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Phenotypes Associated with This Genotype
Genotype
MGI:3640114
Allelic
Composition
Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic
Background
B6.129-Slc6a4tm1Kpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4tm1Kpl mutation (3 available); any Slc6a4 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• traveled a significantly shorter distance in the open field
• spent significantly less time in the center of the open field
• showed exaggerated immobility in response to repeated, but not acute, exposure to the tail suspension test
• buried significantly fewer marbles than control
• male mutant mice spend more time in an empty cage than in a cage with a strange mouse in the sociability choice test; female mutant mice did not behave differently than controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:192363


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory