Phenotypes Associated with This Genotype

Genotype
MGI:4417856

• Allelic Composition: Slc6a4^tm1(cre)Xz/Slc6a4^tm1(cre)Xz
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:155633 )

• 75% of mice die with the first week after birth

cardiovascular system

cardiac fibrosis ( J:155633 )

• at E18.5, mice exhibit an increase in collagen accumulation in the myocardium and valvular and perivascular regions of the heart unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sudden infant death syndrome		DOID:9007	OMIM:272120	J:155633