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Gstp1
Gene Detail
 Symbol
Name
ID
Gstp1
glutathione S-transferase, pi 1
MGI:95865
Synonyms Gst p-1, GstpiB
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:4035411-4037912 bp, - strand
From NCBI annotation of GRCm38

  2502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:660  Vertebrate Homology Class
1 human; 3 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 2 zebrafish

Gene Tree: Gstp1

Human
homologs
Human Homolog GSTP1, glutathione S-transferase pi 1
NCBI Gene ID 2950
neXtProt AC  NX_P09211
Human Synonyms  DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
Human Chr (Location)  11q13; chr11:67583595-67586653 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(3) Targeted(2)
 
Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.
 
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cellular response to lipopolysaccharide, common myeloid progenitor cell proliferation, ...
Component cytoplasm, cytosol, ...
Function dinitrosyl-iron complex binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (124)    Tissues (124)    Images (18)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 123
cDNA source data(415)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(419) Genomic(4) cDNA(415)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000060803 (Evidence)
Entrez Gene14870 (Evidence)
UniGene299292
DoTSDT.60118184
EC2.5.1.18
PDB1BAY, 1GLP, 1GLQ, 1GSY, 1GTI, 2GLR, 2OAC, 2OAD, 2OA7, 3O76
Consensus CDS ProjectCCDS29411.1
International Mouse Knockout Project StatusGstp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14870 NCBI Gene Model | MGI Sequence Detail 2502 C57BL/6J ±  kb
transcript NM_013541 RefSeq | MGI Sequence Detail 744 C57BL/6 
polypeptide P19157 UniProt | EBI | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(91 from dbSNP Build 137)    SNPs within 2kb including multiple locations(135)
Protein-related
information
ResourceIDDescription
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR003082 Glutathione S-transferase, Pi class
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000035159 glutathione S-transferase P 1
Graphical View of Protein Domain Structure
References (Earliest) J:48429 Hatayama I, et al., A cDNA sequence coding a class pi glutathione S-transferase of mouse. Nucleic Acids Res. 1990 Aug 11;18(15):4606
(Latest) J:191045 Huebner AJ, et al., Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell. 2012 Dec 11;23(6):1238-46
All references(65)
Other
accession IDs
MGD-MRK-10324

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory