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Slc6a4
Gene Detail
Symbol

Name
ID
Slc6a4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
MGI:96285
Synonyms
5-HTT, Htt, Sert
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:76998603-77032340 bp, + strand
From VEGA annotation of GRCm38

  33738 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC6A4
Gene Tree: Slc6a4

Human
homologs
SLC6A4, solute carrier family 6 (neurotransmitter transporter), member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6532
neXtProt AC: NX_P31645

Human Synonyms: 5HTT, 5-HTT, 5-HTTLPR, hSERT, HTT, OCD1, SERT, SERT1

Human Chr (Location): 17q11.2; chr17:30194319-30235968 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLC6A4

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(3) Targeted(11) Transgenic(1)
Genomic Mutations involving Slc6a4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit greatly diminished brain serotonin levels and lack cortical barrel patterns. Also, mutants lack the locomotor enhancing response to the drug (+)-3,4-methylenedioxymethamphetamine.
 
Human Diseases Modeled in Mice Using Slc6a4 (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Slc6a4 interacts with 117 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process ammonium transmembrane transport, brain morphogenesis, ...
Component cytosol, endomembrane system, ...
Function actin filament binding, cocaine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (233)    Tissues (192)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 220
In situ reporter (knock in) 4
RT-PCR 9
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN slc6a4a, slc6a4b    NEW 
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(19) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006240 (Evidence)
Ensembl Gene Model ENSMUSG00000020838 (Evidence)
Entrez Gene 15567 (Evidence)
UniGene 300318
DFCI TC1581807, TC1592878, TC1676318
DoTS DT.526527, DT.94136795
NIA Mouse Gene Index U012972
Consensus CDS Project CCDS25074.1
International Mouse Phenotyping Consortium Status Slc6a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006240 VEGA Gene Model | MGI Sequence Detail 33738 C57BL/6J ±  kb
transcript OTTMUST00000014091 VEGA | MGI Sequence Detail 2796 Not Applicable 
polypeptide OTTMUSP00000006550 VEGA | MGI Sequence Detail 630 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(256 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR013086 Sodium:neurotransmitter symporter, serotonin, N-terminal
Protein Ontology PR:000015189 sodium-dependent serotonin transporter
References
(Earliest) J:11901 Gregor P, et al., Murine serotonin transporter: sequence and localization to chromosome 11. Mamm Genome. 1993;4(5):283-4
(Latest) J:221001 Kloke V, et al., Hope for the best or prepare for the worst? Towards a spatial cognitive bias test for mice. PLoS One. 2014;9(8):e105431
All references(233)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11013, MGI:2144118

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory