	CCDS22033.2, CCDS52458.1
International Mouse Knockout Project Status	Igf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035324	VEGA Gene Model | MGI Sequence Detail	16051	C57BL/6J
transcript	OTTMUST00000035618	VEGA | MGI Sequence Detail	4722	Not Applicable
polypeptide	OTTMUSP00000015966	VEGA | MGI Sequence Detail	191	Not Applicable

All sequences(81) RefSeq(6) UniProt(6)

Polymorphisms

All PCR and RFLP(6) : PCR(4) RFLP(2) SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022353	Insulin, conserved site
InterPro	IPR022352	Insulin family
InterPro	IPR016179	Insulin-like
InterPro	IPR022350	Insulin-like growth factor
InterPro	IPR022334	Insulin-like growth factor II
InterPro	IPR013576	Insulin-like growth factor II E-peptide, C-terminal
Protein Ontology	PR:000008942	insulin-like growth factor II

References

(Earliest) J:8474 Stempien MM, et al., Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 1986 Oct;5(5):357-61
(Latest) J:194471 Borensztein M, et al., Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse. Development. 2013 Mar;140(6):1231-9
All references(371)

Other accession IDs

MGD-MRK-11227, MGD-MRK-11230, MGI:2142106