Phenotypes Associated with This Genotype

Genotype
MGI:3818740

• Allelic Composition: Tg(Ins-Igf2)1Fbos/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:141527 )

• beta cell mass is increased 3-fold compared to in wild-type mice

pancreatic islet hyperplasia ( J:141527 )

• islet cells are larger, more elongated and more irregularly shared than in wild-type mice

disorganized pancreatic islets ( J:141527 )

• several core islet cells do not stain positive for insulin and glucagon-producing cells are scattered throughout the islet core unlike in wild-type mice

increased pancreas weight ( J:141527 )

• at 4 months of age, pancreatic weight is increased compared to in wild-type mice

abnormal pancreatic beta cell physiology ( J:141527 )

• when exposed to glucose, beta cells produce more insulin and exhibit increased glucose metabolism compared to in wild-type cells

increased insulin secretion ( J:141527 )

• at 4 months of age, beta cells secrete more insulin than wild-type cells when exposed to glucose

• insulin concentration in beta cells is 70% higher than in wild-type cells while pro-insulin levels are 6-fold higher than in wild-type cells

• when fed a high fat diet, mice exhibit increased compared to in similarly treated wild-type mice

homeostasis/metabolism

increased insulin secretion ( J:141527 )

• at 4 months of age, beta cells secrete more insulin than wild-type cells when exposed to glucose

• insulin concentration in beta cells is 70% higher than in wild-type cells while pro-insulin levels are 6-fold higher than in wild-type cells

• when fed a high fat diet, mice exhibit increased compared to in similarly treated wild-type mice

increased circulating glucose level ( J:141527 )

• at 3 months of age

hyperglycemia ( J:141527 )

• when fed a high fat diet, 30% of mice develop severe hyperglycemia and the remaining mice develop mild hyperglycemia compared to similarly treated wild-type mice

increased circulating insulin level ( J:141527 )

• at 1 month of age, insulin plasma levels are 3-fold higher than in wild-type mice

increased circulating free fatty acids level ( J:141527 )

• slight

increased circulating triglyceride level ( J:141527 )

• slight

insulin resistance ( J:141527 )

• at 4 months of age, mice exhibit insulin resistance

• Background Sensitivity: mice exhibit insulin resistance that is less severe than on a C57BL/6 C57BL/6Ks SJL mixed background

growth/size/body

increased pancreas weight ( J:141527 )

• at 4 months of age, pancreatic weight is increased compared to in wild-type mice

decreased susceptibility to weight gain ( J:141527 )

• when fed a high fat diet, 30% of mice lose 25% of their body weight unlike wild-type mice

• however, most mice exhibit a similar weight gain as observed in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus 2		DOID:0110741	OMIM:125852	J:141527