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Gstp1
Gene Detail
Symbol

Name
ID
Gstp1
glutathione S-transferase, pi 1
MGI:95865
Synonyms
Gst p-1, GstpiB
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:4035407-4037921 bp, - strand
From VEGA annotation of GRCm38

  2515 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:660  Vertebrate Homology Class
1 human; 3 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 3 western clawed frog; 2 zebrafish

HCOP human homology predictions: GSTP1
Gene Tree: Gstp1

Human
homologs
GSTP1, glutathione S-transferase pi 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2950
neXtProt AC: NX_P09211

Human Synonyms: DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI

Human Chr (Location): 11q13; chr11:67583595-67586653 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
 
Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.
 
Interactions
Gstp1 interacts with 7 markers (Mir204, Mir293, Mir429, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cellular response to lipopolysaccharide, common myeloid progenitor cell proliferation, ...
Component cytoplasm, cytosol, ...
Function dinitrosyl-iron complex binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (124)    Tissues (124)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 123
cDNA source data(415)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gstp1    NEW 
Molecular
reagents
All nucleic(419) Genomic(4) cDNA(415)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000046062 (Evidence)
Ensembl Gene Model ENSMUSG00000060803 (Evidence)
Entrez Gene 14870 (Evidence)
UniGene 299292
DoTS DT.60118184
EC 2.5.1.18
PDB 1BAY, 1GLP, 1GLQ, 1GSY, 1GTI, 2GLR, 2OA7, 2OAC, 2OAD, 3O76
Consensus CDS Project CCDS29411.1
International Mouse Phenotyping Consortium Status Gstp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046062 VEGA Gene Model | MGI Sequence Detail 2515 C57BL/6J ±  kb
transcript OTTMUST00000120279 VEGA | MGI Sequence Detail 757 Not Applicable 
polypeptide OTTMUSP00000066649 VEGA | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(91 from dbSNP Build 137)    SNPs within 2kb including multiple locations(135)
Protein-related
information
ResourceIDDescription
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR003082 Glutathione S-transferase, Pi class
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000035159 glutathione S-transferase P 1
References
(Earliest) J:48429 Hatayama I, et al., A cDNA sequence coding a class pi glutathione S-transferase of mouse. Nucleic Acids Res. 1990 Aug 11;18(15):4606
(Latest) J:222516 Zhang J, et al., Glutathione S-transferase P influences redox and migration pathways in bone marrow. PLoS One. 2014;9(9):e107478
All references(68)
Other
accession IDs
MGD-MRK-10324

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory