Rr27 Other Genome Feature Detail

Summary

• Symbol
  Rr27
• Name
  regulatory region 27
• Synonyms
  DMD, IC1, ICR

• Feature Type
  imprinting control region
• IDs
  MGI:5489785

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• J:238342 fig1A: based on distances from SacI (chr7:142136563) and HindIII (142133985) restriction sites: chr7:142133885-142136283 (GRCm39) (~2.4 kb)

• Genetic Map
  Chromosome 7, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  26 phenotypes from 18 alleles in 12 genetic backgrounds
  3 phenotypes from multigenic genotypes
  40 phenotype references
  

• All Mutations and Alleles
  26
• Targeted
  26
• Find Mice (IMSR)
  6 strains or lines available

Mice homozygous for one allele disrupting this imprinting control region (or differentially methylated region) between H19 and Igf2 exhibit normal methylation imprinting. An allele replacing it with the chicken beta globin chromatin insulator results in the lack of Igf2 activation and H19 suppression when paternally inherited, leading to smaller mice. Endocrine junctional zone (Jz)-specific KO leads to sex-specific changes in placental endocrine capacity.

References

• Summaries
  All 42

  Phenotypes 40
• Earliest
  J:52162 Thorvaldsen JL, et al., Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev. 1998 Dec 1;12(23):3693-702
• Latest
  J:342873 Liao J, et al., Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region. Sci Adv. 2023 Sep 8;9(36):eadi2050