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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc6a4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
MGI:96285
30 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Htr1atm3.1Rhn/Htr1atm3.1Rhn
Slc6a4tm1(tTA)Cogr/Slc6a4+
involves: 129S1/Sv * BALB/cJ * C57BL/6 * CBA 		abnormal autonomic nervous system physiology J:137439
abnormal neuron physiology J:137439
decreased body temperature J:137439
decreased heart rate J:137439
decreased survivor rate J:137439
premature death J:137439
Htr1btm1Rhn/Htr1btm1Rhn
Slc6a4tm1Kpl/Slc6a4tm1Kpl
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal heart valve morphology J:121505
cardiac fibrosis J:121505
decreased cardiac muscle contractility J:121505
dilated cardiomyopathy J:121505
heart valve hyperplasia J:121505
Htr2atm1Grch/Htr2atm2Grch
Slc6a4tm1(cre)Grch/Slc6a4+
involves: 129S6/SvEvTac 		abnormal anxiety-related response J:110958
Ptentm1Rps/Pten+
Slc6a4tm1Kpl/Slc6a4+
B6.129-Slc6a4tm1Kpl Ptentm1Rps 		abnormal social investigation J:144937
decreased prepulse inhibition J:144937
increased brain weight J:144937
megacephaly J:144937
reduced sensorimotor gating J:144937
Slc6a3tm1Mca/Slc6a3tm1Mca
Slc6a4tm1Kpl/Slc6a4+
involves: 129P2/OlaHsd * C57BL/6J 		impaired conditioned place preference behavior J:93114
Slc6a3tm1Mca/Slc6a3tm1Mca
Slc6a4tm1Kpl/Slc6a4tm1Kpl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal adenohypophysis morphology J:93114
impaired conditioned place preference behavior J:93114
increased exploration in new environment J:93114
postnatal growth retardation J:93114
small pituitary gland J:93114
Slc6a4tm1(SLC6A4)Kres/Slc6a4tm1(SLC6A4)Kres
involves: C57BL/6 		no abnormal phenotype detected J:101977
Slc6a4tm2(SLC6A4)Kres/Slc6a4tm2(SLC6A4)Kres
involves: C57BL/6 		no abnormal phenotype detected J:101977
Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir
Slc6a4tm1(cre)Xz/Slc6a4+
involves: 129S1/Sv * C57BL/6J 		abnormal catecholamine level J:197966
abnormal emotion/affect behavior J:197966
decreased anxiety-related response J:197966
decreased locomotor activity J:197966
decreased serotonin level J:197966
normal nervous system phenotype J:197966
postnatal lethality, incomplete penetrance J:197966
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory