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Gstp1 Gene Detail
Summary
  • Symbol
    Gstp1
  • Name
    glutathione S-transferase, pi 1
  • Synonyms
    Gst p-1, GstpiB
  • Feature Type
    protein coding gene
  • IDs
    MGI:95865
    NCBI Gene: 14870
  • Gene Overview
    MyGene.info: GSTP1
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 19, 3.75 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
  • Vertebrate Orthologs
    15
  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
  • Links
    NCBI Gene ID: 2950
    neXtProt AC: NX_P09211
    UniProt: P09211

  • Chr Location
    11q13.2; chr11:67583595-67586653 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 660
    1 human;3 mouse;1 rat;1 chimpanzee;1 cattle;2 dog;2 zebrafish;3 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GSTP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000046062 VEGA Gene Model | MGI Sequence Detail 2515 C57BL/6J ±  kb
    transcript OTTMUST00000120279 VEGA | MGI Sequence Detail 757 Not Applicable  
    polypeptide OTTMUSP00000066649 VEGA | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      55 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 419
      Genomic 4
      cDNA 415

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10324
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 16
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:48429 Hatayama I, et al., A cDNA sequence coding a class pi glutathione S-transferase of mouse. Nucleic Acids Res. 1990 Aug 11;18(15):4606
    • Latest
      J:233693 Carvalho AN, et al., S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett. 2016 May;590(10):1455-66

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory