Slc6a4
Gene Detail

Symbol Name ID

Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 MGI:96285

Synonyms

5-HTT, Htt, Sert

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:76998603-77032340 bp, + strand From VEGA annotation of GRCm38   33738 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc6a4

Human homologs

Human Homolog		SLC6A4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
NCBI Gene ID		6532
neXtProt AC		NX_P31645
Human Synonyms		5HTT, 5-HTT, 5-HTTLPR, hSERT, HTT, OCD1, SERT, SERT1
Human Chr (Location)		17q11.2; chr17:28523376-28562954 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SLC6A4

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(3)
 

Homozygotes for a targeted null mutation exhibit greatly diminished brain serotonin levels and lack cortical barrel patterns. Also, mutants lack the locomotor enhancing response to the drug (+)-3,4-methylenedioxymethamphetamine.

 
Human Diseases Modeled Using Mouse Slc6a4 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	brain morphogenesis, cellular response to cGMP, ...
Component	cytosol, endomembrane system, ...
Function	actin filament binding, cocaine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (44 records)
Data Summary: Results (184)    Tissues (143)    Images (40)
Theiler Stages: 2, 3, 4, 12, 14, 16, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	171
In situ reporter (knock in)	4
RT-PCR	9

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(2) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006240 (Evidence)
Ensembl Gene Model	ENSMUSG00000020838 (Evidence)
Entrez Gene	15567 (Evidence)
UniGene	300318
DFCI	TC1581807, TC1592878, TC1676318
DoTS	DT.526527, DT.94136795
NIA Mouse Gene Index	U012972
Consensus CDS Project	CCDS25074.1
International Mouse Knockout Project Status	Slc6a4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006240	VEGA Gene Model | MGI Sequence Detail	33738	C57BL/6J
transcript	OTTMUST00000014091	VEGA | MGI Sequence Detail	2796	Not Applicable
polypeptide	OTTMUSP00000006550	VEGA | MGI Sequence Detail	630	Not Applicable

All sequences(49) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR013086	Sodium:neurotransmitter symporter, serotonin, N-terminal
Protein Ontology	PR:000015189	sodium-dependent serotonin transporter

References

(Earliest) J:11901 Gregor P, et al., Murine serotonin transporter: sequence and localization to chromosome 11. Mamm Genome. 1993;4(5):283-4
(Latest) J:192363 Olexova L, et al., Animal models of autism with a particular focus on the neural basis of changes in social behaviour: an update article. Neurosci Res. 2012 Dec;74(3-4):184-94
All references(207)

Other accession IDs

MGD-MRK-11013, MGI:2144118