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Slc6a4
Gene Detail
 Symbol
Name
ID
Slc6a4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
MGI:96285
Synonyms 5-HTT, Htt, Sert
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:76998603-77032340 bp, + strand
From VEGA annotation of GRCm38

  33738 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc6a4

Human
homologs
Human Homolog SLC6A4, solute carrier family 6 (neurotransmitter transporter), member 4
NCBI Gene ID 6532
neXtProt AC  NX_P31645
Human Synonyms  5HTT, 5-HTT, 5-HTTLPR, hSERT, HTT, OCD1, SERT, SERT1
Human Chr (Location)  17q11.2; chr17:30194319-30235968 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC6A4
Alleles
and
phenotypes
All alleles(13) : Gene trapped(3) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit greatly diminished brain serotonin levels and lack cortical barrel patterns. Also, mutants lack the locomotor enhancing response to the drug (+)-3,4-methylenedioxymethamphetamine.
 
Human Diseases Modeled Using Mouse Slc6a4 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process brain morphogenesis, cellular response to cGMP, ...
Component cytosol, endomembrane system, ...
Function actin filament binding, cocaine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (236)    Tissues (195)    Images (42)
Theiler Stages: 2, 3, 4, 12, 14, 16, 19, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 220
In situ reporter (knock in) 4
RT-PCR 12
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006240 (Evidence)
Ensembl Gene ModelENSMUSG00000020838 (Evidence)
Entrez Gene15567 (Evidence)
UniGene300318
DFCITC1581807, TC1592878, TC1676318
DoTSDT.526527, DT.94136795
NIA Mouse Gene IndexU012972
Consensus CDS ProjectCCDS25074.1
International Mouse Knockout Project StatusSlc6a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006240 VEGA Gene Model | MGI Sequence Detail 33738 C57BL/6J ±  kb
transcript OTTMUST00000014091 VEGA | MGI Sequence Detail 2796 Not Applicable 
polypeptide OTTMUSP00000006550 VEGA | MGI Sequence Detail 630 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(10) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(256 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR013086 Sodium:neurotransmitter symporter, serotonin, N-terminal
Protein Ontology PR:000015189 sodium-dependent serotonin transporter
References (Earliest) J:11901 Gregor P, et al., Murine serotonin transporter: sequence and localization to chromosome 11. Mamm Genome. 1993;4(5):283-4
(Latest) J:210608 Goodfellow NM, et al., Mice with compromised 5-HTT function lack phosphotyrosine-mediated inhibitory control over prefrontal 5-HT responses. J Neurosci. 2014 Apr 23;34(17):6107-11
All references(226)
Other
accession IDs
MGD-MRK-11013, MGI:2144118

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory